Tear levels of IL-7, IL-1α, and IL-1β may differentiate between IgG4-related disease and Sjögren’s syndrome

Martín‐Nares, Eduardo; Hernández-Molina, Gabriela; Lima, Guadalupe; Hernández‐Ramírez, Diego F.; Chan-Campos, Isela; Saavedra‐González, Vanessa; Llórente, Luis

doi:10.1007/s10067-023-06501-2

Cited by 6 publications

(4 citation statements)

References 21 publications

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“…262,266 IL-7 was detectable in tears from both IgG4-related disease and SS patients, however levels in SS patients did not appear to differ from healthy controls. [224][225][226] IL-7 and IL-15 protein levels were also higher in urine from patients with active lupus nephritis compared to inactive systemic lupus erythematosus, other chronic kidney diseases and healthy controls. 223 Do fibroblasts provide these growth factors in IMID to support the observed increases in lymphocytes?…”

Section: Rationing Of Growth Factorsmentioning

confidence: 90%

“…223 G-CSF was detectable in tears from both IgG4-related disease and SS patients, however levels in SS patients did not appear to differ from healthy controls. [224][225][226] Data on growth factor levels in local fluid and biopsy samples in FD is scarcer than for IMID. What is available shows a trend towards increased GMand G-CSF in some patients, which was positively correlated with neutrophils in these samples.…”

Section: Rationing Of Growth Factorsmentioning

confidence: 99%

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Distinct fibroblast functions associated with fibrotic and immune-mediated inflammatory diseases and their implications for therapeutic development

M. S. Barron,

Fabre,

2024

F1000Res

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Fibroblasts are ubiquitous cells that can adopt many functional states. As tissue-resident sentinels, they respond to acute damage signals and shape the earliest events in fibrotic and immune-mediated inflammatory diseases. Upon sensing an insult, fibroblasts produce chemokines and growth factors to organize and support the response. Depending on the size and composition of the resulting infiltrate, these activated fibroblasts may also begin to contract or relax thus changing local stiffness within the tissue. These early events likely contribute to the divergent clinical manifestations of fibrotic and immune-mediated inflammatory diseases. Further, distinct changes to the cellular composition and signaling dialogue in these diseases drive progressive fibroblasts specialization. In fibrotic diseases, fibroblasts support the survival, activation and differentiation of myeloid cells, granulocytes and innate lymphocytes, and produce most of the pathogenic extracellular matrix proteins. Whereas, in immune-mediated inflammatory diseases, sequential accumulation of dendritic cells, T cells and B cells programs fibroblasts to support local, destructive adaptive immune responses. Fibroblast specialization has clear implications for the development of effective induction and maintenance therapies for patients with these clinically distinct diseases.

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Section: Rationing Of Growth Factorsmentioning

confidence: 90%

Section: Rationing Of Growth Factorsmentioning

confidence: 99%

Distinct fibroblast functions associated with fibrotic and immune-mediated inflammatory diseases and their implications for therapeutic development

M. S. Barron,

Fabre,

2024

F1000Res

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“…Some of these cytokines and chemokines are also associated with objective eye dryness tests or ocular symptoms. 34 The beginning and progression of SS are heavily influenced by innate and adaptive immunity, with each phase involving a number of steps that ultimately lead to the onset and persistence of the disease. 35,36 A high-fat diet (HFD), stress, infection, hypoxia, and other factors can cause epithelial cells to become damaged in people who are vulnerable.…”

Section: The Pathology Of the Lacrimal Gland In Ssmentioning

confidence: 99%

“…These cytokines can cause lacrimal gland necrosis and apoptosis through oxidative stress, impairing secretory function or decreasing tear production. Some of these cytokines and chemokines are also associated with objective eye dryness tests or ocular symptoms 34 …”

Section: Introductionmentioning

confidence: 99%

Advances in imaging of the lacrimal gland in Sjögren's syndrome: A narrative review

Zhong,

Zhang,

Ran

2023

J of Clinical Ultrasound

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Due to lymphocytic infiltration of the salivary and lacrimal glands, Sjogren's syndrome (SS), a systemic autoimmune illness that mostly affects the exocrine glands, causes dry mouth (xerostomia) and dry eyes (xerophthalmia). Additionally, SS is associated with various comorbidities such as cardiovascular diseases, infections, musculoskeletal diseases, and cancers. Among patients with SS, xerophthalmia frequently arises as a complication, leading to insufficient tear production or rapid tear evaporation, thereby causing discomfort, irritation, and a gritty sensation in the eyes. This article aims to examine recent advancements in the imaging of the lacrimal gland in Sjögren's syndrome and briefly discusses the utilization of various imaging examinations for the lacrimal gland in this particular disease.

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Inflammatory cytokines and their potential role in Sjogren’s syndrome risk: insights from a mendelian randomization study

Shi,

Xu,

Zhang

et al. 2024

Adv Rheumatol

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Aim This study aimed to investigate the causal impact of inflammatory cytokines on Sjogren’s Syndrome (SS) and to identify potential biomarkers for SS clinical management using Mendelian Randomization (MR). Materials and methods Leveraging GWAS summary data of inflammatory cytokines and SS, we executed the first two-sample MR analysis. Genetic variants from prior GWASs associated with circulating inflammatory cytokines served as instrumental variables (IVs). Data regarding cytokines were analyzed using the Olink Target-96 Inflammation panel, synthesizing data from 14,824 participants. GWAS summary statistics for SS were procured from the UK Biobank, focusing on samples of European ancestry. To discern the causal relationship between inflammatory cytokines and SS, several MR methodologies, including inverse variance weighted (IVW) and MR-Egger regression, were applied. Results After rigorous IV quality control, 91 cytokines were incorporated into the MR analysis. The IVW analysis identified 8 cytokines with a positive association to SS: Axin-1 (OR 2.56, 95% CI 1.07–6.10), T-cell surface glycoprotein CD5 (OR 1.81, 95% CI 1.08–3.02), CUDP1 (OR 1.61, 95% CI 1.00-2.58), CXCL10 (OR 1.92, 95% CI 1.25–2.95), IL-4 (OR 2.18, 95% CI 1.22–3.91), IL-7 (OR 2.35, 95% CI 1.27–4.33), MCP-2 (OR 1.27, 95% CI 1.05–1.54), and TNFRSF9 (OR 1.83, 95% CI 1.03–3.24), suggesting their potential in increasing SS risk. Conclusion Our study conducted through MR, identified various inflammatory cytokines associated with SS risk, validating some previous research results and offering some new potential biomarkers for SS. However, these findings necessitate further research for validation and exploration of their precise role in the onset and progression of SS.

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Tear levels of IL-7, IL-1α, and IL-1β may differentiate between IgG4-related disease and Sjögren’s syndrome

Cited by 6 publications

References 21 publications

Distinct fibroblast functions associated with fibrotic and immune-mediated inflammatory diseases and their implications for therapeutic development

Distinct fibroblast functions associated with fibrotic and immune-mediated inflammatory diseases and their implications for therapeutic development

Advances in imaging of the lacrimal gland in Sjögren's syndrome: A narrative review

Inflammatory cytokines and their potential role in Sjogren’s syndrome risk: insights from a mendelian randomization study

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