Tea, hormone‐related cancers and endogenous hormone levels

Wu, Anna H.; Yu, Mimi C.

doi:10.1002/mnfr.200500142

Cited by 49 publications

(41 citation statements)

References 69 publications

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“…A possible mechanism for green tea consumption to reduce breast cancer risk is through the modulation of estrogen levels (Wu and Yu, 2006). Plasma estrone levels were significantly lower in regular green tea drinkers than in non-or irregular green tea drinkers.…”

Section: Human Studiesmentioning

confidence: 96%

“…In fact, most of the recent publications on the protective effect of tea against cancer were based on studies in Shanghai and the neighboring province of Zhejiang in China, where green tea is usually consumed. The proposed association between green tea consumption and lowered risk of prostate and ovarian cancer (reviewed in (Wu and Yu, 2006)) are intriguing and worth further investigation. Even with the same population consuming the same type of tea, the picture is still not clear.…”

Section: Human Studiesmentioning

confidence: 99%

“…Finally, we will discuss the relevance of these results in the prevention of human cancer based on human epidemiological and interventions studies. This topic has been covered by previous reviews (Yang and Wang, 1993;Bushman, 1998;Yang et al, 2002;Hou et al, 2004;Lambert et al, 2005;Clark and You, 2006;Khan et al, 2006;Lu et al, 2006b;Sun et al, 2006b;Sun et al, 2006a;Wu and Yu, 2006;Yang et al, 2006a;Yang et al, 2006b). Because of the citation limitations, we will cite the key reviews instead of some of the original articles.…”

Section: Introductionmentioning

confidence: 99%

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Tea and cancer prevention: Molecular mechanisms and human relevance

Yang

Lambert

et al. 2007

Toxicology and Applied Pharmacology

236

169

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Tea made from the leaves of the plant Camellia sinensis is a popular beverage. The possible cancer preventive activity of tea and tea polyphenols has been studied extensively. This article briefly reviews studies in animal models, cell lines, and possible relevance of these studies to the prevention of human cancer. The cancer preventive activity of tea constituents have been demonstrated in many animal models including cancer of the skin, lung, oral cavity, esophagus, stomach, liver, pancreas, small intestine, colon, bladder, prostate, and mammary gland. The major active constituents are polyphenols, of which (-)-epigallocatechin-3-gallate (EGCG) is most abundant, most active, and most studied, and caffeine. The molecular mechanisms of the cancer preventive action, however, are just beginning to be understood. Studies in cell lines led to the proposal of many mechanisms on the action of EGCG. However, mechanisms based on studies with very high concentrations of EGCG may not be relevant to cancer prevention in vivo. The autooxidation of EGCG in cell culture may also produce activities that do not occur in many internal organs. In contrast to the cancer prevention activity demonstrated in different animal models, no such conclusion can be convincingly drawn from epidemiological studies on tea consumption and human cancers. Even though the human data are inconclusive, tea constituents may still be used for the prevention of cancer at selected organ sites if sufficient concentrations of the agent can be delivered to these organs. Some interesting examples in this area are discussed.

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Section: Human Studiesmentioning

confidence: 96%

Section: Human Studiesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Tea and cancer prevention: Molecular mechanisms and human relevance

Yang

Lambert

et al. 2007

Toxicology and Applied Pharmacology

236

169

View full text Add to dashboard Cite

show abstract

“…By contrast, one epidemiological study (Sun et al, 2006) indicated that black tea drinking appears to be unrelated to breast cancer risk. Wu and Yu (2006) have suggested that the preventive effect of green tea against breast cancer may be related to the decreased blood estrogen levels found in green tea drinkers, while increased levels of this hormone were found in black tea drinkers. Leong et al (2008) used the C3(1)/SV40 mouse model to evaluate the chemopreventive effects of green tea on human breast cancer, which showed that the administration of 0.5% polyphenol in drinking water significantly suppressed the development of tumor growth by 40% compared to tap water-fed animals.…”

Section: Prevention Of Cancermentioning

confidence: 99%

Tea and human health: biomedical functions of tea active components and current issues

Chen

Zhi

2015

J. Zhejiang Univ. Sci. B

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Originating in China, tea and tea planting have spread throughout the world since the middle of the Tang dynasty. Now people from 160 countries in the world are accustomed to tea drinking. A brief history of tea's medicinal role in China and its spread to the world are introduced. The effectiveness of tea active components and tea drinking on major human diseases, including cancer, metabolic syndrome, cardiovascular disease, and neurodegenerative diseases, is discussed. Also presented are some related issues, such as the bioavailability of tea active components, the new formulations of tea polyphenols, and the safety for consumers of dietary supplements containing tea polyphenols.

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“…The polyphenols a large group of plant chemicals that includes the catechins,are thought to be responsible for the health benefits that have traditionally been attributed to tea, especially green tea (17).The active components of tea responsible for such biological activities are now recognized to be catechins (also known as polyphenols) (18).Major catechins are epicatechin gallate (ECG), epicatechin (EC) ,epigallocatechin (EGC) ,and epigallocatechingallate(EGCG).The most active and abundant catechin in green tea is epicallocatechin -3-gallate (EGCG) (19).…”

Section: Introductionmentioning

confidence: 99%