Abstract:Leishmania donovani, a unicellular protozoan parasite, causes a wide range of human diseases including fatal visceral leishmaniasis. Tyrosyl DNA‐phosphodiesterase 1 (TDP1) hydrolyzes the phosphodiester bond between DNA 3′‐end and a tyrosyl moiety of trapped topoisomerase I‐DNA covalent complexes (Top1cc). We have previously shown Leishmania harbors a TDP1 gene (LdTDP1), however, the biological role of TDP1 remains largely unknown. In the present study, we have generated TDP1 knockout L. donovani (LdTDP1−/−) pr… Show more
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