Abstract:Background and Purpose: Isoleucine is a branched-chain amino acid
serving as an essential nutrient resource and metabolic. However, its
role in cerebral ischemic stroke remains unknown. Experimental Approach:
Middle cerebral artery occlusion (MCAO) was used to mimic in vivo model
of stroke. Oxygen-glucose deprivation insult (OGD) was used to injure
cultured cortical neurons. High-Performance Liquid Chromatography (HPLC)
was used to measure the level of isoleucine. A western blot assay and
immunofluorescent sta… Show more
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