Technical report: the NIOSH occupational exposure banding process for chemical risk management.

Abstract

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In silico approaches in organ toxicity hazard assessment: Current status and future needs in predicting liver toxicity

“…In silico methods for the prediction of organ toxicity can be integrated into a WoE approach to help establish the point of departure (PoD) (e.g., Benchmark Dose (BMD) or no-observed-adverse-effect-level (NOAEL)) that is relevant for deriving exposure limit values (i.e., observed-effect-levels (OELs)) [36]. In silico methods can also complement the toxicological profile of data poor-substances in support of the overall risk assessment/management in cases where OEL are absent such as in the context of the Occupational Exposure Banding (OEB) process [37].…”

A Cumulative Risk Perspective for Occupational Health and Safety (OHS) Professionals

“…It is important to recognize that the magnitude of voluntary reductions is not a precise or pre-defined level based on known dose-response data and will require judgements and acceptance by the OHS practitioner, the organization's management, and others on a site-by-site basis (e.g., process engineer, medical personnel, etc.). Risk management approaches, such as NIOSH's process for occupational exposure banding, which is largely based on the Globally Harmonized System for Classification and Labelling of Chemicals (GHS) hazard codes, and NIOSH TWH guidelines may provide useful frameworks for establishing target exposure control limits or ranges to reduce risks among workers from combined exposures when there are limited toxicological data [113]. Greater adoption of a CRA approach can also improve existing tools available through the TWH program by helping to identify those co-exposures of greatest concern, and hence in greatest need of risk management action, in specific occupations or industry sectors.…”

Separation of aniline from water and wastewater samples based on activated carbon nanoparticles and dispersive solid phase extraction procedure

“…Also, the acute exposure aniline has toxic reaction in the spleen or liver and cause to splenomegaly, hyperplasia, fibrosis, and cancers with chronic exposure [8]. The toxicity and carcinogenicity of aniline was reported by NIOSH and OSHA [9][10][11]. The acute toxicity of aniline caused to convert to 4-hydroxyaniline and the formation of aniline compound with hemoglobin (Hb).…”