Technik der isolierten Extremit�tenperfusion

Abstract

In 171 cases of isolated perfusion of the extremities for treatment of melanomas and soft tissue sarcomas, standardized operation techniques were perfected. The arterial double cannulation makes an iliac cannulation feasible also in cases of second and third perfusion. Cytostatics are dosed per liter of perfused extremity. Cis-Platinum and dacarbacine were recently introduced in isolation perfusion treatment. So-called preheating of the extremity before adding the drugs allows administration of cytostatics besides tumortoxic hyperthermia.

Clinical Management and Current Research in Isolated Limb Perfusion for Sarcoma and Melanoma

“…Actinomycin D and mitoxantrone show documented activity but induce severe local toxicity [11]. Dacarbazine has been used by several authors, even though the drug requires activation by hepatic enzymes [12][13][14][15]. Therefore, the response rates achieved might be due to hyperthermic perfusion alone.…”