Tea saponins as natural stabilizers for the production of hesperidin nanosuspensions

Long, Jiaying; Song, Jung Soo; Zhang, Xumin; Deng, Mao; Xie, Long; Zhang, Linlin; Li, Xiaofang

doi:10.1016/j.ijpharm.2020.119406

Cited by 45 publications

(26 citation statements)

References 44 publications

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“…Although paths for those roles are not well-understood and despite differences in chemical structures, different activities exist for TPS, including adjuvant (136), antibacterial (137,138), antidiabetic (139), antifungal (140-142), anti-inflammatory (123,125), antioxidative (109,143), antiprotozoal (144)(145)(146), antiproliferative (147), antiviral (148,149), cardiotonic and cardioprotective (122), and cytotoxic (127,128,150) effects have been reported. Additionally, TPS have also exhibited other functional properties, such as food-additive in flavorings (26), gastroprotective (151,152), hemolytic (153), hepatic (139,149), immunologic (123,154), insecticide (155,156), anti-obesity therapeutic potential (111,116,157,158), neuroprotective (159), vermicide (160), and emulsifier and stabilizer of the nanosuspensions (161,162).…”

Section: Terpenes Biosynthesis and Functionalitymentioning

confidence: 99%

“…In summary, although over the last years, review research advances in TPS have been evident (27,162,(202)(203)(204)(205)(206)(207)(208), the disparities in physicochemical characteristics of close and non-closely intermediate related compounds in TPS-containing plants (209-211) from one to another material depends on the vast structural diversity of TPS molecules (131,212). Therefore, feasible investigations should focus on TPS physio-metabolic interactions after ingestion to elucidate complex interactions with the diet's nutritive value and substantial variation in gastrointestinal microflora and animal metabolisms.…”

Section: Future Perspectivesmentioning

confidence: 99%

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Nutritional Aspects of Ecologically Relevant Phytochemicals in Ruminant Production

Tedeschi

Muir²,

Naumann

et al. 2021

Front. Vet. Sci.

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This review provides an update of ecologically relevant phytochemicals for ruminant production, focusing on their contribution to advancing nutrition. Phytochemicals embody a broad spectrum of chemical components that influence resource competence and biological advantage in determining plant species' distribution and density in different ecosystems. These natural compounds also often act as plant defensive chemicals against predatorial microbes, insects, and herbivores. They may modulate or exacerbate microbial transactions in the gastrointestinal tract and physiological responses in ruminant microbiomes. To harness their production-enhancing characteristics, phytochemicals have been actively researched as feed additives to manipulate ruminal fermentation and establish other phytochemoprophylactic (prevent animal diseases) and phytochemotherapeutic (treat animal diseases) roles. However, phytochemical-host interactions, the exact mechanism of action, and their effects require more profound elucidation to provide definitive recommendations for ruminant production. The majority of phytochemicals of nutritional and pharmacological interest are typically classified as flavonoids (9%), terpenoids (55%), and alkaloids (36%). Within flavonoids, polyphenolics (e.g., hydrolyzable and condensed tannins) have many benefits to ruminants, including reducing methane (CH4) emission, gastrointestinal nematode parasitism, and ruminal proteolysis. Within terpenoids, saponins and essential oils also mitigate CH4 emission, but triterpenoid saponins have rich biochemical structures with many clinical benefits in humans. The anti-methanogenic property in ruminants is variable because of the simultaneous targeting of several physiological pathways. This may explain saponin-containing forages' relative safety for long-term use and describe associated molecular interactions on all ruminant metabolism phases. Alkaloids are N-containing compounds with vast pharmacological properties currently used to treat humans, but their phytochemical usage as feed additives in ruminants has yet to be exploited as they may act as ghost compounds alongside other phytochemicals of known importance. We discussed strategic recommendations for phytochemicals to support sustainable ruminant production, such as replacements for antibiotics and anthelmintics. Topics that merit further examination are discussed and include the role of fresh forages vis-à-vis processed feeds in confined ruminant operations. Applications and benefits of phytochemicals to humankind are yet to be fully understood or utilized. Scientific explorations have provided promising results, pending thorough vetting before primetime use, such that academic and commercial interests in the technology are fully adopted.

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Section: Terpenes Biosynthesis and Functionalitymentioning

confidence: 99%

Section: Future Perspectivesmentioning

confidence: 99%

Nutritional Aspects of Ecologically Relevant Phytochemicals in Ruminant Production

Tedeschi

Muir²,

Naumann

et al. 2021

Front. Vet. Sci.

View full text Add to dashboard Cite

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“…In the last few years, some studies have been published about hesperidin nanoparticles. Among the produced nanoparticles containing hesperidin are polysaccharide [15,16], nanocrystals [17], inorganic nanoparticles [18][19][20] nanoemulsions [21][22][23], liposomes [24], solid lipid nanoparticles [25], nanosuspensions [26], magnetic [27] and protein nanoparticles [11].…”

Section: Introductionmentioning

confidence: 99%

Optimized Chitosan-Coated Gliadin Nanoparticles Improved the Hesperidin Cytotoxicity over Tumor Cells

Filho

Machado

Diedrich

et al. 2021

Braz. arch. biol. technol.

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Hesperidin is a natural compound which is found in citric fruits and presents antitumor and antimicrobial activities. However, the in vivo efficacy of Hesperidin is reduced due to its low oral bioavailability. Protein-based nanoparticles have been applied to improve biological parameters of drugs and natural compounds. Gliadin is a monomeric protein present in wheat. In this study, gliadin-based nanoparticles containing hesperidin were obtained by desolvation technique and a Taguchi orthogonal array design was employed to optimize the formulation. The independent variables were set as concentration of CaCl2 (0.5; 1 or 2%) and stabilizing agent (Pluronic F68, Tween 80 or sodium caseinate). The dependent variables consisted of mean diameter, polydispersity index, zeta potential, and encapsulation efficiency. The results showed significant effects on the dependent variables when 1% CaCl2 and Pluronic F68 were used. The optimized formulation was coated with chitosan to increase the physical stability of the nanoparticles. The final nanoparticles presented a mean diameter of 321 nm and polydispersity index of 0.217, and spherical shape. After coating, the Zeta potential was +21 mV, and the encapsulation efficiency was 73 %. The in vitro release assay showed that about 98% of the drug was released from the nanoparticles after 48 h. Moreover, HIGHLIGHTS A Taguchi design optimized the development of hesperidin-loaded gliadin nanoparticles. A chitosan-coating was added to improve the physical stability of nanoparticles. Nanoparticles reduced the hesperidin cytotoxicity over healthy Vero cells. Nanoparticles improved the hesperidin cytotoxicity over tumor cells.

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“…Ma, et al [22] fabricated zein/TS nanoparticles that act as the vehicle of lutein, which showed great stability, excellent redispersibility, and high bioaccessibility. Long, et al [23] evaluated the ability of TS to form and stabilize nanosuspensions and investigated the feasibility of TS as a cryoprotectant of hesperidin solid nanocrystals. Yuan, et al [24] produced the pH-driven binary composite nanoparticles based on zein and TS without any organic reagents and high-energy equipment.…”

Section: Introductionmentioning

confidence: 99%

Formation and Physical Stability of Zanthoxylum bungeanum Essential Oil Based Nanoemulsions Co-Stabilized with Tea Saponin and Synthetic Surfactant

et al. 2021

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The purpose of this work was to evaluate the possibility of adding tea saponin (TS) to reduce the synthetic surfactant concentration, and maintain or improve the shelf stability of nanoemulsions. The Zanthoxylum bungeanum essential oil (2.5 wt%) loaded oil-in-water nanoemulsions were co-stabilized by Tween 40 (0.5–2.5 wt%) and TS (0.1–5 wt%). A combination of several analytical techniques, such as dynamic laser scattering, interfacial tension, zeta potential, and transmission electron microscope, were used for the characterization of nanoemulsions. Low levels of TS (0.1–0.5 wt%) with Tween 40 had significant effects on the emulsification, and a nanoemulsion with the smallest droplet diameter of 89.63 ± 0.67 nm was obtained. However, in the presence of high TS concentration (0.5–5 wt%), micelles generated by the non-adsorbed surfactants in the aqueous lead to droplets growth. In addition, the combinations of Tween 40 and TS at the high level (>3.5 wt%) exerted a synergistic effect on stabilizing the nanoemulsions and preventing both Ostwald ripening and coalescence. The negative charged TS endowed the droplets with electrostatic repulsion and steric hinderance appeared to prevent flocculation and coalescence. These results would provide a potential application of natural TS in the preparation and stabilization of nanoemulsions containing essential oil.

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Tea saponins as natural stabilizers for the production of hesperidin nanosuspensions

Cited by 45 publications

References 44 publications

Nutritional Aspects of Ecologically Relevant Phytochemicals in Ruminant Production

Nutritional Aspects of Ecologically Relevant Phytochemicals in Ruminant Production

Optimized Chitosan-Coated Gliadin Nanoparticles Improved the Hesperidin Cytotoxicity over Tumor Cells

Formation and Physical Stability of Zanthoxylum bungeanum Essential Oil Based Nanoemulsions Co-Stabilized with Tea Saponin and Synthetic Surfactant

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