Technetium-99m methoxyisobutylisonitrile scintigraphy in the assessment of cold thyroid nodules

Riazi, Ahmad; Kalantarhormozi, Mohammadreza; Nabipour, Iraj; Eghbali, Seyed Sajjad; Farzaneh, Mohammad Reza; Javadi, Hamid; Ostovar, Afshin; Seyedabadi, Mohammad; Assadi, Majid

doi:10.1097/mnm.0000000000000013

Cited by 21 publications

(18 citation statements)

References 20 publications

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“…99m Tc-MIBI scintigraphy is a method capable of excluding malignancy of hypofunctional TNs with high accuracy [32], of up to 92.2% [33]. Preinterventional rule out of malignancy on cold nodules was done by both 99m Tc-MIBI scintigraphy and FNAB, as the sufficiency for that task of 99m Tc-MIBI scintigraphy alone is still academically discussed [33].…”

Section: Discussionmentioning

confidence: 99%

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Early assessment of high-intensity focused ultrasound treatment of benign thyroid nodules by scintigraphic means

et al. 2014

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BackgroundHigh-intensity focused ultrasound (HIFU) allows to inflict intracorporal thermal lesions without penetrating the skin or damaging the surrounding tissue. This analysis intends to assess the magnitude of HIFU-induced ablations within benign thyroid nodules using scintigraphic imaging with 99mTc.MethodsTen cold, hot, or indifferent nodules were treated using multiple pulses of HIFU to induce temperatures of around 85°C within the ablation zone. Pre- and posttreatment, uptake values of 99mTc-pertechnetate or 99mTc-MIBI were recorded. The pre-post reduction of nodular uptake was evaluated to assess ablation magnitude.ResultsRelative nodular uptake in relation to total thyroidal uptake decreased after one session of HIFU in all cases. Median 99mTc-MIBI uptake reduction was 35.5% (ranging from 11% to 57%; p < 0.1), while 99mTc-pertechnetate scintigraphy showed a median uptake reduction of 27% (range 10% to 44%; p < 0.1). No major complications were observed.ConclusionsHIFU appears to be safe and is an easy to perform means of thermal ablation. This study shows that HIFU treatment in thyroidal nodules can be evaluated by scintigraphic means shortly after the intervention. Due to small sample size, the exact magnitude of HIFU ablation efficiency in thyroidal nodules remains a value to be assessed in a larger study.

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Section: Discussionmentioning

confidence: 99%

“…Preinterventional rule out of malignancy on cold nodules was done by both 99m Tc-MIBI scintigraphy and FNAB, as the sufficiency for that task of 99m Tc-MIBI scintigraphy alone is still academically discussed [33]. The negative prediction value of combined 99m Tc-MIBI scintigraphy and FNAB is 96.3% [34].…”

Section: Discussionmentioning

confidence: 99%

Early assessment of high-intensity focused ultrasound treatment of benign thyroid nodules by scintigraphic means

et al. 2014

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“…We have observed several cases of discrepancies between FNA cytology and 99m Tc-sestamibi scintigraphy results in our practice, which has evaluated more than 1000 cases to date [3,4] (Fig. 1).…”

Section: Thyroid Nodule Characterization Using Combined Fine-needle Amentioning

confidence: 90%

Thyroid Nodule Characterization Using Combined Fine-Needle Aspiration and ^99mTc-Sestamibi Scintigraphy Strategy

Nabipour

Kalantarhormozi

Assadi

2016

American Journal of Roentgenology

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“…Thus, the specificity and positive predictive value (PPV) of MIBI scan are always quite low in these patient settings 5, 18 . Quantitative analysis of MIBI thyroid scan has proven to increase diagnostic accuracy 21 . Saggiorato 19 first evaluated the tracer Retention Index (R.I.) by using a semi-quantitative method based on the ratio between uptake within the nodule and the normal thyroid tissue uptake.…”

Section: Introductionmentioning

confidence: 99%

Differentiating malignant from benign thyroid nodules with indeterminate cytology by 99mTc-MIBI scan: a new quantitative method for improving diagnostic accuracy

Campennì

Siracusa

Ruggeri

et al. 2017

Sci Rep

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Quantitative 99mTc-MIBI thyroid scintigraphy is a useful tool in differentiating malignant from benign thyroid nodules with indeterminate cytology. The aim of our report is to compare the diagnostic performance of different quantitative methods. We prospectively evaluated 20 patients affected by a thyroid nodule with a cytological diagnosis of class III or IV according to the Bethesda system. Planar images of the thyroid were acquired 10 and 60 minutes after 99mTc-MIBI administration and two different quantitative methods applied (i.e. wash-out index, WOind; retention index, R.I.). All patients underwent lobectomy or thyroidectomy and final histological findings were matched with MIBI results obtained with both quantitative methods. Four out of 20 patients had a final histological result of differentiated thyroid cancer, while benign findings were found in the remaining cases. Overall sensitivity, specificity, accuracy, PPV and NPV were 100% in all for the WOind and 100%, 57.1%, 62.5%, 25% for the R.I., respectively. In conclusion 99mTc-semiquantitative MIBI thyroid scintigraphy with WOind calculation is highly accurate in differential diagnosis of nodules with indeterminate cytology reading.

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Technetium-99m methoxyisobutylisonitrile scintigraphy in the assessment of cold thyroid nodules

Cited by 21 publications

References 20 publications

Early assessment of high-intensity focused ultrasound treatment of benign thyroid nodules by scintigraphic means

Early assessment of high-intensity focused ultrasound treatment of benign thyroid nodules by scintigraphic means

Thyroid Nodule Characterization Using Combined Fine-Needle Aspiration and ^99mTc-Sestamibi Scintigraphy Strategy

Differentiating malignant from benign thyroid nodules with indeterminate cytology by 99mTc-MIBI scan: a new quantitative method for improving diagnostic accuracy

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Technetium-99m methoxyisobutylisonitrile scintigraphy in the assessment of cold thyroid nodules

Cited by 21 publications

References 20 publications

Early assessment of high-intensity focused ultrasound treatment of benign thyroid nodules by scintigraphic means

Early assessment of high-intensity focused ultrasound treatment of benign thyroid nodules by scintigraphic means

Thyroid Nodule Characterization Using Combined Fine-Needle Aspiration and 99mTc-Sestamibi Scintigraphy Strategy

Differentiating malignant from benign thyroid nodules with indeterminate cytology by 99mTc-MIBI scan: a new quantitative method for improving diagnostic accuracy

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Thyroid Nodule Characterization Using Combined Fine-Needle Aspiration and ^99mTc-Sestamibi Scintigraphy Strategy