Technical and Diagnostic Issues in Whole Slide Imaging Published Validation Studies

Rizzo, Paola Chiara; Girolami, Ilaria; Marletta, Stefano; Pantanowitz, Liron; Antonini, Pietro; Brunelli, Matteo; Nicola, Santonicco; Vacca, Paola; Tumino, Nicola; Moretta, Lorenzo; Parwani, Anil V.; Satturwar, Swati; Eccher, Albino

doi:10.3389/fonc.2022.918580

Cited by 15 publications

(7 citation statements)

References 45 publications

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“…WSI acquisition problems are well‐known to hinder the widespread use of digital cytopathology. Whilst scan failure is a recognised technical issue for histology specimens, 20 this is particularly true for cytology smears because they contain three‐dimensional cellular groups and often have obscuring material. Z ‐stacking (i.e.…”

Section: Discussionmentioning

confidence: 99%

Delphi expert consensus for whole slide imaging in thyroid cytopathology

Marletta,

Salatiello,

Pantanowitz

et al. 2023

Cytopathology

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ObjectiveDespite an increase in thyroid fine needle aspiration (FNA) and advances in whole slide imaging (WSI) adoption, digital pathology is still considered inadequate for primary diagnosis of these cases. Herein, we aim to validate the utility of WSI in thyroid FNAs employing the Delphi method strategy.MethodsA panel of experts from seven reference cytology centres was recruited. The study consisted of two consecutive rounds: (1) an open‐ended, free‐response questionnaire generating a list of survey items; and (2) a consensus analysis of 80 selected shared WSIs from 80 cases by six investigators answering six morphological questions utilising a 1 to 5 Likert scale.ResultsHigh consensus was achieved for all parameters, with an overall average score of 4.27. The broad majority of items (84%) were ranked either 4 or 5 by each physician. Two badly scanned cases were responsible for more than half of the low‐ranked (≤2) values (57%). Good to excellent (≥3) diagnostic confidence was reached in more than 95.2% of cases. For most cases (78%) WSI assessment was not limited by technical issues linked to the image acquisition process.ConclusionThis systematic Delphi study indicates broad consensus among participating physicians on the application of DP to thyroid cytopathology, supporting expert opinion that WSI is reliable and safe for primary diagnostic purposes.

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Section: Discussionmentioning

confidence: 99%

Delphi expert consensus for whole slide imaging in thyroid cytopathology

Marletta,

Salatiello,

Pantanowitz

et al. 2023

Cytopathology

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“…Further publications are necessary to support this transformation, specifically clinical validation studies. 45 …”

Section: Discussionmentioning

confidence: 99%

Digital pathology world tour

Rizzo,

Caputo,

Maddalena

et al. 2023

DIGITAL HEALTH

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Objective Digital pathology (DP) is currently in the spotlight and is rapidly gaining ground, even though the history of this field spans decades. Despite great technological progress, the adoption of DP for routine clinical diagnostic use remains limited. Methods A systematic search was conducted in the electronic databases Pubmed-MEDLINE and Embase. Inclusion criteria were all published studies that encompassed any application of DP. Results Of 4888 articles retrieved, 4041 were included. Relevant articles were categorized as “diagnostic” (147/4041, 4%) where DP was utilized for routine diagnostic workflow and “non-diagnostic” (3894/4041, 96%) for all other applications. The “non-diagnostic” articles were further categorized according to DP application including “artificial intelligence” (33%), “education” (5%), “narrative” (17%) for reviews and editorials, and “technical” (45%) for pure research publications. Conclusion This manuscript provided temporal and geographical insight into the global adoption of DP by analyzing the published scientific literature.

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“…In this respect, the Bioresource Research Impact Factor/Framework (BRIF) initiative was proposed for transparency and to promote the responsible and effective use of biomaterials (Cambon-Thomsen, 2003). Another point that is worth mentioning is related to the integration of artificial intelligence (AI) and machine learning into modern biobanks (Kinkorová and Topolčan, 2020;Eccher et al, 2021;Narita et al, 2021;Rizzo et al, 2022). This would allow for the integration of a digitalized database with digital pathology and high throughput molecular data, potentially representing a quantum leap in biobanking.…”

Section: Discussionmentioning

confidence: 99%

Standard operating procedures for biobank in oncology

Bonizzi

Zattoni

Capra

et al. 2022

Front. Mol. Biosci.

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Biobanks are biorepositories that collect, process, store, catalog, and distribute human biological samples, and record the associated data. The role and action field of these strategic infrastructures for implementing precision medicine in translational research is continuously evolving. To ensure the optimal quality at all stages of biobanking, specific protocols are required and should be elaborated according to updated guidelines, recommendations, laws, and rules. This article illustrates the standard operating procedures, including protocols, troubleshooting, and quality controls, of a fully certified biobank in a referral Cancer Center. This model involves all clinical departments and research groups to support the dual mission of academic cancer centers, i.e. to provide high-quality care and high-quality research. All biobanking activities based on the type of biological specimens are detailed and the most tricky methodological aspects are discussed, from patients’ informed consent to specimen management.

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Technical and Diagnostic Issues in Whole Slide Imaging Published Validation Studies

Cited by 15 publications

References 45 publications

Delphi expert consensus for whole slide imaging in thyroid cytopathology

Delphi expert consensus for whole slide imaging in thyroid cytopathology

Digital pathology world tour

Standard operating procedures for biobank in oncology

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