Technetium-99m-Labeled N-(2-Hydroxypropyl) Methacrylamide Copolymers: Synthesis, Characterization, and in Vivo Biodistribution

Mitra, Amitava; Nan, Anjan; Ghandehari, Hamidreza; Mcneill, Edwina; Mulholland, Justin; Line, Bruce R.

doi:10.1023/b:pham.0000033001.49737.b7

Cited by 47 publications

(38 citation statements)

References 16 publications

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“…Macromolecular drug delivery systems have been modified to take advantage of this characteristic. Positively charged hydroxypropyl methacrylamide (HPMA) polymers [23] and poly(l-lysine) conjugates [24] show greater accumulation in cells than negatively charged polymers. One well-characterized FPE-directed drug delivery system utilizes dextran conjugates to successfully deliver superoxide dismutase in hepatic tissue following modification of saccharides resulting in nonspecific electrostatic interactions with the cell surface [25].…”

Section: Fluid Phasementioning

confidence: 99%

Endocytic mechanisms for targeted drug delivery☆

Bareford

Swaan

2007

Advanced Drug Delivery Reviews

917

712

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Advances in the delivery of targeted drug systems have evolved to enable highly regulated site specific localization to subcellular organelles. Targeting therapeutics to individual intracellular compartments has resulted in benefits to therapies associated with these unique organelles. Endocytosis, a mechanism common to all cells in the body, internalizes macromolecules and retains them in transport vesicles which traffic along the endolysosomal scaffold. An array of vesicular internalization mechanisms exist, therefore understanding the key players specific to each pathway has allowed researchers to bioengineer macromolecular complexes for highly specialized delivery. Membrane specific receptors most frequently enter the cell through endocytosis following the binding of a high affinity ligand. High affinity ligands interact with membrane receptors, internalize in membrane bound vesicles, and traffic through cells in different manners to allow for accumulation in early endosomal fractions or lysosomally associated fractions. Although most drug delivery complexes aim to avoid lysosomal degradation, more recent studies have shown the clinical utility in directed protein delivery to this environment for the enzymatic release of therapeutics. Targeting nanomedicine complexes to the endolysosomal pathway have serious potential for improving drug delivery for the treatment of lysosomal storage diseases, cancer, and Alzheimer's disease. Although several issues remain for receptor specific targeting, current work is investigating a synthetic receptor approach for high affinity binding of targeted macromolecules.

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Section: Fluid Phasementioning

confidence: 99%

Endocytic mechanisms for targeted drug delivery☆

Bareford

Swaan

2007

Advanced Drug Delivery Reviews

917

712

View full text Add to dashboard Cite

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“…HPMA copolymers and drug conjugates have been labeled with various radioactive imaging probes to non-invasively study the effect of size and structure on biodistribution and tumor accumulation in both preclinical and clinical studies with gamma scintigraphy and SPECT (6)(7)(8)(9)(10). Gamma scintigraphy is quantitative and highly sensitive, but is limited by its low spatial resolution.…”

Section: Introductionmentioning

confidence: 99%

Noninvasive Visualization of Pharmacokinetics, Biodistribution and Tumor Targeting of Poly[N-(2-hydroxypropyl)methacrylamide] in Mice Using Contrast Enhanced MRI

Wang

Jeong

et al. 2007

Pharm Res

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“…First, polymeric carriers can increase the water solubility of poorly water-soluble drugs (11). Second, the use of polymeric conjugates can significantly alter drug pharmacokinetics and biodistribution (12,13). This can result in a significant increase in the blood plasma half-life of the drug, which in turn results in an increased total drug exposure.…”

mentioning

confidence: 99%