Tear cytokine and ocular surface alterations following brief passive cigarette smoke exposure

Rummenie, Van Tuan; Matsumoto, Yukihiro; Doğru, Murat; Wang, Yan; Hu, Yue; Ward, Samantha K.; Igarashi, A.; Wakamatsu, Tais Hitomi; Ibrahim, Osama; Goto, Eiki; Luyten, Gré P.M.; Inoue, Hiroko; Saito, Ichiro; Shimazaki, Jun; Tsubota, Kazuo

doi:10.1016/j.cyto.2008.05.011

Cited by 86 publications

(69 citation statements)

References 59 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Urinary levels of DiY did not differ between smokers and non-smokers, while plasma NY studies have presented conflicting results (32)(33)(34). Increased HEL concentration was detected in the tears of subject following passive exposure to cigarette smoke in healthy non-smokers compared with non-exposed subjects (35). No statistically significant association of HEL, NY and DiY levels with smoking status was identified in the present study.…”

Section: Discussioncontrasting

confidence: 47%

See 1 more Smart Citation

Lipid-lysine adducts and modified tyrosines as markers of oxidative stress in the second trimester of pregnancy and their association with infant characteristics

Rejc

Kato

Karas-Kuzelicki

et al. 2016

Experimental and Therapeutic Medicine

View full text Add to dashboard Cite

Abstract. Pregnancy is a physiological state accompanied by excessive levels of oxidative stress (OS), due to the increased demand and utilisation of oxygen. There is increasing evidence that maternally augmented OS exerts an adverse effect on pregnancy outcome. The aim of the present prospective study was to determine the association between the urinary concentration of relatively novel OS markers measured in the second trimester of pregnancy and the infant characteristics at birth. The maternal levels of urinary hexanoyl-lysine (HEL), propanoyl-lysine (PRL), dityrosine (DiY) and 3-nitrotyrosine (NY) were evaluated in generally healthy pregnant subjects to determine their association with birth weight, gestation at delivery and Apgar score. The observed levels of the markers were in agreement with those measured in healthy non-pregnant subjects in a previous study. A positive correlation was detected between HEL and PRL, as well as between HEL and DiY. Although the absence of a correlation between NY and the other markers has been previously noted in a non-pregnant population, a positive correlation in the pair PRL-NY (r=0.367; P<0.001) was observed in the present study. Maternal cigarette smoking was associated with increased urinary PRL levels (P=0.034). The most notable observation in the present study was that high levels of PRL and NY were associated with low Apgar scores at 1 and 5 min after birth (OR, 1.098 and 2.084 for PRL and NY, respectively; P<0.05). However, poor predictive accuracy was shown. For NY, the following results were obtained: Area under the curve (AUC), 0.818; sensitivity, 100%; specificity, 57%; positive predictive value (PPV), 11.54%; and negative predictive value (NPV), 100%.For PLR the values were as follows: AUC, 0.802; sensitivity, 100%; specificity, 62.6%; PPV, 13.05%; and NPV, 100%. DiY was negatively associated with preterm birth risk (OR=0.703; P=0.028). In conclusion, the results of the present study indicated the presence of OS in the second trimester of pregnancy, which was detected with damage to lipids and proteins and associated with an adverse Apgar score; however, the selected urinary markers exhibited poor positive predictive efficacy.

show abstract

Section: Discussioncontrasting

confidence: 47%

“…Increased levels of oxidative damage were expected to be associated with ageing and maternal weight, on the basis of previously reported associations (34)(35)(36)(37)(38)(39). However, no correlation was detected between maternal age and the levels of HEL, DiY and NY.…”

Section: Discussionmentioning

confidence: 96%

Lipid-lysine adducts and modified tyrosines as markers of oxidative stress in the second trimester of pregnancy and their association with infant characteristics

Rejc

Kato

Karas-Kuzelicki

et al. 2016

Experimental and Therapeutic Medicine

View full text Add to dashboard Cite

show abstract

“…The smokers are increasing in developing countries as in Pakistan especially among women and children [53]. Two thirds of blindness cases in the world is reported in women [3], as women stay most of the time at home in Pakistan, smoking will lead to health problems in infants and children due to passive smoking [54,55].…”

Section: Discussionmentioning

confidence: 99%

On-Set of Cataract and Accumulation of Copper, Lead and Cadmium in Smokers of Karachi, Pakistan

Ahmad¹

2014

J Environ Anal Toxicol

View full text Add to dashboard Cite

“…Smoking also affects tear secretion and protein components in tears [5,6]. Furthermore, cigarette smoking may be harmful to the corneal endothelium.…”

Section: Introductionmentioning

confidence: 99%

Untitled

2015

AOVS

View full text Add to dashboard Cite

We compared the biomechanical properties of corneas in eyes of healthy chronic smokers and non-smokers. In this prospective, comparative, and cross-sectional study, 50 eyes of 50 healthy chronic smokers (Study group) and 50 eyes of 50 agematched, healthy non-smokers (Control group) were enrolled. The corneal hysteresis (CH) and corneal resistance factor (CRF) were measured intwo groups using the Ocular Response Analyzer (ORA). Differences in the corneal biomechanical properties were determined using an independent-samples t test. Urine samples were collected to measure urinary levels of cotinine. Correlations between the number of cigarettes smoked per day, smoking duration, age, and CH-CRF values in the smokers group were also evaluated. Mean CH was 10.63±2.08 (SD) mmHg and 10.57±1.45 mmHg and the mean CRF was 10.53±1.81 mmHg and 10.27±1.77 mmHg in the smoker and control groups, respectively (p>0.05). CH and CRF were not correlated with the number of cigarettes smoked per day, smoking duration, or age. The findings indicate that cigarette smoking does not affect corneal biomechanical parameters such as CH and CRF. In addition, CH and CRF are not affected by the number of cigarettes smoked per day, smoking duration, or age. Keywords 2/4 Results and Discussion Demographic FindingsIn this study, 50 eyes of 50 healthy chronic smokers admitted to our department were included. As a control group, 50 eyes of 50 age-matched, healthy non-smokers were included. The mean ± SD age of the included subjects was 36.28±5.91 years (range 28-48) and 35.02±5.83 years (range 27-49 years) for the smokers group and the non-smokers group, respectively (p ˃0.05). On average, smokers smoked 16.70±8.00 (range 10-30) cigarettes per day and had been smoking for 12.20±3.01 (range 10-20) years.). The characteristics of the two groups of subjects are shown in (Table 1). There were no statistically significant differences between the two groups with regard to gender, AL, and CCT distributions (p˃0.05).Cotinine levels in the urine were 44.2±9.8 ng/ml in nonsmokers and 2439±451 ng/ml in smokers (p˂0.05). These data clearly indicate that the smokers were accurately selected, because the urine cotinine concentration in nonsmokers is normally below 500 ng/ml [14]. Biomechanical Parameters (CH and CRF) Urinary Cotinine ConcentrationTo distinguish objectively between smokers and nonsmokers, it was necessary to determine the level of cotinine in the urine. Cotinine, the major metabolite of nicotine, has a half life of 24 hours and is readily detectable in the smoker's urine even several days after the smoker has terminated smoking. Urine samples were collected in clean plastic containers to measure urinary levels of cotinine [11], and the basic technique used was based on spectrophotometric assessment at wavelength 532 nm. Laboratory workups were performed in the laboratory of the Kanuni Sultan Suleyman Education and Research Hospital. The influence of diuresis on urinary cotinine concentrations was corrected using the method described by T...

show abstract

Tear cytokine and ocular surface alterations following brief passive cigarette smoke exposure

Cited by 86 publications

References 59 publications

Lipid-lysine adducts and modified tyrosines as markers of oxidative stress in the second trimester of pregnancy and their association with infant characteristics

Lipid-lysine adducts and modified tyrosines as markers of oxidative stress in the second trimester of pregnancy and their association with infant characteristics

On-Set of Cataract and Accumulation of Copper, Lead and Cadmium in Smokers of Karachi, Pakistan

Untitled

Contact Info

Product

Resources

About