Technetium-99m – New Production and Processing Strategies to Provide Adequate Levels for SPECT Imaging

Osso, João Alberto; Catanoso, Marcela Forli; Barrio, G.; Brambilla, T. P.; Teodoro, Rodrigo; Dias, Carla Roberta; Suzuki, Kazufumi

doi:10.2174/1874471011205030178

Cited by 14 publications

(10 citation statements)

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“…In the previous study, we have studied the application of spectrophotometric method for determination of NaOCl concentration in Tc generator based on ZBM (Munir, Witarti, & Febriana, 2016 (Osso Jr et al, 2012;Pillai, Dash, Knapp, 2014).…”

Section: Validation Of Simple Uv-vis Spectrophotometry Methods Based Omentioning

confidence: 99%

Validation of Simple Uv-Vis Spectrophotometry Method Based on Ich Q2 (R1) Guideline for the Analysis of Sodium Hypochlorite Using Rhodamine B

2017

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Section: Validation Of Simple Uv-vis Spectrophotometry Methods Based Omentioning

confidence: 99%

Validation of Simple Uv-Vis Spectrophotometry Method Based on Ich Q2 (R1) Guideline for the Analysis of Sodium Hypochlorite Using Rhodamine B

2017

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“…The generator works as follows; a certain volume of the initial solution in the form of sodium (or potassium) molybdate is introduced into the mixing chamber (9) of the lower stage through the central tube (10). The second stage is filled with a washing solution (5 M K 2 CO 3 ) through the tube (11).…”

Section: Two-stage Extraction Centrifugal Semi-countercurrent Generatmentioning

confidence: 99%

“…Since 2007, in the context of the world-wide "Molybdenum crisis" (which was caused by the almost simultaneous shutdown of reactors in Canada and Holland, that providing more than 60% of the world production of 99 Mo), alternative ways of molybdenum-99 production using accelerators took another development [8][9][10]. 99 Mo can be produced by the reaction 100 Mo (p, pn) 99 Mo, as well as 99m Tc directly, with high yields, using the charged particle accelerators (for example see [9]).…”

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confidence: 99%

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2017

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radionuclides, used in medicine as well as in the other fields of science and technology. Mostly, these are elements with different valence state for which selective, well studied and available extraction systems can be found, so that the separation coefficients in those systems are higher than 100. In our opinion, the extraction semi-countercurrent separation method is most suitable for the practical solution of such problems. The essence of this method is that one of the phases (for example, aqueous) is kept in one or several stages not communicating in this phase, while the organic phase (extractant), passes successively through all stages, extracting the extractable components of the mixture of elements in decreasing order of values of the distribution coefficients. The process can also, if necessary, be carried out in inversed form, when the organic phase is stationary and the selective extraction process is carried out by an aqueous solution.The classical semi-countercurrent process and its calculations are well known [1,2]. The semi-counter current extraction process of separation of elements in a dynamic mode was first described in 1951 [3].The main feature of semi-countercurrent separation method is the fact that, if the initial mixture of the components is in the aqueous phase, than the less extractable component can be obtained with any purity level, but the yield continuously decreases. At the same time, the more extracted component has a maximum of the concentration rate equal to the value of the separation coefficient at the beginning of the extraction process.In semi-counter current extractors of the mixer-settler types with gravitational phase separation were used [1][2][3]. The main disadvantages of such devices are high retention volume of the mobile phase, low efficiency and productivity, as well as the possibility of entrainment of the emulsion.Semi-countercurrent processes are used in the separation of similar components in Craig apparatuses, but they are of little use for radiochemical purposes for many reasons: low stratification rate, complex and cumbersome construction, long time needed to achieve equilibrium when the process of mixing is simple wiggle.One of the first papers describing the use of centrifugal semi-countercurrent extractors for the separation of multi-component mixtures requiring a large number of stages was published in 1974 by GV Korpusov et al., [4]. The centrifugal extractor considered is not intended to be used for obtaining individual radionuclide's, since in this case the requirements for the purity of the product are much more stringent at a high recovery rate [4].Considering the need to implement the process of isolation of short-lived isotopes in a short period of time, semi-counter flow extractors with forced phase separation in a centrifugal field were developed. The use of such apparatuses makes it possible to shorten the time of the process and increase the purity of the products, since in this case intensive mixing is acceptable (equilibrium in the extracti...

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“…MBZ memiliki kapasitas serap lebih dari 150 mg Molibdenum/gram MBZ dan saat ini masih terus dikembangkan agar dihasilkan paket teknologi yang bisa diproses lebih lanjut hingga menjadi produk yang siap dimanfaatkan oleh masyarakat [14]. memperoleh radionuklida ini selain melalui fisi 235 U, salah satunya adalah iradiasi MoO3 alam dengan aktivasi neutron [4][5][6][7][8]. Kelebihan 99 Mo hasil aktivasi dibandingkan hasil fisi adalah proses pengolahan yang lebih sederhana, limbah yang dihasilkan lebih sedikit dan tidak digunakannya 235 U. Sedangkan kelemahannya adalah aktivitas jenisnya lebih rendah, yakni Mo sekitar 22,2 -59,2 GBq/g pada saat end of irradiation (EOI) [9], sehingga diperlukan metode yang lebih baik untuk memperoleh 99mTc dalam jumlah yang memadai.…”

Section: Cara Kerjaunclassified

PENGARUH AKTIVITAS 99Mo TERHADAP PROFIL RENDEMEN 99mTc PADA GENERATOR 99Mo/99mTc DENGAN KOLOM MATERIAL BERBASIS ZIRKONIUM (MBZ)

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Technetium-99m – New Production and Processing Strategies to Provide Adequate Levels for SPECT Imaging

Cited by 14 publications

References 0 publications

Validation of Simple Uv-Vis Spectrophotometry Method Based on Ich Q2 (R1) Guideline for the Analysis of Sodium Hypochlorite Using Rhodamine B

Validation of Simple Uv-Vis Spectrophotometry Method Based on Ich Q2 (R1) Guideline for the Analysis of Sodium Hypochlorite Using Rhodamine B

Untitled

PENGARUH AKTIVITAS 99Mo TERHADAP PROFIL RENDEMEN 99mTc PADA GENERATOR 99Mo/99mTc DENGAN KOLOM MATERIAL BERBASIS ZIRKONIUM (MBZ)

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