Technetium-99m Sulfur-Colloid Cutaneous Lymphoscintigraphy in the Management of Truncal Melanoma

Meyer, C.M.; Lecklitner, Myron L.; Logic, Joseph R.; Balch, C. E.; Bessey, Palmer Q.; Tauxe, W. Newlon

doi:10.1148/131.1.205

Cited by 87 publications

(23 citation statements)

References 4 publications

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“…The results reported here are consistent with the described physical properties of [99mTc]SC (5)(6)(7)(8)(9)13,14,19). This radiopharmaceutical is supplied as a crude mixture of colloids with a range of particle sizes from a few nanometers to over 600 rim.…”

Section: -Osupporting

confidence: 90%

“…The small injection volume was delivered using a 50-/~1 glass syringe (Hamilton, Reno, NV) and a 30-gauge needle. The mice were allowed to recover from anesthesia and run freely in their cages and then killed at each of 10 time points (5,10,15,20,25,45, 60, 90, 120, 240 min) after injection. Upon killing at the designated time point, the FLNs and SLNs were isolated and placed in the center and bottom of 5 ml polystyrene test tubes.…”

Section: Isotope Clearance Studiesmentioning

confidence: 99%

“…This method requires the injection of a radiocolloid that is absorbed into neighboring lymphatics and transported to the SLN where it can be detected by a sterile gamma probe intraoperatively. Radiocolloid-labeled compounds have been used to identify the direction of lymph flow from primary melanomas (4)(5)(6). 99mTechnetium when cou-pled to human serum albumin ([99mTc]HSA) has good imaging properties for lymphatics and lymph nodes and has become a popular choice for lymphoscintigraphy (7)(8)(9)(10).…”

mentioning

confidence: 99%

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Sentinel lymph node uptake of two different technetium-labeled radiocolloids

Anaya

et al. 1997

Annals of Surgical Oncology

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[99mTc]SC is rapidly and efficiently taken up by lymphatics at the primary injection site, is significantly retained in the SLN, and flows slowly to the next echelon node (FLN or ILN) and to the systemic circulation (SP). [99mTc]HSA tends to accumulate less efficiently in the SLN and to disperse more rapidly to the next echelon nodes and to the systemic circulation. By extrapolation, [99mTc]SC is likely to be a better radiocolloid for the intraoperative detection of SLNs.

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Section: -Osupporting

confidence: 90%

Section: Isotope Clearance Studiesmentioning

confidence: 99%

mentioning

confidence: 99%

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Sentinel lymph node uptake of two different technetium-labeled radiocolloids

Anaya

et al. 1997

Annals of Surgical Oncology

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“…[34][35][36] Morton et al 32 described the injection of lymphazurin (vital blue) dye around the primary tumor preoperatively to provide visual clues to the sentinel node and its afferent lymphatic channel. Although this strategy worked in the majority of patients, there were several inherent flaws.…”

Section: Mapping Strategiesmentioning

confidence: 99%

Lymphatic Mapping in Solid Neoplasms: State of the Art

Zervos

Burak

2002

Cancer Control

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“…Lymphoscintigraphy has been in use for decades to map lymph nodes in several tumors including cutaneous malignant melanoma (1,2). The recent application of lymphoscintigraphy to map sentinel nodes draining cutaneous melanoma was patterned after the use of blue dyes.…”

Section: Introductionmentioning

confidence: 99%

Sentinel Node Lymphoscintigraphy in Cutaneous Malignant Melanoma

2002

IJRA

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Until fairly recently radical nodal dissection was the only procedure available to identify and remove micrometastatic foci of nodal spread of malignant melanoma. A less invasive technique, biopsy of the first draining node, the sentinel node, has to been shown to accurately stage lymphatic spread.Identification of the sentinel node is possible using intradermal injection of a blue dye (such as isosulfan blue) and/or radionuclides (sentinel node lymphoscintigraphy). Sentinel node lymphoscintigraphy is advantageous because multiple nodal basins can be "simultaneously" imaged, and the sentinel node can be relatively easily localized with an intraoperative probe.Successful lymphoscintigraphy requires careful injection technique, rapid imaging, and in many cases acquisition of special views to localize nodes. In this article we will discuss the rationale for, the use of, and the methods for performing lymphoscintigraphy.

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Technetium-99m Sulfur-Colloid Cutaneous Lymphoscintigraphy in the Management of Truncal Melanoma

Cited by 87 publications

References 4 publications

Sentinel lymph node uptake of two different technetium-labeled radiocolloids

Sentinel lymph node uptake of two different technetium-labeled radiocolloids

Lymphatic Mapping in Solid Neoplasms: State of the Art

Sentinel Node Lymphoscintigraphy in Cutaneous Malignant Melanoma

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