Techniques in the prevention and management of breast seroma: An evaluation of current practice

Gardner, Antony; Pass, Helen A.; Prance, Sarah

doi:10.1080/14733400500216814

Cited by 10 publications

(12 citation statements)

References 41 publications

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“…The fluid collection has traditionally been attributed to drainage of lymph from divided mammary and axillary lymphatics (1,8,9). However, recent studies have shown that seroma fluid composition is different from lymph, but is similar to inflammatory exudate (6).…”

Section: Discussionmentioning

confidence: 99%

“…Delay in the wound healing process following mastectomy and axillary dissection occuring due to the failure of flaps to adhere to the axilla and anterior chest wall after the operation is the most frequently accepted among these (9). In other words, it can be defined as inability of the wound edges to join together.…”

Section: Discussionmentioning

confidence: 99%

“…In other words, it can be defined as inability of the wound edges to join together. To achieve this closure, bovine thrombin, fibrin glue, talc, tranexamic acid, Corynebacterium parvum, tetracycline and several antineoplastic agents have been used, but all these approaches have failed to provide a significant effect (7,9). In 1913, Halsted described fixation of the skin flaps to the chest wall using sutures and found that this approach reduced seroma formation (22).…”

Section: Discussionmentioning

confidence: 99%

“…It has traditionally been assumed that drainage of lymph from divided mammary and axillary lymphatics secondary to mastectomy is responsible for seroma formation (1,8,9). More recent studies have pointed out loculation of the inflammatory exudate due to prolonged wound healing (1,6,8,10).…”

Section: Introductionmentioning

confidence: 99%

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Microporous Polysaccharide Hemospheres and Seroma Formation After Mastectomy and Axillary Dissection in Rats

et al. 2012

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Objective: Seroma is the most common complication after breast surgery. Several methods have been proposed to prevent seroma, but none of these provided a significant effect. A prolonged wound healing process is the most important cause of seroma. Microporous polysaccharide hemospheres (MPH) are used to achieve hemostasis. They may also accelerate wound healing. In this study, the effects of MPH on seroma formation were investigated.Material and Methods: Female Wistar rats weighing between 200 g and 250 g were used. There were eight rats in each of the control and study groups. Right breast mastectomy and axillary dissection were performed in all rats. While no application was performed after the operation in the control group, MPH was locally applied to the surgical site in the study group. Ten days after the operation, seroma fluid was aspirated and the total volume was recorded. The aspirates were analyzed and tissue samples were obtained from the surgical site.Results: Seroma was significantly lower in the study group (p=0.001). The mean albumin and lactate dehydrogenase levels were significantly lower in the study group (p=0.003). Pathological examination revealed that increase in fibrous tissue was significantly greater in the control group (p=0.032).Conclusion: MPH may reduce seroma after mastectomy.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Microporous Polysaccharide Hemospheres and Seroma Formation After Mastectomy and Axillary Dissection in Rats

et al. 2012

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“…Different causes of seroma have been proposed, such as the disruption of lymphatic drainage with fibrinolysis, or the surgical technique, especially the use of electrocautery versus knife dissection [2,3]. Several interventions have been attempted, including the use of tranexamic acid, bovine thrombin application, fibrin glue, avoiding drainage, postoperative arm activity and altering the surgical technique [4]. The origin of seroma remains unclear and no generally accepted preventive or curative method exists [1].…”

Section: Introductionmentioning

confidence: 99%

Seroma Production After Breast Cancer Surgery has a Pro-Inflammatory Component

Szecsi¹

2012

TOBCANJ

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Seroma formation is the most prevalent postoperative sequela after breast cancer surgery. A total of 263 aspirations of seroma fluid in 42 patients were performed after mastectomy; cytokines were measured in 148 cases. The concentration of interleukin-1 (IL-1), interleukin-6 (IL-6), interleukin-8 (IL-8), interleukin-10 (IL-10), interleukin-12p70 (IL-12) and tumor necrosis factor (TNF) were measured. The patients underwent 9.0 seroma aspirations on average (range 1-17) during an average of 30.7 days (range 7-72). The average cumulative seroma volume was 2056.1 mL (range 50-5130). In all samples, the maximal average concentrations of IL-6 (mean 10717 pg/mL, range 136-100000) and IL-8 (mean 7221 pg/mL, range 102-79828) were 55-200-fold above the serum/plasma levels of asymptomatic adults. In contrast, we observed levels similar to normal serum/plasma levels for IL-1 (mean 62.8 pg/mL, range 0-1226), IL-10 (mean 29.8 pg/mL, range 3.6-359), and lower-than-normal serum/plasma levels of TNF (mean 3.4 pg/mL, range 0-31.7) and IL-12 (mean 0.5 pg/mL, range 0-11.8). Patients with clinical infection had generally significant higher maximal IL-6 (p = 0.004) and IL-8 (0.019) than patients without clinical infection. However, most patients had no bacterial infection. None of the cytokines were associated with cumulative seroma volume, duration of seroma production or number of seroma aspirations. Seroma formation after mastectomy has a pro-inflammatory component, as indicated by the high levels of interleukin-6 and interleukin-8. However, these levels do not predict the course of seroma production.

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A prospective study on delayed shoulder exercises in reducing seroma formation after modified radical mastectomy

Ryntathiang

2015

Hellenic J Surg

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Techniques in the prevention and management of breast seroma: An evaluation of current practice

Cited by 10 publications

References 41 publications

Microporous Polysaccharide Hemospheres and Seroma Formation After Mastectomy and Axillary Dissection in Rats

Microporous Polysaccharide Hemospheres and Seroma Formation After Mastectomy and Axillary Dissection in Rats

Seroma Production After Breast Cancer Surgery has a Pro-Inflammatory Component

A prospective study on delayed shoulder exercises in reducing seroma formation after modified radical mastectomy

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