Technical Design Report: Scientific Instrument MID

Madsen, Anders; Roth, Thomas; Ansaldi, Gabriele; Hallmann, Johannes

doi:10.3204/xfel.eu/tr-2013-005

Cited by 5 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This new generation of highly efficient and robust x-ray optical elements has been designed to operate under the full beam conditions of these sources 6,7 . Part of this work was done during the commissioning of the MID beamline 8,9 of the European XFEL 10 (Schenefeld, Germany) in two experimental runs . In general, focusing x-ray beams to a very small spot, below 10 nm, is challenging.…”

Section: Introductionmentioning

confidence: 99%

On the use of multilayer Laue lenses with X-ray free electron lasers

Prasciolu

Murray

Ivanov

et al. 2021

International Conference on X-Ray Lasers 2020

Self Cite

View full text Add to dashboard Cite

show abstract

Section: Introductionmentioning

confidence: 99%

On the use of multilayer Laue lenses with X-ray free electron lasers

Prasciolu

Murray

Ivanov

et al. 2021

International Conference on X-Ray Lasers 2020

Self Cite

View full text Add to dashboard Cite

show abstract

“…Various optics in the beampath between the instrument and the undulator [Mad+13] can introduce aberrations to the XFEL beam, which lead to a broadening of the focus and to a degradation of the resolution.…”

Section: Spatial Resolutionmentioning

confidence: 99%

A matter of brightness: table-top X-ray generation inside waveguides and X-ray holography with single free-electron laser pulses

Vassholz¹

View full text Add to dashboard Cite

Date of the oral examination: 26.03.2021 Contents 1 Introduction 2 Observation of electron-induced characteristic X-ray and bremsstrahlung radiation from a waveguide cavity 3 Pump-probe X-ray holographic imaging of laser-induced cavitation bubbles with femto-second FEL pulses 4 Structural dynamics of water after dielectric breakdown 5 Conclusion and outlook A Appendix Bibliography Author contributions List of publications Acknowledgements 1.1.1 Propagation-based phase contrast imaging Dennis Gabor's invention of holography [Gab48; GB49] is the basis for X-ray near-field holography or propagation-based phase contrast imaging. As a phase-sensitive imaging Requirements for propagation-based phase contrast imagingLet us consider a cone-beam setup with an incoherent source of finite source size σ s and let us assume a detector with finite resolution σ d . We will now estimate which structure sizes p are resolvable and exhibit phase contrast under experimental conditions of partial lateral coherence and limited detector resolution. While we aim at equipping the reader with an intuitive understanding of the key aspects, we refer to several studies [PGW97; WL04; WL07; HS18] treating the topic in detail. in the limit of thick anodes [GWA86]. A minimal source size using thick anodes is imposed by multiple scattering of electrons, however. Thin anodes as commonly used in transmission target X-ray tubes allow for smaller source spots, but only at the cost of further reducing the flux [Beh16]. In conclusion, all three options to increase the range for structure sizes p accessible with phase contrast decrease the photon flux.

show abstract

A split-beam probe-pump-probe scheme for femtosecond time resolved protein X-ray crystallography

Thor

Madsen

2015

Structural Dynamics

Self Cite

View full text Add to dashboard Cite

In order to exploit the femtosecond pulse duration of X-ray Free-Electron Lasers (XFEL) operating in the hard X-ray regime for ultrafast time-resolved protein crystallography experiments, critical parameters that determine the crystallographic signal-to-noise (I/σI) must be addressed. For single-crystal studies under low absorbed dose conditions, it has been shown that the intrinsic pulse intensity stability as well as mode structure and jitter of this structure, significantly affect the crystallographic signal-to-noise. Here, geometrical parameters are theoretically explored for a three-beam scheme: X-ray probe, optical pump, X-ray probe (or “probe-pump-probe”) which will allow experimental determination of the photo-induced structure factor amplitude differences, ΔF, in a ratiometric manner, thereby internally referencing the intensity noise of the XFEL source. In addition to a non-collinear split-beam geometry which separates un-pumped and pumped diffraction patterns on an area detector, applying an additional convergence angle to both beams by focusing leads to integration over mosaic blocks in the case of well-ordered stationary protein crystals. Ray-tracing X-ray diffraction simulations are performed for an example using photoactive yellow protein crystals in order to explore the geometrical design parameters which would be needed. The specifications for an X-ray split and delay instrument that implements both an offset angle and focused beams are discussed, for implementation of a probe-pump-probe scheme at the European XFEL. We discuss possible extension of single crystal studies to serial femtosecond crystallography, particularly in view of the expected X-ray damage and ablation due to the first probe pulse.

show abstract

Technical Design Report: Scientific Instrument MID

Cited by 5 publications

References 0 publications

On the use of multilayer Laue lenses with X-ray free electron lasers

On the use of multilayer Laue lenses with X-ray free electron lasers

A matter of brightness: table-top X-ray generation inside waveguides and X-ray holography with single free-electron laser pulses

A split-beam probe-pump-probe scheme for femtosecond time resolved protein X-ray crystallography

Contact Info

Product

Resources

About