TDCS modulates cortical excitability in patients with disorders of consciousness

Abstract

Transcranial direct current stimulation (tDCS)1 has been reported to be a promising technique for consciousness improvement for patients with disorders of consciousness (DOC).2 However, there has been no direct electrophysiological evidence to demonstrate the efficacy of tDCS on patients with DOC. Therefore, we aim to measure the cortical excitability changes induced by tDCS in patients with DOC, to find electrophysiological evidence supporting the therapeutic efficacy of tDCS on patients with DOC. In this study, we enrolled sixteen patients with DOC, including nine vegetative state (VS)3 and seven minimally conscious state (MCS)4 (six females and ten males). TMS-EEG was applied to assess cortical excitability changes after twenty minutes of anodal tDCS of the left dorsolateral prefrontal cortex. Global cerebral excitability were calculated to quantify cortical excitability in the temporal domain: four time intervals (0–100, 100–200, 200–300, 300-400 ms). Then local cerebral excitability in the significantly altered time windows were investigated (frontal, left/right hemispheres, central, and posterior). Compared to baseline and sham stimulation, we found that global cerebral excitability increased in early time windows (0–100 and 100-200 ms) for patients with MCS; for the patients with VS, global cerebral excitability increased in the 0-100 ms interval but decreased in the 300-400 ms interval. The local cerebral excitability was significantly different between MCS and VS. The results indicated that tDCS can effectively modulate the cortical excitability of patients with DOC; and the changes in excitability in temporal and spatial domains are different between patients with MCS and those with VS.

Theta network centrality correlates with tDCS response in disorders of consciousness

“…Notably, similar spectral shifts and behavioral improvements have been reported with pharmacological agents like Zolpidem [6]. As with Zolpidem, tDCS could have a direct effect on cortical activity, initiating activation of chronically underactive brain regions, as previously shown [7]. This hypothesis is supported by previous tDCS studies showing an increased cortical oscillation activity in the theta and alpha bands in healthy volunteers following anodal DLPFC tDCS [8,9].…”

The clinical outcome of concurrent speech therapy and transcranial direct current stimulation in dysarthria and palilalia following traumatic brain injury: A case study

“…According to his report, it seems that part of this improvement has been due to increased levels of participant`s consciousness. This finding is consistent with studies investigated the effect of tDCS on the level of consciousness in normal people (Lauro et al, 2014) and patients with abnormal levels of consciousness (Zhang et al, 2017, Bai et al, 2017. The reduction of speech rate and decreasing palilalia were other goals of this study.…”

Combined behavioral and electrophysiological evidence for a direct cortical effect of prefrontal tDCS on disorders of consciousness

“…Yet, very few studies have investigated the electrophysiological effects of tDCS in DoC patients. Some studies focused on differentiating tDCS impact based on the patients' state of consciousness (50,51). Others used a qualitative analysis of the EEG background activity to characterize tDCS response (24).…”