Technique and Results of Isolation of Cancer Cells From the Circulating Blood

Watne, Alvin L.; Mcgrath, Ruth G.; McGrew, Elizabeth A.; Cole, Warren H.

doi:10.1097/00006254-195810000-00050

Cited by 11 publications

(12 citation statements)

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“…This could be attributed to the possibility that excessive intraoperative blood loss promotes spillage and hematogenous spreading of cancer cells. It might also be caused by the decrease in anticancer immunity and tissue inflammation owing to systemic hypoperfusion …”

Section: Discussionmentioning

confidence: 99%

Survival analysis after liver resection for hepatocellular carcinoma: A consecutive cohort of 1002 patients

Lee

Kim

Park

et al. 2017

J of Gastro and Hepatol

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Section: Discussionmentioning

confidence: 99%

Survival analysis after liver resection for hepatocellular carcinoma: A consecutive cohort of 1002 patients

Lee

Kim

Park

et al. 2017

J of Gastro and Hepatol

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“…5-fluorouracil (5-FU) treatment has been accepted as standard chemotherapy for colorectal cancers for a long time. Recently, high recurrence rates, the presence of distant metastasis, the possibility of complete resection, and the removal of circulating tumour cells after curative resection of colorectal cancers constitute a new therapeutic approach known as neo-adjuvant chemotherapy [5][6][7] . While the integrity of anastomoses after colorectal cancer resection is an important parameter on mortality and morbidity, the effects of preoperative chemotherapy on wound healing and anastomoses are also important and have not been clearly outlined.…”

Section: Introductionmentioning

confidence: 99%

Effect of early preoperative 5-fluorouracil on the integrity of colonic anastomoses in rats

Özel

Özel²,

Toros³

et al. 2009

WJG

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AIM:To determine the effect of chemotherapy on wound healing by giving early preoperative 5-fluorouracil (5-FU) to rats with colonic anastomoses. METHODS:Sixty Albino-Wistar male rats (median weight, 235 g) were used in this study. The rats were fed with standard laboratory food and given tap water ad libitum . The animals were divided into three groups:Group 1: Control group (chemotherapy was not administered), Group 2: Intraperitoneally (IP) administered 5-FU group (chemotherapy was administered IP to animals at a dose of 20 mg/kg daily during the 5 d preceeding surgery), Group 3: Intravenously (IV) administered 5-FU group. Chemotherapy was administered via the penil vein, using the same dosing scheme and duration as the second group. After a 3-d rest to minimize the side effects of chemotherapy, both groups underwent surgery. One centimeter of colon was resected 2 cm proximally from the peritoneal reflection, then sutured intermittently and subsequently end-to-end anastomosed. In each group, half the animals were given anaesthesia on the 3rd postoperative (PO) day and the other half on the 7th PO day, for in vivo analytic procedures. The abdominal incisions in the rats were dissected, all the new and old anastomotic segments were clearly seen and bursting pressures of each anastomotic segment, tissue hydroxyproline levels and DNA content were determined to assess the histologic tissue repair process. RESULTS:When the IV group was compared with the IP group, bursting pressures of the anastomotic segments on the 3rd and 7th PO days, were found to be significantly decreased, hydroxyproline levels at the anastomotic segment on the 7th PO day were significantly decreased (P < 0.01). CONCLUSION:In this study, we conclude that early preoperative 5-FU, administered IV, negatively affects wound healing. However, IP administered 5-FU does not negatively affect wound healing.

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“…[16][17][18][19][20] Such data corroborate classic studies that demonstrate that even after successful surgery for localized tumors; cells can still be detected in the circulation and at distant sites. [21][22][23][24][25] Simultaneously, development of improved techniques for detection and imaging of tumor cells within intact tissues (i.e., fluorescence microscopy, intravital videomicroscopy, cell tracking with quantum dots, etc.) are enabling investigators to visualize and quantify the steps of metastasis in real-time.…”

Section: Molecular and Cellular Aspects Of Metastasis-new Technology mentioning

confidence: 99%

Metastasis suppressor genes: From gene identification to protein function and regulation

Berger¹,

Griend²,

Robinson³

et al. 2005

Cancer Biology & Therapy

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Technique and Results of Isolation of Cancer Cells From the Circulating Blood

Cited by 11 publications

References 0 publications

Survival analysis after liver resection for hepatocellular carcinoma: A consecutive cohort of 1002 patients

Survival analysis after liver resection for hepatocellular carcinoma: A consecutive cohort of 1002 patients

Effect of early preoperative 5-fluorouracil on the integrity of colonic anastomoses in rats

Metastasis suppressor genes: From gene identification to protein function and regulation

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