Technetium-99m-Labeled Autologous Serum Albumin: A Personal-Exclusive Source of Serum Component

Abstract

Technetium-99m human serum albumin (99mTc-HSA) is an important radiopharmaceutical required in nuclear medicine studies. However, the risk of transfusion-transmitted infection remains a major safety concern. Autopreparation of serum component acquired from patient provides a “personal-exclusive” source for radiolabeling. This paper is to evaluate the practicality of on-site elusion and subsequent radiolabeling efficacy for serum albumin. Results showed that the autologous elute contained more albumin fraction than serum without extraction procedure. Good radiochemical purity and stability were demonstrated after radiolabeling. Biodistribution study showed that labeled albumin accumulated immediately in the lung, liver, and kidney. It was cleared steadily and excreted in the urine. The biologic half-life was defined, and all samples passed the pyrogenicity and sterility tests. In conclusion, autoalbumin could be extracted and radiolabeled properly in a nuclear medicine setting. Moreover, the risk of transfusion-transmitted infection associated with nonautologous, multisource 99mTc-HSA agents can be reduced.

Applicability of 99mTc‐Labeled Human Serum Albumin Scintigraphy in Dogs With Protein‐Losing Enteropathy

“…34 Other limitations of the study are the use of control dogs not age, sex, or breed matched to the dogs with PLE. This might have given some few false-positive results considering that specificities of 51-72% are reported in humans when patients with other forms of hypoproteinemia are used as controls.…”

“…33 Finally, in human medicine, 99m Tc-labeled to autologous serum albumin has been used, thus avoiding the production of antibodies and therefore opening the possibility for scintigraphic re-examinations. 34 Other limitations of the study are the use of control dogs not age, sex, or breed matched to the dogs with PLE. This might have given some few false-positive results considering that specificities of 51-72% are reported in humans when patients with other forms of hypoproteinemia are used as controls.…”

“…Species‐specific canine albumin is newly available for therapeutic use and could be used as radiopharmaceutical in the future . Finally, in human medicine, 99m Tc‐labeled to autologous serum albumin has been used, thus avoiding the production of antibodies and therefore opening the possibility for scintigraphic re‐examinations . Other limitations of the study are the use of control dogs not age, sex, or breed matched to the dogs with PLE.…”

Inverse Relationship between Tumor Proliferation Markers and Connexin Expression in a Malignant Cardiac Tumor Originating from Mesenchymal Stem Cell Engineered Tissue in a Rat in vivo Model

“…Moreover several types of MSC may transform to malignant cells in vitro and in vivo (Rubio et al, 2005; Miura et al, 2006; Zhou et al, 2006; Tolar et al, 2007). Due to these contradictory observations, Wong (2011) discussed in her paper the question, whether MSC are “angels or demons.”…”