Evidence‐based practice is a multistep process of incorporating empirical evidence, clinical expertise, and patient values to make clinical decisions. In the United States, there are legal mandates (i.e., No Child Left Behind [Public Law 107‐110], Individuals with Disabilities Education Act [Public Law 108‐446]) requiring the use of scientifically based practices. Insurance companies in the United States are increasingly requiring all treatments that provide reimbursement to be evidence‐based, including coverage of treatment of autism spectrum disorders. There is also growing (and possibly greater) recognition of the importance of providing evidence‐based practices globally. Hence, there is a great need to identify which treatments for individuals with autism spectrum disorders are evidence‐based. This chapter is devoted to providing an overview of the current state of the science related to evidence‐based psychosocial interventions (both comprehensive and focal in nature), and concludes with an overview of essential curricular components for treatment programs for individuals who have autism spectrum disorders.