OBE concept is the mainstream trend of the development of higher education in the new era. To change the traditional teaching method of Mechanical Design Basis for a long time, This paper carries out a mixed curriculum teaching reform based on OBE concept, establishes a teaching mode guided by ability training, with "online independent learning" & "offline flipping" & "process assessment" & "ability assessment" as the main line, fully mobilize students' time in the second classroom and give full play to the advantages of group cooperative learning, and adopt diversified assessment forms. Uses information platform software to connect the three stages before, during and after class, Through the implementation of PAD teaching and cooperative learning, students can truly become the center of the classroom. Creates corresponding teaching situations, explore "differentiated teaching". Through the integration of course teaching, scientific research and discipline competition, remarkable teaching achievements have been achieved, and the purpose of teaching reform has been achieved.