Technical Note: On maximizing Cherenkov emissions from medical linear accelerators

Shrock, Zachary; Yoon, Paul; Gunasingha, Rathnayaka; Oldham, Mark; Adamson, Justus

doi:10.1002/mp.12927

Cited by 3 publications

(1 citation statement)

References 31 publications

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“…The effect of the flattening filter was also studied. According to a recent publication [24], the efficiency of Cherenkov emission per dose increases when a filter is applied. Such a conclusion was validated by Vis-NIR as well as NIR-II imaging results as shown in Fig.…”

Section: Nir-ii Cherenkov In Dosimetrymentioning

confidence: 99%

Cherenkov excited luminescence imaging induced by megavolt X-ray beams in the second near-infrared window

Meng

Wang

et al. 2019

Optics Communications

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Although the Cherenkov light contains mostly short-wavelength components, it is beneficial in the aspect of imaging to visualize it in the second near-infrared (NIR-II) window. In this study, Cherenkov imaging was performed within the NIR-II range on megavolt X-ray beams delivered by a medical linear accelerator. A shielding system was used to reduce the noises of the NIR-II image, enabling high quality signal acquisition. It was demonstrated that the NIR-II Cherenkov imaging is potentially a tool for radiotherapy dosimetry, and correlates well with different parameters. The NIR-II Cherenkov imaging is less susceptible to scattering, while more susceptible to absorption, compared with the visible-near-infrared imaging. Finally, a mouse was used to demonstrate this technology on animals. These results indicate the potentials to apply NIR-II Cherenkov imaging in the practice of radiotherapy.

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Section: Nir-ii Cherenkov In Dosimetrymentioning

confidence: 99%

Cherenkov excited luminescence imaging induced by megavolt X-ray beams in the second near-infrared window

Meng

Wang

et al. 2019

Optics Communications

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Probing nanostructures under irradiation: Developing a charged particle induced luminescence based chemical sensing methodology

Morrison

Hawkins

Ghandi

2023

Chemical Physics Letters

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Cherenkov Luminescence in Tumor Diagnosis and Treatment: A Review

Wang

et al. 2022

Photonics

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Malignant tumors rank as a leading cause of death worldwide. Accurate diagnosis and advanced treatment options are crucial to win battle against tumors. In recent years, Cherenkov luminescence (CL) has shown its technical advantages and clinical transformation potential in many important fields, particularly in tumor diagnosis and treatment, such as tumor detection in vivo, surgical navigation, radiotherapy, photodynamic therapy, and the evaluation of therapeutic effect. In this review, we summarize the advances in CL for tumor diagnosis and treatment. We first describe the physical principles of CL and discuss the imaging techniques used in tumor diagnosis, including CL imaging, CL endoscope, and CL tomography. Then we present a broad overview of the current status of surgical resection, radiotherapy, photodynamic therapy, and tumor microenvironment monitoring using CL. Finally, we shed light on the challenges and possible solutions for tumor diagnosis and therapy using CL.

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Technical Note: On maximizing Cherenkov emissions from medical linear accelerators

Abstract: Through a combination of increasing photon energy and applying specialized beam-hardening filtration, the amount of Cherenkov photons per unit radiotherapy dose can be increased substantially.

Cited by 3 publications

References 31 publications

Cherenkov excited luminescence imaging induced by megavolt X-ray beams in the second near-infrared window

Cherenkov excited luminescence imaging induced by megavolt X-ray beams in the second near-infrared window

Probing nanostructures under irradiation: Developing a charged particle induced luminescence based chemical sensing methodology

Cherenkov Luminescence in Tumor Diagnosis and Treatment: A Review

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