Teaching cells to dance: the impact of transistor miniaturization on the manipulation of populations of living cells

Abonnenc, Mélanie; Altomare, Luigi; Baruffa, M.; Ferrarini, Valentina; Guerrieri, R.; Iafelice, Bruno; Leonardi, A.; Manaresi, Nicolò; Medoro, Gianni; Romani, Annalisa; Tartagni, Marco; Vulto, Paul

doi:10.1016/j.sse.2004.10.015

Cited by 6 publications

(3 citation statements)

References 18 publications

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“…Several strategies commonly used in research have been summarized in a review by (Desai et al 2007). They include the use of electric fields and dielectrophoresis (Abonnenc et al 2005;Leu et al 2005), optical trapping (Chiou et al 2005;Nahmias et al 2005), mechanical control through MEMSbased (Thielecke et al 2005) or local pressure approaches (Jeong and Konishi 2009), and the use of mixed methods (Lettieri et al 2003;Shackman et al 2007). It is well known that all common technologies have a strong impact both on the particles and on the surrounding medium, hence limiting the applicability of these techniques.…”

Section: Introductionmentioning

confidence: 99%

3D visualization of convection patterns in lab-on-chip with open microfluidic outlet

Gazzola

Scarselli

Guerrieri

2009

Microfluid Nanofluid

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Open-outlet microfluidics is getting more and more attention, thanks to the generation of capillarity-driven flows which simplify the connection with the macroworld. It is known that convection flows are generated at the interface with air, i.e., the meniscus. Several works have investigated evaporation-induced convection, but its effect on particle position control in open-outlet biodevices is still not characterized. In this paper, we present the results of 3D measurement of particle traces near the meniscus in an open-outlet vertical 400 lm micro-channel filled with a water-based saline solution. Using a standard optical microscope and a system of mirrors, we observe the 3D position of individual micro-beads floating in the solution, in a way akin to particle image velocimetry technique. A single vortex is generated at the meniscus and occupies the whole region under observation at a distance of 1.5-2.7 mm from the meniscus. The generation of the convection pattern and the vortex rotational speed are described. The convection patterns disappear when evaporation is inhibited, while both the vortex generation and the rotational speed are faster for highly saline solutions. These results are relevant to the design of biochips which require control of the particle position in a fluid since they emphasize that in open-outlet microfluidic systems not only the gravitational fall but also the convection drag must be counteracted.

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Section: Introductionmentioning

confidence: 99%

3D visualization of convection patterns in lab-on-chip with open microfluidic outlet

Gazzola

Scarselli

Guerrieri

2009

Microfluid Nanofluid

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“…The alliance between microelectronic integrated circuits (ICs) and living biology leads the way into the design and development of cutting-edge bio-sensing devices and smart lab-on-chips [1]- [4]. ICs can directly interact and interface with the biological world, thus the final spatial resolution can be strongly enhanced [5].…”

Section: Introduction and State Of The Artmentioning

confidence: 99%

“…The overall sensitivity is also increased as a consequence of the noise reduction. In fact, such devices allows to create read-out circuits directly underneath the sensing electrodes with no need of cables connection to an external instrumentation [1]. Fig.…”

Section: Introduction and State Of The Artmentioning

confidence: 99%

Low-power architecture for integrated CMOS bio-sensing

Ros

Miccoli

Sanginario

et al. 2017

2017 IEEE Biomedical Circuits and Systems Conference (BioCAS)

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Integrated CMOS bio-sensing aims to design and to develop complete lab-on-chip systems. Distributed wireless sensors, at the micrometer scale, can be directly interfaced with the surrounding biological environment. In this scenario, the major challenges to be faced are devices size, power consumption, and an effective communication/system overall architecture.We propose therefore a complete and effective sensors/system architecture (data acquisition, encoding, and transmission), along with examples and results from preliminary works. The system leverages on an event-based (quasi-digital) paradigm, where analog information is mapped onto the timings of digital addressevents, so to improve the communication robustness while retaining the full information content.

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Biosphere

Maghear

Săndulescu

2014

Environmental Analysis by Electrochemical Sensors and Biosensors

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Teaching cells to dance: the impact of transistor miniaturization on the manipulation of populations of living cells

Cited by 6 publications

References 18 publications

3D visualization of convection patterns in lab-on-chip with open microfluidic outlet

3D visualization of convection patterns in lab-on-chip with open microfluidic outlet

Low-power architecture for integrated CMOS bio-sensing

Biosphere

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