Technetium-99m antibodies labeled with MAG3 and SHNH: An in vitro and animal in vivo comparison

Pulmonary delivery of an erythropoietin Fc fusion protein in non-human primates through an immunoglobulin transport pathway

“…The fraction of the nebulizer dose that was deposited in the lung and the pattern of distribution (central vs. peripheral) of EpoFc in the lung was determined by using our standard method of administration. EpoFc was derivatized with a chelating agent, mercaptoacetyltriglycine (MAG3), by using a standard technique (24) Tc and was administered to monkeys within 1 hr of labeling. Immediately after the aerosol administration, ␥ camera computer images were acquired (with the assistance of Robert Beihn, Scintiprox, Indianapolis) for the posterior and anterior thoracic regions.…”

99mTc Labeling of Highly Potent Small Peptides

“…99m Tc-labeled nonspecific polyclonal IgG's were also used for detection of infection foci (92,94,(172)(173)(174)(175)(176)(177). Although these agents are well-accepted and efficacious, it usually takes 24 h to obtain diagnostically useful images.…”

Solid phase preparations of 99mTc labeled radiopharmaceuticals

“…[7][8][9][10] These yields are also consistently higher than those obtained in methods in which 99m Tc-glucoheptonate is used as a transchelating agent to label peptides using a variety of chelating moieties, 11 and even to label antibodies. 12 Such preparations then require HPLC purification before the agents are used for subsequent evaluation. 13 Because the labeling yields in the present investigation are nearly quantitative, such purification was not necessary.…”