TDP43 proteinopathy exhibits disease, tissue, and context-specific cryptic splicing signatures
Dwight F Newton,
Rena Yang,
Johnny Gutierrez
et al.
Abstract:Mislocalization of the nuclear protein TAR DNA-binding protein 43 (TDP43) is a hallmark of ALS and FTD which leads to de-repression and inclusion of cryptic exons. These cryptic exons represent promising biomarkers of TDP43 pathology in a spectrum of neurodegenerative diseases. However, most cryptic exons to date have been identified from in vitro models or a single cortical FTD dataset, limiting our understanding of tissue and cell-specific splices as well as differences between in vitro and in vivo processes… Show more
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