Technetium-99m generators based on neutron irradiated 12-molybdocerate as column matrix

El-Absy, M. A.; El-Naggar, I.M.; Audah, A. I.

doi:10.1007/bf02038002

Cited by 20 publications

(2 citation statements)

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“…have been examined. 2,[4][5][6][7] Using this approach the content of Mo is about 30 % inside the matrix of the generator and it is possible to use low or medium specific activity 99 Mo produced by neutron activation of 98 Mo (50-500 GBq g -1 ). 2,8 The properties of these generators depend basically upon the preparation conditions of 99 Mo-heteropolymolybdates.…”

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99Mo/99mTc generators performances prepared from zirconium molybate gels

Monroy-Guzman¹,

Díaz-Archundia²,

Hernández-Cortés³

2008

J. Braz. Chem. Soc.

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99m Tc pode ser produzido a partir de géis geradores de molibdato de zircônio contendo 99 Mo/ 99m Tc. Estes géis são parte da matriz geradora e suas características físicas e químicas influenciam diretamente o desempenho do gerador. Neste trabalho, géis molibdato de zircônio foram sintetizados sob diferentes condições e caracterizados por análise termogravimétrica, espectroscopia de infravermelho e análise por ativação neutrônica instrumental (INAA). Nosso objetivo foi investigar e correlacionar o desempenho do gerador com as propriedades físico-químicas do gel. Os dois fatores estudados foram o pH da solução de molibdato e as condições de preparação das soluções do sal de zircônio. Diversas espécies de polimolibdato e zircônio podem ser formadas em solução, as quais podem inibir ou favorecer a formação do gel molibdato de zircônio ou as fases rica em polimolibdato (insolúvel) e de oxi-hidróxido de zircônio. O desempenho do gel gerador 99 Mo/ 99m Tc está diretamente correlacionado com as estruturas do gel. Sistemas mais regulares apresentam desempenho gerador mais baixo se comparados com arranjos mais flexíveis e aleató-rios. As propriedades físico-químicas dos géis, bem como seu comportamento como gerador de tecnécio-99m são apresentados e discutidos. Tc zirconium molybdate gel generators. These gels are part of the generator matrix and their chemical and physical characteristics directly influence the generator performances. In this work zirconium molybdate gels were synthesized under different preparation conditions and characterized by TGA, IR and INAA. Our goal was to investigate and correlate generator performance with the physical-chemical properties of the gel. The two factors studied were the molybdate solution pH and the preparation conditions of the zirconyl salt solutions. Several polymolybdate and zirconium species can be formed in solution which can inhibit or favor the zirconium molybdate gel formation or the insoluble polymolybdate-rich and zirconium oxy-hydroxide phases. The 99 Mo/ 99m Tc gel generator performance is directly correlated with gel structures. More regular network gels present lower generator performances compared to gels with more flexible random framework. The physico-chemical properties of the gels as well as their behavior as technetium-99m generators are presented and discussed.

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99Mo/99mTc generators performances prepared from zirconium molybate gels

Monroy-Guzman¹,

Díaz-Archundia²,

Hernández-Cortés³

2008

J. Braz. Chem. Soc.

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“…El-Absy et al [28] , em 1994, prepararam um gerador pela irradiação do 12-molibdocerato (IV) obtendo 87 % de eficiência de eluição em 10 mL de solução de NaCl 0,9 %. Knapp et al [29] , El-Kolaly et al, em 1996 [32] , desenvolveram um gerador tipo gel, utilizando molibdêniofosfato de zircônio, no qual o 99m Tc pode ser eluído com água destilada ou solução de NaCl 0,9 %.…”

Section: Coluna De Gerador De Gelunclassified

Estudos de técnicas de concentração da atividade de 99mTc eluído de geradores de 99Mo/99mTc tipo gel

Suzuki¹

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On average 80% of the radiopharmaceuticals used in Nuclear Medicine are labeled with 99m Tc due to its physical properties and easy attainment through of 99 Mo/ 99m Tc generators. The Directory of Radiopharmacy (DIRF) of IPEN-CNEN/SP developed a gel type chromatographic generator of MoZr with 99 Mo produced by 98 Mo(n,γ) 99 Mo reaction that occurs at the IEA-R1 Nuclear Reactor. The gel is composed of zirconium molibdate with elution volume of 12 mL with an activity of 11100 MBq (300 mCi) producing a radioactive concentration of 925 MBq (25 mCi)/mL. The fission generator gives a higher radioactive concentration around 1850 MBq (50 mCi)/mL. The aim of this work is to study a system of post-elution concentration of 99m Tc for the attainment of a high enough radioactive concentration to meet the demands of the market, with a proved quality. Two types of systems of post-elution concentration were developed: the single and the tandem. The most appropriate system for the gel generator of 99 Mo/ 99m Tc, being at the same time sterile and vacuum automated, was the tandem system using Dionex 2.5 cc/QMA cartridges. The gel generator is eluted with 10 mL of solution of 0.1% NaCl and the pertechnetate anion is retained in the QMA cartridge and further eluted with 4 mL of saline. The process takes no more than 30 minutes. The elution efficiency of the system of concentration was 90 %. At the beginning of 2009 a global crisis in the supply of 99 Mo took place making it necessary the development of alternative technologies for the production of 99 Mo/ 99m Tc generators using fission produced 99 Mo and the development of an appropriate method to extend the useful life of this generator. The results of this study showed that the same system developed for the post-concentration of the gel generator can be employed for the fission generator, using the tandem system, giving a concentration factor of 3 for the elution of 99m Tc. LISTA DE FIGURAS FIGURA 1 Curva de decaimento e crescimento do gerador de 99 Mo/ 99m Tc

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