Tear and serum soluble leukocyte activation markers in conjunctival allergic diseases

Leonardi, Andrea; Borghesan, Franco; Faggian, Diego; Depaoli, M; Secchi, Antonio; Plebani, Mario

doi:10.1016/s0002-9394(99)00295-0

Cited by 106 publications

(75 citation statements)

References 24 publications

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“…Outros autores acreditam que a maioria dos pacientes com CCP tem algum outro tipo de alergia (17)(18) . Na Itália, encontraram 40% dos pacientes com primaveril apresentando outra forma de alergia associada (19) . Em série retrospectiva publicada, 41,5% dos pacientes com CCP tinham doença sistêmica atópica e 48,7% tinham antecedente de alergia na família (20) .…”

Section: Discussionunclassified

Aspectos clínicos e epidemiológicos da conjuntivite alérgica em serviço de referência

Marback¹,

Freitas²,

Paranhos³

et al. 2007

Arq. Bras. Oftalmol.

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Section: Discussionunclassified

Aspectos clínicos e epidemiológicos da conjuntivite alérgica em serviço de referência

Marback¹,

Freitas²,

Paranhos³

et al. 2007

Arq. Bras. Oftalmol.

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“…8 Increased levels of activated blood eosinophils and serum eosinophil cationic protein have been detected, indicating a systemic involvement. 9,10 A role for basic fibroblast growth factor (b-FGF) and transforming growth factor ␤ has been suggested, 11 as well as for nerve growth factor and neuropeptide substance P (s-P). 12,13 Despite a high prevalence of immunoglobulin E (IgE)-sensitized patients (ϳ50%), the causes of the disease remain obscure.…”

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confidence: 99%

Long Eyelashes in a Case Series of 93 Children With Vernal Keratoconjunctivitis

et al. 2005

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ABSTRACT. Objective. Vernal keratoconjunctivitis (VKC) is a chronic conjunctivitis that affects children mainly in temperate areas, with exacerbations in spring and summer. Eyelashes provide natural protection for the eyes from sunshine, wind, and foreign bodies. These factors induce a worsening of signs and symptoms in VKC, whereas mechanical protection of the eyes produces relief. The aim of this study was to evaluate eyelash length in a large series of VKC patients and in ageand gender-matched healthy subjects.Methods. Upper eyelash length was measured in 93 VKC patients (mean age: 8.7 years; range: 4 -18 years) with a digital caliper. History, clinical form, type of presentation, degree of severity, and drug therapy were evaluated. Skin tests and serum-specific immunoglobulin E for common allergens, serum-total immunoglobulin E, peripheral blood eosinophil counts, and serum eosinophil cationic protein were determined. Two age-and gender-matched control subjects for each VKC patient underwent the same eyelash measurement.Results. The upper eyelashes were significantly longer in VKC patients than in control subjects (mean ؎ SD: 8.9 ؎ 1.17 mm vs 7.9 ؎ 1.07 mm). In healthy subjects, a negative correlation was found between eyelash length and age. With multivariate analysis, unlike control subjects, the eyelash length in VKC patients did not correlate with age, was positively correlated with the degree of severity of VKC, and was negatively correlated with the use of topical cyclosporine.Conclusions. Patients with VKC had longer eyelashes than healthy matched subjects. ABBREVIATIONS. VKC, vernal keratoconjunctivitis; bFGF, basic fibroblast growth factor; s-P, substance P; IgE, immunoglobulin E; s-ECP, serum eosinophil cationic protein; PBEC, peripheral blood eosinophil count.

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“…In the past 20 years, histamine tear levels have been measured using first a radioisotope assay (16)(17)(18)(19) and, more recently, using immunoenzymatic-or radioimmunoassays (20)(21)(22)(23) (Table 3). It has been difficult to document increased histamine concentrations in tears of allergic subjects compared to normal subjects or other inflammtory ocular diseases.…”

Section: Tear Histamine Levelsmentioning

confidence: 99%

“…The measurement may be more accurate if histaminase enzymes are first destroyed by immediate perchloric acid treatment of the samples (13,(21)(22)(23). With this procedure, greater levels of tear histamine have been shown, not only in the early phase but also in the late phase of the allergic reaction induced by allergen challenge (22).…”

Section: Tear Histamine Levelsmentioning

confidence: 99%

“…With this procedure, greater levels of tear histamine have been shown, not only in the early phase but also in the late phase of the allergic reaction induced by allergen challenge (22). Presently histamine titration in tears is used in conjunction with the conjunctival provocation test for the assessment of mast cell inhibitory properties of topical drugs (23).…”

Section: Tear Histamine Levelsmentioning

confidence: 99%

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Role of Histamine in Allergic Conjunctivitis

Leonardi

2000

Acta Ophthalmologica Scandinavica

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ABSTRACT. Histamine remains the main mediator released by both specific allergic and non-specific mast cell activation. Histamine is the classic mediator of itching, flare and redness. The effects of histamine in allergic conjunctivitis are mediated by H 1 -receptor activation on blood vessels and nociceptive nerves. Histamine effects may be prolonged and exaggerated since a defect in the histaminase enzymes has been recently demonstrated in VKC. The effects of histamine on conjunctival tissues may be more complex than those manifested by the simple symptom of itching. In fact, proinflammatory effects of histamine on conjunctival epithelial cells and fibroblasts have been demonstrated. Preliminary results showed that the H 1 antagonist, emedastine, reduces significantly cytokine production from histamine-stimulated fibroblasts.

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Tear and serum soluble leukocyte activation markers in conjunctival allergic diseases

Cited by 106 publications

References 24 publications

Aspectos clínicos e epidemiológicos da conjuntivite alérgica em serviço de referência

Aspectos clínicos e epidemiológicos da conjuntivite alérgica em serviço de referência

Long Eyelashes in a Case Series of 93 Children With Vernal Keratoconjunctivitis

Role of Histamine in Allergic Conjunctivitis

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