Tear Proteomics Study of Dry Eye Disease: Which Eye Do You Adopt as the Representative Eye for the Study?

Kuo, Ming‐Tse; Fang, Po-Chiung; Kuo, Shu-Fang; Chen, Alexander; Huang, Yu‐Ting

doi:10.3390/ijms22010422

Cited by 11 publications

(12 citation statements)

References 37 publications

(18 reference statements)

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“…Kuo et al mentioned in their recently published research that bilateral eyes of DED patients may have similar but different ocular surface performance and tear composition [28]. Similar to the research of other authors in our study results, we included the first examined eye because automatic measurement may produce distorted measurements and results from the second examined eye [28,30].…”

Section: Discussionmentioning

confidence: 75%

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The Influence of Work Environment Factors on the Ocular Surface in a One-Year Follow-Up Prospective Clinical Study

et al. 2021

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The purpose of this study was to assess the effect of environmental working conditions on the symptoms and signs of dry eye disease and to examine whether and how those conditions impact the ocular surface. Methods: This single-center, prospective clinical study with a 1-year follow-up included 150 patients. The following parameters were evaluated: non-invasive keratograph break-up time (NIKBUT), tear meniscus height (TMH), and conjunctival and limbal hyperemia. We also performed staining of the surface of the eye for simulated fluorescein images, Schirmer’s test I, assessment of Meibomian gland dysfunction (MGD), and an Ocular Surface Disease Index (OSDI) questionnaire. Results: In the OW (office workers) group, in people working > 4 h at the computer, the NIKBUT before work and the Schirmer test results were statistically significantly lower than in people working <4 h. The conjunctival hyperemia result before work was statistically significantly higher for people working >4 h at a computer in both groups and after work in the MW (medical workers) group. Low relative air humidity in the building and air-conditioned rooms negatively affects the tear film, causing the symptoms of dry eye disease. At the 1-year follow-up, there was a statistically significant reduction in conjunctival and limbal hyperemia in the OW group as well as a statistically significant reduction in TMH at the first examination before and after work, and in the second examination after 1 year in both groups. Conclusions: Environmental factors such as reduced relative air humidity, increased air temperature, and decreased illumination have a negative impact on the ocular surface.

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Section: Discussionmentioning

confidence: 75%

“…There were no statistically significant differences between the eyes. The automatic measurement may produce distorted results for the other eye; therefore, in our results we included only the first eye examined [28].…”

Section: Examinationsmentioning

confidence: 99%

The Influence of Work Environment Factors on the Ocular Surface in a One-Year Follow-Up Prospective Clinical Study

et al. 2021

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“…It was recommended to evaluate the biochemical features of tears in DED from the more severe eye [ 49 ]. Also, the more severe eye may reflect the ocular discomfort better.…”

Section: Discussionmentioning

confidence: 99%

Different Number of Sessions of Intense Pulsed Light and Meibomian Gland Expression Combination Therapy for Meibomian Gland Dysfunction

Lee

Kim

Lee

et al. 2022

Korean J Ophthalmol

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Purpose: To evaluate the effect of the intense pulsed light (IPL) and meibomian gland expression (MGX) combination therapy according to the different numbers of sessions in the meibomian gland dysfunction (MGD).Methods: Ninety patients with MGD were included. Patients had a maximum of 1 to 5 sessions of IPL (AQUA CEL, Jeisys, Korea) and MGX combination therapy at 2-week intervals. At each visit, the ocular surface disease index (OSDI) questionnaire score, MG profile grades, tear matrix metalloproteinase (MMP)-9 grades, tear break-up time (BUT), tear osmolarity, tear secretion and corneal erosions were evaluated. Results:The number of patients who had a total of 1 to 5 consecutive sessions (1S to 5S) was 10, 25, 17, 20, and 18, respectively. The time-serial decrease of OSDI scores was significant in patients who had a total of 3 or more sessions (P=0.002 [3S] and P<0.001 [4S and 5S]). The MG expressibility grade decreased with a total of 2 or more sessions (P<0.001 [2S to 5S]), but the meibum quality significantly improved with all sessions (P=0.012 [1S], P=0.024 [2S], P=0.015 [3S], and P<0.001 [4S and 5S]).Although tear BUT increased even in patients with 1 session (P=0.040 [1S], P=0.005 [3S], P=0.006[4S], and P=0.021 [5S]), tear MMP-9, osmolarity, Schirmer I, and corneal erosions were not improved in every number of sessions. The female gender was the sole contributor to the final symptomatic improvement (P=0.042), and the MGD stages were not related to the final decrease in OSDI score. Conclusions:The OSDI score, MGD grades, and BUT were improved after the IPL and MGX combination therapy in MGD patients. Unlike MGD grades and tear film instability might be improved just after a few sessions, the overall subjective relief was accomplished in a total of 3 or more sessions.

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“…Hence, DED has been considered a disease of multifactorial etiology, and is correlated to the presence of certain comorbidities in systemic organs 7 . DED etiology and pathology findings have indicated that patients with different DED etiologies may present with different signs and symptoms 8 . It has been reported that patients who smoke or have comorbidities experience more severe symptoms of DED, when compared to patients in a control group 9 .…”

Section: Background and Summarymentioning

confidence: 99%

A literature-derived dataset on risk factors for dry eye disease

Yang

Pan

et al. 2023

Sci Data

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Dry eye disease (DED) is a common disease associated with disorder of tear secretion. Research on risk factors for DED, such as depression, arthritis, thyroid disease, stroke and diabetes, is important to facilitate its diagnosis and prognosis. We created a dataset on risk factors for DED (DrDED) with public access that can provide up-to-date and validated data acquired from systematically searched and screened, high-quality studies. The established DrDED contained 119 studies published between 2000 and 2022. The range of the study sample size was from 43 to 4,871,504. The study types were, as follows: cross-sectional (n = 92), retrospective cohort (n = 9), prospective cohort (n = 10), and case-control (n = 8) studies. Data from eligible studies were collected and presented for the present study, including the publication information, study characteristics, definition and prevalence of the disease, and risk factors for DED, together with the strength of association. With the publication of new relevant studies, the DrDED will be updated, and the data will be made accessible to the users. Design Type(s) Dataset creation objective Measurement Type(s) Patient outcome • scientific publication • risk factors • dry eye disease Technology Type(s) Digital curation • documenting • meta-analysis Factor Type(s) Depression • arthritis • thyroid disease • stroke disease • diabetes Sample Characteristic(s) Homo sapiens • dry eye disease • global

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Tear Proteomics Study of Dry Eye Disease: Which Eye Do You Adopt as the Representative Eye for the Study?

Cited by 11 publications

References 37 publications

The Influence of Work Environment Factors on the Ocular Surface in a One-Year Follow-Up Prospective Clinical Study

The Influence of Work Environment Factors on the Ocular Surface in a One-Year Follow-Up Prospective Clinical Study

Different Number of Sessions of Intense Pulsed Light and Meibomian Gland Expression Combination Therapy for Meibomian Gland Dysfunction

A literature-derived dataset on risk factors for dry eye disease

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