Tea consumption and its interactions with tobacco smoking and alcohol drinking on oral cancer in southeast China

Chen, Fa; Bc, He; Lv, Yan; Fp, Liu; Jf, Huang; Zj, Hu; Zhang, Lin; Xy, Zheng; Ls, Lin; Zhang, Zuo‐Feng; Cai, Le

doi:10.1038/ejcn.2016.208

Cited by 31 publications

(31 citation statements)

References 22 publications

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“…Although there was limited evidence to explain this finding, a recent study indicated that concentration of serum Cu was higher in smokers than nonsmokers (Memon et al, ). It is well established that tobacco smoking is a major risk factor for oral cancer (Chen et al, ). Previous studies demonstrated that smoking inhibited the production of antioxidant enzymes and induced oxidative stress (Gupta, Khanduja, & Sharma, ).…”

Section: Discussionmentioning

confidence: 99%

Serum copper and zinc levels and the risk of oral cancer: A new insight based on large‐scale case–control study

et al. 2018

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Section: Discussionmentioning

confidence: 99%

Serum copper and zinc levels and the risk of oral cancer: A new insight based on large‐scale case–control study

et al. 2018

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“…Oral cancer, the most common cancer in head and neck, is a growing public health problem in many parts of the world especially for developing countries . Our previous epidemiological studies have suggested that environmental factors such as cigarette smoking, alcohol drinking, tea consumption, dietary factors, oral hygiene, and HPV infection were associated with the risk of oral cancer . However, despite exposure to the same environmental factors, only a few individuals develop oral cancer, indicating that genetic factors also play a critical role in oral cancer.…”

Section: Introductionmentioning

confidence: 99%

A functional haplotype of NFKB1 influence susceptibility to oral cancer: a population‐based and in vitro study

et al. 2018

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Genetic variations of NF‐κB and its inhibitor IκB genes and their biological mechanism in oral cancer were not well recognized. The purpose of this study was to evaluate the associations of polymorphisms in NFKB1 and NFKBIA with oral cancer susceptibility, and further explore their potential mechanism in vitro. First, the polymorphisms of NFKB1 and NFKBIA were genotyped through iPLEX Sequenom MassARRAY platform in a case–control study with 425 oral cancer patients and 485 healthy controls. Then, the function was explored by a luciferase reporter assay and an electrophoretic mobility shift assay (EMSA) in human tongue squamous cell carcinoma cell lines. The results indicated that NFKB1 rs28362491 Del/Del and rs72696119 G/G genotypes were associated with the risk of oral cancer, with a strong linkage disequilibrium (D′ = 0.991, r 2 = 0.971). Moreover, DG haplotype of NFKB1 also showed a significant increased risk (OR = 1.25, 95% CI: 1.02–1.53, P = 0.030). Dual‐luciferase reporter assays further revealed that the plasmids with DG or IG or DC haplotype transfected with Tca‐8113 cells or CAL‐27 cells had a lower luciferase expression than that with IC haplotype. EMSA demonstrated that 4‐bp ATTG deletion in the promoter of NFKB1 abolished the binding site of transcription factor. Our preliminary findings suggest that the haplotype of rs28362491 and rs72696119 in NFKB1 could act as a novel genetic marker to predict oral cancer risk in the southeast of China, but much more extensive researches still need to be conducted.

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“…2 The few studies assessing the additive interaction for tobacco and alcohol conducted their analysis in individual HNSCC subsites and reported super-additive interactions of varying degrees. [27][28][29] Oral Hr-HPV infections were significantly associated with HNSCC, regardless of Hr-HPV genotype. A study conducted in Canada did not find any significant association with HNSCC and Hr-HPV types excluding HPV16.…”

Section: Discussionmentioning

confidence: 97%

Joint effect of tobacco, alcohol, and oral HPV infection on head and neck cancer risk in the French West Indies

et al. 2020

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We investigated the role of tobacco and alcohol consumption on the occurrence of head and neck squamous cell carcinomas (HNSCC), and the joint effects of these factors with oral human papillomavirus (HPV) infection in the French West Indies, in the Caribbean. We conducted a population‐based case‐control study (145 cases and 405 controls). We used logistic regression models to estimate adjusted odds ratios (OR) and their 95% confidence intervals (CI). Two‐way interactions were assessed on both multiplicative and additive scales. Current smoking (OR = 11.6, 95% CI = 6.7‐20.1), drinking more than five glasses of alcohol per day (OR = 2.7, 95% CI = 1.2‐4.7), and oral infection with High‐risk HPV (OR = 2.4, 95% CI = 1.1‐5.0) were significantly associated with HNSCC. The combined exposure to tobacco and alcohol produced a significant synergistic effect on the incidence of HNSCC. Oral infection with High‐risk HPV increased the risk of HNSCC in never smokers and nondrinkers. The effects of tobacco, alcohol, and of the combined exposure of tobacco and alcohol were substantially lower in HPV‐positive than in HPV‐negative HNSCC. This is the first case‐control study to investigate the role of tobacco smoking, alcohol drinking and oral HPV infection in an Afro‐Caribbean population. Although each of these risk factors has a significant effect, our findings indicate that tobacco and alcohol play a less important role in Hr‐HPV‐positive HNSCC. Further investigations are warranted notably on the interaction of these three risk factors by cancer site.

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Tea consumption and its interactions with tobacco smoking and alcohol drinking on oral cancer in southeast China

Abstract: Tea consumption protects against oral cancer in non-smokers or non-alcohol drinkers, but this effect may be obscured in smokers or alcohol drinkers. Additionally, demographics may modify the association between tea consumption and oral cancer.

Cited by 31 publications

References 22 publications

Serum copper and zinc levels and the risk of oral cancer: A new insight based on large‐scale case–control study

Serum copper and zinc levels and the risk of oral cancer: A new insight based on large‐scale case–control study

A functional haplotype of NFKB1 influence susceptibility to oral cancer: a population‐based and in vitro study

Joint effect of tobacco, alcohol, and oral HPV infection on head and neck cancer risk in the French West Indies

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