Technical Note: Thermoacoustic imaging of hemorrhagic stroke: A feasibility study with a human skull

Huang, Lin; Li, Tingting; Jiang, Huabei

doi:10.1002/mp.12138

Cited by 43 publications

(26 citation statements)

References 16 publications

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“…As previously reported, the variations in tissue water content and ion concentration induce the alternations of local conductivity and dielectric properties, which serves as the contrast mechanism for TAI. It has been documented that cancer tissue and blood are more microwave absorbant than the surrounding normal tissue due to its higher water or ionic concentration. Thus, TAI has attracted considerable research interest in recent years, and offers great potential for breast cancer detection, prostate cancer detection, brain imaging, and other clinically valuable imaging applications .…”

Section: Introductionmentioning

confidence: 53%

“…To reduce the significant distortion caused by the effect of microwave attenuation especially for deep tissue imaging, we sought to consider the microwave attenuation effect in our reconstruction algorithm. We corrected our linear array‐based delay‐and‐sum reconstruction algorithm using the attenuation factor 1/ r 2 , and attempted to recover the TA images of targets 2–4 using both the open‐ended waveguide and handheld dipole antenna illuminations. Briefly, the electric field attenuation can be corrected as follows: First, the TA images was recovered without compensation as shown in Figs.…”

Section: Resultsmentioning

confidence: 99%

“…TAI employs significantly longer wavelengths (e.g.,~10 cm, at 3 GHz), and thus can provide greater penetration depths than PAI. As previously reported, [5][6][7][8][9] the variations in tissue water content and ion concentration induce the alternations of local conductivity and dielectric properties, which serves as the contrast mechanism for TAI. It has been documented that cancer tissue [5][6][7][8] and blood 9 are more microwave absorbant than the surrounding normal tissue due to its higher water or ionic concentration.…”

Section: Introductionmentioning

confidence: 91%

“…Although multichannel data acquisition and transducer array‐based TAI systems with a bulky antenna have been developed, at present it is difficult to translate them into clinical settings because the use of a bulky antenna allows very limited access to the tissue types/organ sites for TAI imaging. A TAI system with a portable antenna will permit TAI to be realized in reflection‐mode, which could be used for imaging many tissue types/organ sites, or such a TAI system could also be conveniently utilized in an ambulance or bedside . On the other hand, a portable TA excitation source is also important for a portable TAI system.…”

Section: Introductionmentioning

confidence: 99%

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Technical Note: Design of a handheld dipole antenna for a compact thermoacoustic imaging system

Huang

Zhu

et al. 2018

Medical Physics

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Purpose Conventional antenna used in thermoacoustic imaging (TAI) is often bulky, making it difficult to translate TAI from the bench to the clinic. In this paper, we proposed a handheld dipole antenna which will be a good candidate for the construction of a compact TAI system. Methods Here, we propose a TAI system based on a handheld dipole antenna with an aperture of 6 cm and a weight of 230 g. Compensation of the electric field attenuation for such a system was also investigated. Results Compared to the conventional open‐ended waveguide and pyramidal horn antenna used in TAI, our results reveal that the electric field attenuation induced distortion is effectively reduced by using the attenuation factor 1/r2 for compensation and that the handheld dipole antenna provides the highest efficiency of microwave delivery. Conclusions This study suggests that the handheld dipole antenna has the potential to be utilized for the construction of a compact TAI system, making TAI more suitable for preclinical and clinical applications.

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Section: Introductionmentioning

confidence: 53%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 91%

Section: Introductionmentioning

confidence: 99%

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Technical Note: Design of a handheld dipole antenna for a compact thermoacoustic imaging system

Huang

Zhu

et al. 2018

Medical Physics

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“…The spatial resolution of this system is estimated to be about 0.9 mm (Ref. 33) due to limitation by the pulse width of the microwave generator. The resolution is an important improvement that needs to be undertaken by using a shorter-width nanosecond microwave pulse generator in the future.…”

Section: Electric¯eld Polarization On Imaging Contrastmentioning

confidence: 99%

Thermoacoustic tomography of in vivo rat brain

Zhao

Chi

Huang

et al. 2017

J. Innov. Opt. Health Sci.

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We present for the¯rst time in vivo imaging of rat brain using microwave-induced thermoacoustic tomography (TAT). The in vivo imaging of rat brain was realized through an unconventional delivery of microwave energy from the front of rat brain (while the transducer was scanned along coronal plane of the animal brain), which maximized the microwave penetration into the brain. In addition, we found that the imaging contrast was highly dependent on the direction of the electric¯eld polarization (EFP) and that more tissue structures/compositions could be revealed when both X-and Y -EFPs were used for TAT. The in vivo TAT images of rat brain obtained were compared with the 3.0 T MRI images and histological photographs, and numerous important brain anatomical structures were identi¯ed. An example of our TAT approach for imaging a foreign object embedded in a rat brain was also demonstrated. This study suggests that TAT has a great potential to be used in neuroscience studies and in noninvasive imaging of brain disorders.

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Microwave‐induced thermoacoustic tomography through an adult human skull

Lin

Liu

et al. 2019

Medical Physics

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Purpose: To demonstrate the feasibility of microwave-induced thermoacoustic tomography (TAT) of adult human brain. Methods: We analyzed the electric field distribution radiated from an antenna to acquire homogeneous illumination. We first imaged the anatomical structures in a rat's trunk to validate the thermoacoustic contrast in vivo. We then imaged an agar cylinder through an adult human skull ex vivo to demonstrate transcranial penetration of both microwave and ultrasound. We also analyzed the specific absorption rate to show the conformance to the safety standard for human electromagnetic exposure. Results: We successfully acquired cross-sectional images of the rat's trunk in vivo. Major blood vessels and organs are clearly visible. The transcranial image shows that TAT can image through the adult human skull and reveal an agar enclosed by the skull. Conclusions: Microwave-induced TAT of a rat's trunk in vivo and an agar phantom through an adult human skull ex vivo has been demonstrated experimentally. This study demonstrates both the TAT contrasts in vivo and the capability of transcranial imaging, showing potential of TAT for adult human brain imaging with high contrast and penetration.

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Technical Note: Thermoacoustic imaging of hemorrhagic stroke: A feasibility study with a human skull

Abstract: This study suggests that TAI has the potential to be used for noninvasive hemorrhagic stroke detection and identification of hemorrhagic from ischemic stroke.

Cited by 43 publications

References 16 publications

Technical Note: Design of a handheld dipole antenna for a compact thermoacoustic imaging system

Technical Note: Design of a handheld dipole antenna for a compact thermoacoustic imaging system

Thermoacoustic tomography of in vivo rat brain

Microwave‐induced thermoacoustic tomography through an adult human skull

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