Technetium(I) carbonyl complexes for nuclear medicine: Coordination-chemical aspect

Sidorenko, G. V.; Miroslavov, A. E.; Tyupina, M. Yu.

doi:10.1016/j.ccr.2022.214911

Cited by 12 publications

(13 citation statements)

References 511 publications

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“…1 H NMR spectrum (CDCl 3 , δ, ppm; the atom numbering is the same as in Figure ): 8.855 d (2H, H bipy4,13 , 3 J 6.0 Hz), 8.59 d (2H, H bipy7,10 , 3 J 8.0 Hz), 8.34 t (2H, H bipy5,12 , 3 J 6.0 Hz), 7.65 t (2H, H bipy6,11 , 3 J 6.0 Hz), 4.48 s (2H, CN–C H 2 –COO−), 4.20 q (2H, C H 2 –CH 3 , 3 J 8.0 Hz), 1.25 t (3H, –C H 3 , 3 J 8.0 Hz). 13 C{ 1 H} NMR spectrum (CDCl 3 , δ, ppm): 163.2 (1C, –COO−), 155.3 (2C, bipy , ), 153.0 (2C, bipy , ), 140.6 (2C, bipy , ), 127.4 (2C, bipy , ), 125.1 (2C, bipy , ), 63.2 (1C, –O– C H 2 –CH 3 ), 46.2 (1C, CN– C H 2 –COO−), 13.9 (1C, –O–CH 2 – C H 3 ). Calculated for [C 18 H 15 N 3 O 5 Tc](ClO 4 ), %: C 39.25, H 2.75, N 7.63, 99 Tc 17.79.…”

Section: Methodsmentioning

confidence: 99%

“…Since the discovery of the [ 99m Tc(CO) 3 (H 2 O) 3 ] + cation as a versatile bioconjugate precursor and the development of a simple procedure for its generation, the technetium tricarbonyl core has found wide use in studies aimed at the development of new pharmaceuticals. − Although the majority of studies are being performed using tridentate chelators, 2 + 1 (bidentate + monodentate) ligand systems also attract researchers’ attention. Among monodentate ligands for implementing the 2 + 1 B approach (tethering of a biomolecule via monodentate ligand), isonitriles seem to be the best choice , owing to the favorable combination of σ-donor and π-acceptor properties (ensuring high stability of the complexes), low steric demand, good complexation kinetics, and versatility in linking to biomolecules.…”

Section: Introductionmentioning

confidence: 99%

“…8.855 d (2H, H bipy4,13 , 3 J 6.0 Hz), 8.59 d (2H, H bipy7,10 , 3 J 8.0 Hz), 8.34 t (2H, H bipy5,12 , 3 J 6.0 Hz), 7.65 t (2H, H bipy6,11 , 3 J 6.0 Hz), 4.48 s (2H, CN− CH 2 −COO−), 4.20 q (2H, CH 2 −CH 3 , 3 J 8.0 Hz), 1.25 t (3H, −CH 3 , 3 J 8.0 Hz) 13. C{ 1 H} NMR spectrum (CDCl 3 , δ, ppm): 163.2 (1C, −COO−), 155.3 (2C, bipy8,9 ), 153.0 (2C, bipy4,13 ), 140.6 (2C, bipy6,11 ), 127.4 (2C, bipy5,12 ), 125.1 https://doi.org/10.1021/acs.inorgchem.3c02204 Inorg. Chem.…”

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confidence: 99%

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2 + 1 Tricarbonyl Complexes of Technetium(I) with a Combination of N,N-Bidentate Ligands and Ethyl Isocyanoacetate: How Strong Is the Interfering Effect of Chloride Ions on Their Formation?

Sidorenko,

Miroslavov,

Tyupina

et al. 2023

Inorg. Chem.

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Technetium(I) 2 + 1 tricarbonyl complexes with a combination of N,N-bidentate ligands (2,2′-bipyridine, bipy; 1,10phenanthroline, phen) and ethyl isocyanoacetate were prepared and characterized by NMR, IR, UV/visible, and luminescence spectroscopies and by high-performance liquid chromatography (HPLC). The crystal structures of [ 99 Tc(CO) 3 (bipy)(CNCH 2 COOEt)](ClO 4 ) (in the form of a solvate with 0.5CH 2 Cl 2 ) and [ 99 Tc(CO) 3 (phen)-(CNCH 2 COOEt)](ClO 4 ) (in the form of an adduct with an outersphere phen molecule) were determined by single-crystal X-ray diffraction. To evaluate the interfering effect of chloride ions on the formation of the 2 + 1 complexes, the kinetics of the replacement of labile monodentate ligand X in the complexes [MX(CO) 3 (N ∧ N)] (M = Re, 99 Tc; N ∧ N = bipy, phen; X = Cl − , ClO 4 − ) by CNCH 2 COOEt in ethanol were compared. The 99 Tc bipy complexes with X = ClO 4 − (according to the IR data, perchlorate anion in ethanol is displaced from the coordination sphere by the solvent molecule) and X = Cl − are characterized by close ligand replacement rates. In the case of the 99 Tc complexes with phen and Re complexes with both phen and bipy, the chloride complexes are appreciably less reactive than the chloride-free complexes. The technetium complexes are considerably more reactive in ligand replacement than their rhenium analogues. In the chloride-containing medium (saline), the complex [ 99m Tc(CO) 3 (bipy)(CNCH 2 COOEt)] + can be prepared under the conditions acceptable for nuclear medical applications, although higher isonitrile concentrations are required as compared to the chloride-free system.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

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2 + 1 Tricarbonyl Complexes of Technetium(I) with a Combination of N,N-Bidentate Ligands and Ethyl Isocyanoacetate: How Strong Is the Interfering Effect of Chloride Ions on Their Formation?

Sidorenko,

Miroslavov,

Tyupina

et al. 2023

Inorg. Chem.

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“…The results of molecular modeling showed that the presence of the 5'-bridging phosphodiester appears to stabilize the HH conformer, as described previously for related Pt and Rh complexes. [57] The effects of the exposure of φX174 plasmid DNA to increasing concentrations of com-plexes fac-[Re(OH 2 ) 3 (CO) 3 ] + and fac-[Re(dmg)(CO) 3 ] 3 (8) were studied by gel electrophoresis methods. [55] The obtained gel electrophoretograms showed that these compounds interfere with the tertiary structure of the DNA by altering the electrophoretic mobility of the open circular and the supercoiled forms.…”

Section: Rhenium Complexes Acting As Covalent Dna Bindersmentioning

confidence: 99%

DNA‐Targeted Complexes of Tc and Re for Biomedical Applications

Palma,

Santos,

Fernandes

et al. 2024

Chemistry A European J

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Due to their favorable chemical features, Re and Tc complexes have been widely used for the development of new therapeutic agents and imaging probes to solve problems of biomedical relevance. This review provides an update of the most relevant research efforts towards the development of novel cancer theranostic agents using Re and Tc‐based compounds interacting with specific DNA structures. This includes a variety of homometallic complexes, namely those containing M(CO)3 (M = Re, Tc) moieties, that exhibit different modes of interaction with DNA, such as covalent binding, intercalation, groove binding or G‐quadruplex DNA binding. Additionally, heterometallic complexes, designed to potentiate synergistic effects of different metal centers to improve DNA‐targeting, cytotoxicity and fluorescence properties, are also reviewed. Particular attention is also given to 99mTc‐ and 188Re‐labeled oligonucleotides that have been widely explored to develop imaging and therapeutic radiopharmaceuticals through the in vivo hybridization with a specific complementary DNA or RNA target sequence to provide useful molecular tools in precision medicine for cancer diagnosis and treatment. Finally, the need for further improvement of DNA‐targeted Re and Tc‐based compounds as potential therapeutic and diagnostic agents is highlighted, and future directions are discussed.

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“…12,13 Under specific conditions, technetium also forms carbonyl-halide compounds that could be precursors for various radiopharmaceuticals. [14][15][16] Nevertheless, the chemistry of technetium is studied less and less every year 17 in favor of its analogue rhenium, which can create a lack of reliable information often necessary in industrial processes.…”

Section: Introductionmentioning

confidence: 99%

Influence of the organic cation on the formation of hexahalotechnetates: X-ray, thermal and comparative analyses of non-covalent interactions

Novikov,

Zagidullin,

Volkov

et al. 2023

Dalton Trans.

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Technetium(I) carbonyl complexes for nuclear medicine: Coordination-chemical aspect

Cited by 12 publications

References 511 publications

2 + 1 Tricarbonyl Complexes of Technetium(I) with a Combination of N,N-Bidentate Ligands and Ethyl Isocyanoacetate: How Strong Is the Interfering Effect of Chloride Ions on Their Formation?

2 + 1 Tricarbonyl Complexes of Technetium(I) with a Combination of N,N-Bidentate Ligands and Ethyl Isocyanoacetate: How Strong Is the Interfering Effect of Chloride Ions on Their Formation?

DNA‐Targeted Complexes of Tc and Re for Biomedical Applications

Influence of the organic cation on the formation of hexahalotechnetates: X-ray, thermal and comparative analyses of non-covalent interactions

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