The main interest of this study was to evaluate the degree of association that the use of ICT could have to school performance in mathematics, within a limited geographical area. The data was obtained thanks to the International Student Assessment Program (PISA). 1376 students from the Canary Islands participated. To obtain the best possible approximation to the phenomenon, a mixed research method was used, in which a linear hierarchical model (HLM) analysis was used to assess the characteristics of students and schools. The results reflected positive changes in school performance influenced by the effective use of ICT. It was shown that learning can be enhanced thanks to ICT, unless its use is not appropriate.