Online education is an inevitable trend in the era of digital transformation, but effective implementation is not easy. This research was conducted to understand the relationship between interaction and the perceived progress of online learning, under the mediated effect of satisfaction. Data was gathered from 223 full-time learners at nine universities in Vietnam, using Google Forms. Since the study had a mediating variable, the partial least squares structural equation modeling (PLS-SEM) method was used. The results show that learner–lecturer interaction, learner–learner interaction, and learning content have positive impacts on online learning satisfaction. The findings of this study reveal that satisfaction has a positive influence on overall progress, which means that, as satisfaction increases, perceived progress in online learning interaction increases as well. Based on the findings, the authors suggest using the flipped classroom model to increase the interactivity and effectiveness of online teaching. This study sheds new light on the relationship between interactions and perception of progress in online education at private universities in Vietnam's southern region.