Technical feasibility proof for high-resolution low-dose photon-counting CT of the breast

Kalender, Willi A.; Kolditz, Daniel; Steiding, Christian; Ruth, Veikko; Lück, Ferdinand; Rößler, Ann-Christin; Wenkel, Evelyn

doi:10.1007/s00330-016-4459-3

Cited by 80 publications

(84 citation statements)

References 8 publications

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“…In this previous study, it has been demonstrated that the system can achieve a spatial isotropic resolution of better than 5 line pairs/mm corresponding to better than 100 μm resolution, with low noise level and under the maximal permitted level of dose exposition. 15 The high resolution, but also the possibility to evaluate the images in different planes, increases and facilitates the characterization of lesions regarding suspicious features such as conspicuity, calcifications, and asymmetries, as well as masses. 14,22,23 Due to the retrospective nature of our study, no mammography was performed in addition to B-CT, and previous mammography was available only in a limited number of cases, thus precluding a systematic 2 1 5555 5 5 4444 3 3 4545 3 3 4444 3 3 2 5555N M N M4455N M N M5545N M N M5444N M N M 3 5555 5 5 4455 4 4 4444 4 4 5544 3 3 4 5555N comparison.…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, based on preliminary studies, all examinations were performed with a tube current of 25 mA with the aim to keep radiation dose at similar level to screening mammography. 15,16 For image reconstructions, a Feldkamp-type filtered back-projection algorithm was used by the nu:view reconstruction software. A smooth kernel (300 μm 3 ) voxel size and 4 Â 4 detector binning were used for ST image reconstruction.…”

Section: Dedicated Breast Ct Systemmentioning

confidence: 99%

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Dedicated Breast Computed Tomography With a Photon-Counting Detector

et al. 2019

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OBJECTIVES: The purpose of this work is to present the data obtained from the first clinical in vivo application of a new dedicated spiral breast computed tomography (B-CT) equipped with a photon-counting detector. MATERIALS AND METHODS: The institutional review board approved this retrospective study. Twelve women referred for breast cancer screening were included and underwent bilateral spiral B-CT acquired in prone position. Additional sonography was performed in case of dense breast tissue or any B-CT findings. In 3 women, previous mammography was available for comparison. Soft tissue (ST) and high-resolution (HR) images were reconstructed. Two independent radiologists performed separately the readout for subjective image quality and for imaging findings detection. Objective image quality evaluation was performed in consensus and included spatial resolution, contrast resolution, signal-to-noise ratio (SNR), and contrast-to-noise ratio. All women were asked to report about positioning comfort and overall comfort during data acquisition. RESULTS: The major pectoral muscle was included in 15 breast CT scans (62.5%); glandular component was partially missing in 2 (8.3%) of the 24 scanned breasts. A thin "ring artifact" was present in all scans but had no influence on image interpretations; no other artifacts were present. Subjective image quality assessment showed excellent agreement between the 2 readers (= 1). Three masses were depicted in B-CT and were confirmed as simple cysts in sonography. Additional 5 simple cysts and 2 solid benign lesions were identified only in sonography. A total of 12 calcifications were depicted with a median size of 1.1 mm (interquartile range, 0.7-1.7 mm) on HR and 1.4 mm (interquartile range, 1.1-1.8 mm) on ST images. Median SNRgl, SNRfat, and contrast-to-noise ratio were significantly higher in ST than in HR reconstructions (each, P < 0.001). A mild discomfort due to positioning of the rib cage on the table was reported by 2 women (16.7%); otherwise, no discomfort was reported. CONCLUSIONS: The new dedicated B-CT equipped with a photon-counting detector provides high-quality images with potential for screening of breast cancer along with minor patient discomfort.

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Section: Discussionmentioning

confidence: 99%

Section: Dedicated Breast Ct Systemmentioning

confidence: 99%

Dedicated Breast Computed Tomography With a Photon-Counting Detector

et al. 2019

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“…8) compares relatively well with the resolution (1.4 lp/ mm) of the first two generations of the UC Davis CT scanners (their Bodega and Cambria systems 56 ), but lower than the latest generation scanner (their Doheny system (3.6 lp/mm 56 )), and the system that utilizes a photon counting x ray detector constructed by the Erlangen group operated in "standard mode" (2 9 2 detector binning) (1.4 lp/mm). 32 The resolution is moderately lower than the FDA-approved scanner (1.6 lp/mm 57 ). Our system's resolution is much lower than the Erlangen group's scanner operated in "lCa mode", which utilizes 1 9 1 detector binning and a high-resolution reconstruction kernel (5.3 lp/mm 32 ) and the phase-contrast scanner developed by the University of Napoli group that utilizes synchrotron radiation (6.4 lp/mm).…”

Section: Discussionmentioning

confidence: 96%

A dedicated breast‐PET/CT scanner: Evaluation of basic performance characteristics

et al. 2018

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The basic performance characteristics of a new dedicated breast-PET/CT scanner are good, demonstrating that its performance is similar to current dedicated PET and CT scanners. The potential value of this system is the capability to produce combined duality-modality images that could improve detection of breast disease. The next stage in development of this system is testing with more advanced phantoms and human subjects.

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“…In addition, it highlights the many combinations of modalities, including several promising combinations that could bring QMIB into the clinic (Table 3). 27,60,72,99,113…”

Section: Quantitative Multiscale Imaging Of the Breast Modalitiesmentioning

confidence: 99%

“…115 By comparison, μCT has not yet reached breast imaging clinically due to technological and radiation dose limitations. 115 Several groups are addressing these issues with new systems that can perform whole-breast μCT; 50,60,62 however, they impart radiation dose 2× to 3× that produced from clinical mammography or digital breast tomosynthesis systems. 60,116 Thus, preclinical and clinical μCT may both prove valuable tools for future QMIB studies.…”

Section: Microcomputed Tomographymentioning

confidence: 99%

Review of quantitative multiscale imaging of breast cancer

et al. 2018

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Breast cancer is the most common cancer among women worldwide and ranks second in terms of overall cancer deaths. One of the difficulties associated with treating breast cancer is that it is a heterogeneous disease with variations in benign and pathologic tissue composition, which contributes to disease development, progression, and treatment response. Many of these phenotypes are uncharacterized and their presence is difficult to detect, in part due to the sparsity of methods to correlate information between the cellular microscale and the whole-breast macroscale. Quantitative multiscale imaging of the breast is an emerging field concerned with the development of imaging technology that can characterize anatomic, functional, and molecular information across different resolutions and fields of view. It involves a diverse collection of imaging modalities, which touch large sections of the breast imaging research community. Prospective studies have shown promising results, but there are several challenges, ranging from basic physics and engineering to data processing and quantification, that must be met to bring the field to maturity. This paper presents some of the challenges that investigators face, reviews currently used multiscale imaging methods for preclinical imaging, and discusses the potential of these methods for clinical breast imaging.

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Technical feasibility proof for high-resolution low-dose photon-counting CT of the breast

Abstract: • Photon-counting detector technology allows for spatial resolution better than 100 μm. • pcBCT allows for dose levels in the screening mammography range. • pcBCT provides the highest quality imaging of microcalcifications.

Cited by 80 publications

References 8 publications

Dedicated Breast Computed Tomography With a Photon-Counting Detector

Dedicated Breast Computed Tomography With a Photon-Counting Detector

A dedicated breast‐PET/CT scanner: Evaluation of basic performance characteristics

Review of quantitative multiscale imaging of breast cancer

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