Techniques for Assessment of Wear Between Human Cartilage Surfaces

Verberne, Gabi; Merkher, Yulia; Halperin, G.; Maroudas, Alice; Etsion, I.

doi:10.1115/esda2008-59146

Cited by 6 publications

(10 citation statements)

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“…These results agree with the mass of GAG released into the lubricant solutions during testing. More GAG is lost from the cartilage samples tested in saline (121.1 ± 33.1 μg (mean ± SD; consistent with literature reports 39, 40 ) than from those tested in 2.8M TEG (<3 μg). Hence, use of the 2.8M TEG biolubricant minimizes cartilage surface wear.…”

Section: Discussionsupporting

confidence: 89%

A Synthetic Bottle-Brush Polyelectrolyte Reduces Friction and Wear of Intact and Previously Worn Cartilage

Lakin

Cooper

Zakaria

et al. 2019

ACS Biomater. Sci. Eng.

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A poly(7-oxanorbornene-2-carboxylate) polymer containing pendent triethyleneglycol (TEG) chains of 2.8 MDa (“2.8M TEG”) was synthesized and evaluated for long-term lubrication and wear reduction of ex vivo bovine cartilage as well as for synovitis in rats and dogs after intra-articular administration. Bovine cartilage surfaces were tested under torsional friction for 10,080 rotations while immersed in either saline, bovine synovial fluid (BSF), or 2.8M TEG. For each solution, coefficient of friction (μ), changes in surface roughness, and lost cartilage glycosaminoglycan were compared. To directly compare 2.8M TEG and BSF, additional samples were tested sequentially in BSF, BSF, 2.8M TEG, and then BSF. Finally, another set of samples were tested twice in saline to induce surface roughness and then tested in BSF, Synvisc, or 2.8M TEG to determine each treatment’s effect on worn cartilage. Next, male Lewis rats were injected in one knee with 2.8M TEG or saline and evaluated for effects on gait, and female beagles were injected with either 2.8M TEG or saline in one knee, and their synovial tissues analyzed for inflammation by H&E staining. Treatment with 2.8M TEG lowers μ, lessens surface roughness, and minimizes glycosaminoglycan loss compared to saline. The 2.8M TEG also reduces μ compared to BSF in pairwise testing and on worn cartilage surfaces. Injection of 2.8M TEG in rat or beagle knees gives comparable effects to treatment with saline, and does not cause significant synovitis.

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Section: Discussionsupporting

confidence: 89%

A Synthetic Bottle-Brush Polyelectrolyte Reduces Friction and Wear of Intact and Previously Worn Cartilage

Lakin

Cooper

Zakaria

et al. 2019

ACS Biomater. Sci. Eng.

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“…One reason for this may be that the relevant changes to the surface morphology with wear are not captured by the surface roughness measurement, as surfaces with similar roughness can have very different morphologies (Figure 5). Similar results were seen by Verberne et al 31 when comparing worn and unworn regions of a single sample of cartilage. Additional studies into how the surface morphology changes with wear and how to measure these changes may be required before profilometric measurements can be used effectively to quantify wear or surface damage.…”

Section: Discussionsupporting

confidence: 87%

Methods to assess in vitro wear of articular cartilage

McGann

Vahdati

Wagner

2012

Proc Inst Mech Eng H

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New orthopedic implants for focal cartilage defects replace only a portion of the articulating joint and wear against the opposing cartilage surface. The objective of this study was to investigate different methodologies to quantify cartilage wear for future use in screening potential implant materials and finishes. In determining the optimal test parameters, two different cartilage surface geometries were compared: smaller specimens had a flat surface, while larger ones made contact in the center but not at the edge owing to the curvature of the articulating surface. The cartilage wear of the two geometries was compared using three different techniques: the collagen worn from the cartilage specimens was assessed with a modified wear factor, the surface damage was made visible with Indian ink and was quantified, and the change in surface roughness was measured. To interpret the experimental results, maximum shear stresses were evaluated with sliding contact finite element models. Although the modified wear factor was considered to be the most accurate assessment of cartilage wear, surface damage was an effective, inexpensive, and quick technique to evaluate potential implant materials. Flat specimens showed excessive wear at the edges owing to a non-physiologic stress concentration, while the larger specimens wore more uniformly across the surface. These results will be applied to future studies evaluating prospective implant materials.

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“…The significant correlation between the change in surface roughness and the visual wear of a specimen offers the potential to use surface roughness measurements as a quick means for evaluating specimen wear. It was previously shown that surface roughness itself does not correlate well with wear [Verberne et al, 2009], but this study demonstrates that the change in surface roughness before and after wear does correlate to the visual wear of the specimen. If validated chemically, changes in surface roughness can be used in future testing to quickly screen proposed implant materials.…”

Section: Evaluation Of Specimen Surface Geometry For Use In Wear Testingcontrasting

confidence: 72%

“…It has previously been found that hydroxyproline content is consistent throughout the depth of cartilage and is thus an adequate means for determining the amount of wear of the tissue during the course of an experiment [Lipshitz et al, 1975]. The weight percent of hydroxyproline was found to be approximately 7.8% throughout the depth of bovine articular cartilage [Verberne et al, 2009]. Further, HPLC measurement of hydroxyproline is sensitive, accurate, and easy to perform.…”

Section: Chemical Analysismentioning

confidence: 93%

Orthopaedic Implant Design and Manufacturing for Traumatic Injuries

Wagner¹

2012

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Techniques for Assessment of Wear Between Human Cartilage Surfaces

Cited by 6 publications

References 0 publications

A Synthetic Bottle-Brush Polyelectrolyte Reduces Friction and Wear of Intact and Previously Worn Cartilage

A Synthetic Bottle-Brush Polyelectrolyte Reduces Friction and Wear of Intact and Previously Worn Cartilage

Methods to assess in vitro wear of articular cartilage

Orthopaedic Implant Design and Manufacturing for Traumatic Injuries

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