Technetium-99m DTPA: A New Radiopharmaceutical for Brain and Kidney Scanning

Hauser, Wolfgang; Atkins, Harold L.; Nelson, K G; Richards, P.

doi:10.1148/94.3.679

Cited by 141 publications

(30 citation statements)

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“…Tc-DTPA is a well-known traditional radiopharmaceutical [23,24]. More than 15 years ago we introduced DTPA orbital SPECT in the clinical management of endocrine patients suffering from László Galuska et al,99m Tc-DTPA retrobulbar SPECT Review GO.…”

Section: Conclusion 99mmentioning

confidence: 99%

The role of 99mTc-DTPA retrobulbar SPECT in staging and follow-up of Graves’ orbitopathy

Galuska

Barna²,

Varga

et al. 2018

Nucl. Med. Rev.

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The pathogenesis of Graves' orbitopathy (GO) is not completely understood. Coexistent hyperfunction of the thyroid gland is frequent; however, GO may also coexist with hypo-or euthyrodism. The course of GO is largely independent of thyroid function, although elevated serum TSH is known to negatively interfere with GO course. GO is severe in 10% of the cases; sight threatening complications may also develop. A successful therapy of GO requires the assesment of both the severity and activity of orbital inflammation. Based on relevant studies and our own experiences, the possible management choices are reviewed here. For this purpose, we compare the clinical value of imaging techniques for detecting the activity of the disease. During the last 15 years, we used 99m Tc-DTPA retrobulbar SPECT routinely in more than 1400 patients to facilitate the right therapeutic decision. This diagnostic utility simplified management decisions compared to previously applied alternative techniques. We recommended the routine use of 99m Tc-DTPA retrobulbar SPECT for the evaluation and follow-up of GO.

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Section: Conclusion 99mmentioning

confidence: 99%

The role of 99mTc-DTPA retrobulbar SPECT in staging and follow-up of Graves’ orbitopathy

Galuska

Barna²,

Varga

et al. 2018

Nucl. Med. Rev.

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“…After the preliminary study published by Hauser (Hauser et al, 1970), the performances of 99 Tc-DTPA clearance was studied from the seventies. Klopper may be considered as one of the pioneers with this markers (Klopper et al, 1972).…”

Section: Clinical Datamentioning

confidence: 99%

How Measuring Glomerular Filtration Rate? Comparison of Reference Methods

Delanaye¹

2012

Basic Nephrology and Acute Kidney Injury

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“…[11]. Following the work of Hauser et al (21) and Strich et al (22), a biphased behavior of the CA distribution within the extracellular space has to be assumed for an appropriate expression of the AIF in the case of a prolonged bolus, as is used in our study protocol. The first phase, occurring during the first five to 12 minutes, mainly consists of mixing of the CA within the extracellular space in the absence of significant renal excretion and the second phase of the AIF is dominated by renal clearance of the CA.…”

Section: Tracer Kinetic Modelmentioning

confidence: 99%

Dynamic T₁ mapping predicts outcome of chemoradiation therapy in primary rectal carcinoma: Sequence implementation and data analysis

Kremser

Trieb

Rudisch

et al. 2007

Magnetic Resonance Imaging

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Purpose:To describe details about the implementation of a dynamic T 1 -mapping technique and a simple data analysis strategy that can be used to predict therapy outcome in primary rectal carcinoma and to investigate the physiologic meaning of the obtained parameter. Materials and Methods:Contrast-enhanced dynamic T 1 mapping was achieved with a snapshot fast low-angle shot (FLASH) T 1 mapping sequence implemented on a 1.5T MR scanner. This method was applied to 58 patients with primary rectal cancer before onset of chemoradiation therapy. A simple data analysis strategy based on the calculation of the maximum slope of the tissue concentration-time curve divided by the maximum of the arterial input function (AIF) was used as a measure of tumor microcirculation (PI values). Results:The snapshot FLASH (SFL) T 1 -mapping technique is accurate and sensitive enough to detect inhomogeneous uptake kinetics within tumor tissue. Classifying the patients into two groups according to therapy response showed lower mean PI values for responders as compared to nonresponders. PI was found to combine information about permeability surface area product (PS) and blood volume. Conclusions:The described method based on dynamic T 1 mapping has the potential to be a clinical tool for predicting therapy outcome of preoperative chemoradiation in patients with primary rectal carcinoma.

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Technetium-99m DTPA: A New Radiopharmaceutical for Brain and Kidney Scanning

Cited by 141 publications

References 0 publications

The role of 99mTc-DTPA retrobulbar SPECT in staging and follow-up of Graves’ orbitopathy

The role of 99mTc-DTPA retrobulbar SPECT in staging and follow-up of Graves’ orbitopathy

How Measuring Glomerular Filtration Rate? Comparison of Reference Methods

Dynamic T₁ mapping predicts outcome of chemoradiation therapy in primary rectal carcinoma: Sequence implementation and data analysis

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Technetium-99m DTPA: A New Radiopharmaceutical for Brain and Kidney Scanning

Cited by 141 publications

References 0 publications

The role of 99mTc-DTPA retrobulbar SPECT in staging and follow-up of Graves’ orbitopathy

The role of 99mTc-DTPA retrobulbar SPECT in staging and follow-up of Graves’ orbitopathy

How Measuring Glomerular Filtration Rate? Comparison of Reference Methods

Dynamic T1 mapping predicts outcome of chemoradiation therapy in primary rectal carcinoma: Sequence implementation and data analysis

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Product

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Dynamic T₁ mapping predicts outcome of chemoradiation therapy in primary rectal carcinoma: Sequence implementation and data analysis