Teaching an Old Drug a New Trick: Targeting Treatment Resistance in Genitourinary Cancers
Karina Aguilar,
Anuj K. Sharma,
Tianyu Yang
et al.
Abstract:In the quest for improving the clinical outcome of patients with metastatic genitourinary cancers, including metastatic renal cell carcinoma (mRCC), the emphasis often is on finding new targeted therapies. However, two studies by Jordan et al. (Oncogenesis 2020) and Wang et al. (Cancer Cell Int 2022) demonstrate the feasibility of improving the efficacy of a modestly effective drug Sorafenib against mRCC by attacking a mechanism hijacked by RCC cells for inactivating Sorafenib. The studies also identified hyal… Show more
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