Techniques for assessment of wear between human cartilage surfaces

Verberne, Gabi; Merkher, Yulia; Halperin, G.; Maroudas, Alice; Etsion, I.

doi:10.1016/j.wear.2009.03.042

Cited by 25 publications

(12 citation statements)

References 21 publications

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“…To investigate wear features and conditions in synovial joints for OA understanding and assessment, various engineering configurations including wear simulators have been established to simulate real tribological environment and generate desired degrees of wear conditions [45][46][47]. The wear simulator which has been designed and constructed at the Mechanical Engineering workshop, James Cook University (JCU), Australia, was used to perform wear testing on sheep knee joints.…”

Section: Wear Testmentioning

confidence: 99%

A new approach to numerical characterisation of wear particle surfaces in three-dimensions for wear study

Tian

Wang

Peng

et al. 2012

Wear

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In the wear and tear process of synovial joints, wear particles generated and released from articular cartilage within the joints have different surface topology and mechanical property. Three-dimensional (3D) particle images acquired using laser scanning confocal microscopy (LSCM) contain appropriate surface information for quantitatively characterizing the surface topology and changes to seek a further understanding of the wear process and wear features. This paper presents a new attempt on the 3D numerical characterisation of wear particle surfaces using the field and feature parameter sets which are defined in ISO/FDIS 25178-2. Based on the innovative pattern recognition capability, the feature parameters are, for the first time, employed for quantitative analysis of wear debris surface textures. Through performing parameter classification, ANOVA analysis and correlation analysis, typical changing trends of the surface transformation of the wear particles along with the severity of wear conditions and Osteoarthritis (OA) have been observed. Moreover, the feature parameters have shown a significant sensitivity with the wear particle surfaces texture evolution under OA development. A correlation analysis of the numerical analysis results of cartilage surface texture variations and that of their wear particles has been conducted in this study. Key surface descriptors have been determined. Further research is needed to verify the above outcomes using clinic samples.

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Section: Wear Testmentioning

confidence: 99%

A new approach to numerical characterisation of wear particle surfaces in three-dimensions for wear study

Tian

Wang

Peng

et al. 2012

Wear

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“…The few studies that do utilize a cartilage-on-cartilage interface do so for studies of friction and/or lubrication[27,28], for comparison against chondroplasty materials[29,30], or for supraphysiological impaction[16]. Third, a final biological concern with many studies is the limited understanding of living cartilage response to tribological stresses as frozen or dead tissue has been typically used[21,31]. Eliminating the biological response from the system provides an incomplete picture of cartilage degradation.…”

Section: Introductionmentioning

confidence: 99%

“…Eliminating the biological response from the system provides an incomplete picture of cartilage degradation. Studies may have replicated one or two of the three aspects listed above, such as through the use of dead cartilage-on-cartilage in a pin-on-pin configuration[31] or living tissue with complex compression and shear loading to evaluate gene response[12,32]. However, according to our literature review, no current study has replicated all three aspects together.…”

Section: Introductionmentioning

confidence: 99%

Establishing a live cartilage-on-cartilage interface for tribological testing

et al. 2017

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Mechano-biochemical wear encompasses the tribological interplay between biological and mechanical mechanisms responsible for cartilage wear and degradation. The aim of this study was to develop and start validating a novel tribological testing system, which better resembles the natural joint environment through incorporating a live cartilage-on-cartilage articulating interface, joint specific kinematics, and the application of controlled mechanical stimuli for the measurement of biological responses in order to study the mechano-biochemical wear of cartilage. The study entailed two parts. In Part 1, the novel testing rig was used to compare two bearing systems: (a) cartilage articulating against cartilage (CoC) and (b) metal articulating against cartilage (MoC). The clinically relevant MoC, which is also a common tribological interface for evaluating cartilage wear, should produce more wear to agree with clinical observations. In Part II, the novel testing system was used to determine how wear is affected by tissue viability in live and dead CoC articulations. For both parts, bovine cartilage explants were harvested and tribologically tested for three consecutive days. Wear was defined as release of glycosaminoglycans into the media and as evaluation of the tissue structure. For Part I, we found that the live CoC articulation did not cause damage to the cartilage, to the extent of being comparable to the free swelling controls, whereas the MoC articulation caused decreased cell viability, extracellular matrix disruption, and increased wear when compared to CoC, and consistent with clinical data. These results provided confidence that this novel testing system will be adequate to screen new biomaterials for articulation against cartilage, such as in hemiarthroplasty. For Part II, the live and dead cartilage articulation yielded similar wear as determined by the release of proteoglycans and aggrecan fragments, suggesting that keeping the cartilage alive may not be essential for short term wear tests. However, the biosynthesis of glycosaminoglycans was significantly higher due to live CoC articulation than due to the corresponding live free swelling controls, indicating that articulation stimulated cell activity. Moving forward, the cell response to mechanical stimuli and the underlying mechano-biochemical wear mechanisms need to be further studied for a complete picture of tissue degradation.

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“…Qualitative observations of cartilage wear debris have been made [8–15]; however, quantitative measurements of cartilage wear have proven to be more challenging, with only a few studies having reported such measurements. The primary quantitative approaches proposed to date include biochemical assaying of cartilage and test solutions [16–20], characterization of changing articular layer thickness [17, 21–23], and changes in surface roughness [7, 20, 24–28]. One study examining polyethylene wear debris in hip arthroplasty reported the use of an automated particle analyzer [29].…”

Section: Introductionmentioning

confidence: 99%

Articular Cartilage Wear Characterization With a Particle Sizing and Counting Analyzer

Oungoulian¹,

Chang

Bortz

et al. 2013

Journal of Biomechanical Engineering

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Quantitative measurements of cartilage wear have been challenging, with no method having yet emerged as a standard. This study tested the hypothesis that latest-generation particle analyzers are capable of detecting cartilage wear debris generated during in vitro loading experiments that last 24 h or less, by producing measurable content significantly above background noise levels otherwise undetectable through standard biochemical assays. Immature bovine cartilage disks (4 mm diameter, 1.3 mm thick) were tested against glass using reciprocal sliding under unconfined compression creep for 24 h. Control groups were used to assess various sources of contamination. Results demonstrated that cartilage samples subjected to frictional loading produced particulate volume significantly higher than background noise and contamination levels at all tested time points (1, 2, 6, and 24 h, p<0.042). The particle counter was able to detect very small levels of wear (less than 0.02 percent of the tissue sample by volume), whereas no significant differences were observed in biochemical assays for collagen or glycosaminoglycans among any of the groups or time points. These findings confirm that latest-generation particle analyzers are capable of detecting very low wear levels in cartilage experiments conducted over a period no greater than 24 h.

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Techniques for assessment of wear between human cartilage surfaces

Cited by 25 publications

References 21 publications

A new approach to numerical characterisation of wear particle surfaces in three-dimensions for wear study

A new approach to numerical characterisation of wear particle surfaces in three-dimensions for wear study

Establishing a live cartilage-on-cartilage interface for tribological testing

Articular Cartilage Wear Characterization With a Particle Sizing and Counting Analyzer

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