Tea polyphenols improve lipid metabolism in hybrid grouper (♀ Epinephelus fuscoguttatus × ♂ E. lanceolatu) fed high-lipid diets

Pan, Simiao; Yan, Xiaobo; Li, Tao; Suo, Xiangxiang; Líu, Hao; Tan, Beiping; Zhang, Shuang; Li, Zhihao; Yang, Yefeng; Zhang, Haitao; Dong, Xiaohui

doi:10.1016/j.aqrep.2022.101217

Cited by 9 publications

(9 citation statements)

References 60 publications

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“…From the data, we reasoned that LCP in the food increased lipolysis (LPL, HL) and inhibited lipid synthesis (FAS, ACC), which resulted in the rate of lipolysis being larger than the rate of lipid synthesis and, hence, decreased lipid deposition in the body composition. This is consistent with the results of a number of earlier studies [ 16 ].…”

Section: Discussionsupporting

confidence: 94%

“…It has been shown that feeding HLD leads to increased serum TC, TG, and LDL levels and decreased HDL levels [ 31 , 41 ]. The variations in HDL and LDL revealed the problem of lipid metabolism [ 16 ]. HDL transfers cholesterol from extrahepatic tissue to the liver for processing in the form of HDL-C. LDL transfers endogenous cholesterol to extrahepatic tissue in the form of LDL cholesterol.…”

Section: Discussionmentioning

confidence: 99%

“…To explore the mechanism of lipid metabolism in hybrid grouper, we analyzed the expression of some of the important liver genes involved in lipid metabolism (lipolysis: pparα , lpl ; lipogenesis: fas ) with reference to previous studies [ 16 ]. It is reported that LCP can improve lipid metabolism in rats [ 60 ].…”

Section: Discussionmentioning

confidence: 99%

“…Under the conditions of incubation at 95°C for 30 s, 95°C for 5 s, and 60°C for 34 s, the gene expression level of each sample was detected by the RT-qPCR method, and the threshold cycle (Ct value) was collected. The 2 − ΔΔ Ct method is used to calculate the relative expression level of the target gene [ 16 , 29 ].…”

Section: Methodsmentioning

confidence: 99%

“…However, most studies have shown that high levels of lipid intake can lead to abnormal accumulation of lipids in various tissues of the fish body and cause damage to the fish liver, thus affecting the health of the fish [ 13 , 14 ]. In fish, the primary harm of fatty liver included degeneration and necrosis of hepatic cells and a decrease in stress resistance [ 15 , 16 ]. Thus, it is important to identify meaningful strategies to mitigate the adverse impacts of HLD.…”

Section: Introductionmentioning

confidence: 99%

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Lycopene Alleviates the Adverse Effects of Feeding High-Lipid Diets to Hybrid Grouper (♀Epinephelus fuscoguttatus ×♂E. lanceolatus)

Zhou,

Liu,

et al. 2023

Aquaculture Nutrition

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It has been found that high-lipid diets (HLDs) disrupt lipid metabolism in fish, leading to an excessive accumulation of lipids in various tissues of the fish body. The objective of this study was to investigate if the inclusion of lycopene (LCP) in an HLD may mitigate the adverse consequences of excessive dietary lipid intake in hybrid grouper (♀ Epinephelus fuscoguttatus × ♂ E. lanceolatus). The experimental design incorporated a control group (L0), which was administered a diet consisting of 42% protein and 16% lipid. The diets for groups L1, L2, and L3 were developed by augmenting the control diet with 100, 200, and 400 mg/kg LCP, respectively. The duration of the trial spanned a period of 42 days. The results of the study showed that the weight gain rate (WGR) and protein efficiency ratio (PER) of the three LCP treatment groups (L1, L2, and L3) tended to increase and then decrease, with a significant increase in WGR and PER in L2 ( P < 0.05 ). Visceral somatic index and hepatic somatic index tended to decrease and then increase in all treatment groups, with a significant decrease in L2 ( P < 0.05 ). In serum dietary LCP significantly reduced triglyceride (TG), total cholesterol (TC), and low-density lipoprotein (LDL) content and significantly increased high-density lipoprotein (HDL) content ( P < 0.05 ). In the liver, dietary LCP reduced TC, TG, and very LDL levels and improved lipoprotein lipase, hepatic lipase, fatty acid (FA) synthetase, and acetyl-CoA carboxylase activities. The number and area of hepatic lipid droplets decreased significantly with increasing LCP content. In the liver, the addition of appropriate levels of LCP significantly upregulated lipoprotein lipase (lpl) and peroxisome proliferator-activated receptor α (pparα). In summary, dietary LCP improves growth and reduces lipid deposition in the liver of hybrid grouper by increasing lipolytic metabolism and decreasing FA synthesis. Under the experimental conditions, the fitted curve analysis showed that the recommended LCP additions to the high lipid diet for juvenile hybrid grouper were 200–300 mg/kg.

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Section: Discussionsupporting

confidence: 94%

Section: Discussionmentioning

confidence: 99%