Technique for Microfabrication of Polymeric-Based Microchips from an SU-8 Master with Temperature-Assisted Vaporized Organic Solvent Bonding

Koesdjojo, Myra T.; Koch, Corey R.; Remcho, Vincent T.

doi:10.1021/ac802450u

Cited by 41 publications

(34 citation statements)

References 33 publications

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“…Sofla and Martin presented a vapor assisted PDMS to glass substrate bonding method using fluoroalkyl trichlorosilane vapor (56). Vaporized organic solvent and temperature assisted bonding of hard and soft polymer have been reported by Koesdjojo et al and used for HPLC applications (57). The Zengerle group reported bonding of 3D polystyrene microfluidic structures (58).…”

Section: Technologymentioning

confidence: 99%

Latest Developments in Micro Total Analysis Systems

et al. 2010

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The field of micro total analysis systems (µTAS) (1) or lab on a chip (LOC) has extended its usefulness into many new fields and disciplines spanning basic research to commercial applications. The importance of µTAS is reflected in both the growing number and improved quality of published articles. µTAS has expanded into an incredibly diverse number of analytical chemistry applications and has received a great amount of input from a wide spectrum of scientific and engineering disciplines. In this sense, µTAS is highly interdisciplinary and has served as a focal point to bring together multidisciplinary research fields.This work builds on former reviews (2-6) and attempts to chart the most recent developments in µTAS. By cross referencing online keyword searches, several thousand articles were found spread among a wide variety of journals but were most frequently found in the high impact journals such as Science, Nature, PNAS, Analytical Chemistry, Lab on a Chip, and others. The annual international µTAS conference also provided articles on some of the very latest and most promising developments. This review article aims to report the latest achievements in the field of µTAS by highlighting some of the very best research papers published over the 2 year period between March 2008 and February 2010. Our main goal is to give a broad overview of the latest state-ofthe-art research and to introduce newcomers to the field. We were overwhelmed by the large number of research papers published on cellular analysis, manipulation, and droplet fluidics; therefore, we divided the review into two parts. This first part concentrates on reports related to manufacturing, technology, and instrumentation for molecular analysis, and part two covers applications related to cellular analysis and manipulation, which is referred to as cellson-a-chip (460). The papers we selected on droplet fluidics are distributed throughout both parts of the article according to their applications. We attempted to select papers based on the merit of their contents, which was a difficult task, and we have missed some good articles; for these oversights, we offer our apology in advance.Since this review focuses on novel developments of microfluidic systems for applied analytical chemical applications, publications about sensor arrays (so-called "biochips"), chemical synthesis on microchips (except some papers on particle synthesis using droplets), theory, and simulations, as well as trend articles, have been omitted. Furthermore, we reduced the technology section, as the majority of work is carried out by employing simple planar microchips fabricated in glass or polymers such as silicone elastomers. TECHNOLOGYMicrofabrication. Conventional Microfabrication. Many new innovative approaches have been reported in the field of microfabrication. Semicircular cross section channels network microfabricated on a silicon chip by XeF 2 etching by Camp et al. (7). These channels allow stress free transportation of cells. Generally, vapor deposited thin film metal ele...

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Section: Technologymentioning

confidence: 99%

Latest Developments in Micro Total Analysis Systems

et al. 2010

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“…Microchips were fabricated from PMMA using a two-step embossing and solvent welding technique described previously [26,27]. The design of the microchip is shown in Fig.…”

Section: Microfluidic Device Fabricationmentioning

confidence: 99%

In‐line extraction employing functionalized magnetic particles for capillary and microchip electrophoresis

Tennico

Remcho

2010

Electrophoresis

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An approach to performing in-line extraction employing functionalized magnetic particles for CE and microchip electrophoresis is presented. Silica-coated iron oxide particles were synthesized and used as the solid support. The particles were functionalized with octadecylsilane and used as reverse-phase sorbents for in-line SPE followed by electrophoresis. Magnets were used to locally immobilize these sorbents inside the capillary or microchip. Extraction, elution, and detection of the analytes were performed sequentially without interruption or need for sample handling. Mixtures of hydrophobic analytes were successfully extracted from solution using the synthesized magnetic sorbents. CE was able to extract and separate mixture of parabens within 10 min. In-line extraction was also carried out on a disposable PMMA microfluidic device with LIF detection. Electrophoretic separation of fluorescent dyes, Rhodamine 110 and SulfoRhodamine B, was completed in under a minute. The results demonstrated the feasibility of performing the in-line extraction/separation technique in a microchip platform enabling rapid analysis, low sorbent consumption, and increased analyte recovery (relative to the capillary format).

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“…Thermoplastic bonding is one of the most simple and straightforward thermoplastic processes [23]; however, it imparts a low bonding strength. Therefore, high-strength bonding techniques using materials such as solvents [27], adhesives [28], UV/Ozone [29], O2 plasma [30], as well as welding [31] have been reported. Each polymer-replication or bonding technique presents specific advantages as well as process limitations for different applications.…”

Section: Introductionmentioning

confidence: 99%

Thermoplastic Micromodel Investigation of Two-Phase Flows in a Fractured Porous Medium

Hsu

Zhang

Tsao

2017

Preprint

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Abstract:In the past few years, micromodels have become a useful tool for visualizing flow phenomena in porous media with pore structures, e.g., the multifluid dynamics in soils or rocks with fractures in natural geomaterials. Micromodels fabricated using glass or silicon substrates incur high material cost; in particular, the microfabrication-facility cost for making a glass or siliconbased micromold is usually high. This may be an obstacle for researchers investigating the twophase-flow behavior of porous media. A rigid thermoplastic material is a preferable polymer material for microfluidic models because of its high resistance to infiltration and deformation. In this study, cyclic olefin copolymer (COC) was selected as the substrate for the micromodel because of its excellent chemical, optical, and mechanical properties. A delicate micromodel with a complex pore geometry that represents a two-dimensional (2D) cross-section profile of a fractured rock in a natural oil or groundwater reservoir was developed for two-phase-flow experiments. Using an optical visualization system, we visualized the flow behavior in the micromodel during the processes of imbibition and drainage. The results show that the flow resistance in the main channel (fracture) with a large radius was higher than that in the surrounding area with small pore channels when the injection or extraction rates were low. When we increased the flow rates, the extraction efficiency of the water and oil in the mainstream channel (fracture) did not increase monotonically because of the complex two-phase-flow dynamics. These findings provide a new mechanism of residual trapping in porous media.

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Technique for Microfabrication of Polymeric-Based Microchips from an SU-8 Master with Temperature-Assisted Vaporized Organic Solvent Bonding

Cited by 41 publications

References 33 publications

Latest Developments in Micro Total Analysis Systems

Latest Developments in Micro Total Analysis Systems

In‐line extraction employing functionalized magnetic particles for capillary and microchip electrophoresis

Thermoplastic Micromodel Investigation of Two-Phase Flows in a Fractured Porous Medium

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