TCTP is a critical survival factor that protects cancer cells from oxidative stress-induced cell-death

Lucibello, Maria; Gambacurta, Alessandra; Zonfrillo, Manuela; Pierimarchi, Pasquale; Serafino, Annalucia; Rasi, Guido; Rubartelli, Anna; Garaci, Enrico

doi:10.1016/j.yexcr.2011.07.012

Cited by 48 publications

(50 citation statements)

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“…Three kinds of drugs (DHA, sertraline and thioridazine) were reported as the direct anti-cancer drug targets for TCTP. Fujita et al demonstrated that DHA could bind to human TCTP and decrease its cellular level through promoting ubiquitination and proteasomedependent degradation (Fujita et al, 2008;Lucibello et al, 2011).…”

Section: Discussionmentioning

confidence: 99%

Targeted Efficacy of Dihydroartemisinin for Translationally Controlled Protein Expression in a Lung Cancer Model

Liu

Wu²,

Guo³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Objective: Lung cancer is one of the malignant tumors with greatest morbidity and mortality around the world. The keys to targeted therapy are discovery of lung cancer biomarkers to facilitate improvement of survival and quality of life for the patients with lung cancer. Translationally controlled tumor protein (TCTP) is one of the most overexpressed proteins in human lung cancer cells by comparison to the normal cells, suggesting that it might be a good biomarker for lung cancer. Materials and Methods: In the present study, the targeted efficacy of dihydroartemisinin (DHA) on TCTP expression in the A549 lung cancer cell model was explored. Results and Conclusions: DHA could inhibit A549 lung cancer cell proliferation, and simultaneously up-regulate the expression of TCTP mRNA, but down-regulate its protein expression in A549 cells. In addition, it promoted TCTP protein secretion. Therefore, TCTP might be used as a potential biomarker and therapeutic target for non-small cell lung cancers.

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Section: Discussionmentioning

confidence: 99%

Targeted Efficacy of Dihydroartemisinin for Translationally Controlled Protein Expression in a Lung Cancer Model

Liu

Wu²,

Guo³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…They observed that TCTP is up-regulated in these cells under mild oxidative stress, whereas strong oxidative stress resulted in reduced TCTP levels and subsequent apoptotic cell death. Increased TCTP levels partially protected cells from oxidation-induced cell death (Lucibello et al 2011). Similarly, overexpression of TCTP (TMA19) in yeast conferred resistance to arsenite to the cells (Takahashi et al 2010).…”

Section: Involvement In Cellular Stress Responsesmentioning

confidence: 99%

“…the antagonism of TCTP to the tumour suppressor protein p53, which is crucial for TCTP to exert its cancer-promoting activity (Amson et al 2012;Chen et al 2011). The cytoprotective role of TCTP in cancer cells is well documented, for example in conditions of oxidative stress (Lucibello et al 2011), or of treatment with various anticancer drugs, the latter often resulting in chemoresistance of these cells (Li et al 2001;Jung et al 2014;Graidist et al 2004;Bommer et al 2017;He et al 2015), which is a frequent problem in cancer chemotherapy. 2.…”

Section: Mechanistic Involvement In Cancer Progressionmentioning

confidence: 99%

The Translational Controlled Tumour Protein TCTP: Biological Functions and Regulation

Bommer

2017

Results and Problems in Cell Differentiation

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The Translational Controlled Tumour Protein TCTP (gene symbol TPT1, also called P21, P23, Q23, fortilin or histamine-releasing factor, HRF) is a highly conserved protein present in essentially all eukaryotic organisms and involved in many fundamental cell biological and disease processes. It was first discovered about 35 years ago, and it took an extended period of time for its multiple functions to be revealed, and even today we do not yet fully understand all the details. Having witnessed most of this history, in this chapter, I give a brief overview and review the current knowledge on the structure, biological functions, disease involvements and cellular regulation of this protein. TCTP is able to interact with a large number of other proteins and is therefore involved in many core cell biological processes, predominantly in the response to cellular stresses, such as oxidative stress, heat shock, genotoxic stress, imbalance of ion metabolism as well as other conditions. Mechanistically, TCTP acts as an anti-apoptotic protein, and it is involved in DNA-damage repair and in cellular autophagy. Thus, broadly speaking, TCTP can be considered a cytoprotective protein. In addition, TCTP facilitates cell division through stabilising the mitotic spindle and cell growth through modulating growth signalling pathways and through its interaction with the proteosynthetic machinery of the cell. Due to its activities, both as an anti-apoptotic protein and in promoting cell growth and division, TCTP is also essential in the early development of both animals and plants. Apart from its involvement in various biological processes at the cellular level, TCTP can also act as an extracellular protein and as such has been involved in modulating whole-body defence processes, namely in the mammalian immune system. Extracellular TCTP, typically in its dimerised form, is able to induce the release of cytokines and other signalling molecules from various types of immune cells. There are also several examples, where TCTP was shown to be involved in antiviral/antibacterial defence in lower animals. In plants, the protein appears to have a protective effect against phytotoxic stresses, such as flooding, draught, too high or low temperature, salt stress or exposure to heavy metals. The finding for the latter stress condition is corroborated by earlier reports that TCTP levels are considerably up-regulated upon exposure of earthworms to high levels of heavy metals. Given the involvement of TCTP in many biological processes aimed at maintaining cellular or whole-body homeostasis, it is not surprising that dysregulation of TCTP levels may promote a range of disease processes, foremost cancer. Indeed a large body of evidence now supports a role of TCTP in at least the most predominant types of human cancers. Typically, this can be ascribed to both the anti-apoptotic activity of the protein and to its function in promoting cell growth and division. However, TCTP also appears to be involved in the later stages of cancer progression, such ...

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“…For example in LNCaP prostate cancer cells, decreased expression of TCTP was associated with reduced cell viability [79]. Similarly, Lucibello et al [48] demonstrated that cell clones with forced TCTP expression, derived from the breast cancer cell line MDA-MB-231, displayed reduced sensitivity to oxidative stress, whereas cells with down-regulated TCTP showed increased sensitivity.…”

Section: • Mechanisms Through Which Tctp Could Promote Cancermentioning

confidence: 95%

“…Gnanasekar et al [47] reported that TCTP of the parasite Brugia malayi functions as an antioxidant protein. More recently, Lucibello et al [48] studied the importance of TCTP in the protection of cancer cells against oxidative stress, and showed that it is an important survival protein likely to be involved in the resistance against anti-cancer therapy. Interestingly, this paper also reports that glucose deprivation resulted in down-regulation of TCTP, followed by cell death.…”

Section: + -Atpasementioning

confidence: 99%

Cellular Function and Regulation of the Translationally Controlled Tumour Protein TCTP

Bommer¹

2012

TOALLJ

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Abstract:The 'translationally controlled tumour protein' TCTP was originally discovered 30 years ago by researchers interested in proteins regulated at the translational level. Cloning and sequencing confirmed the conservation of this protein among all eukaryotic kingdoms, but did not reveal any functional clue, and TCTP was listed in the databases as a 'family' of its own. The functional characterisation of this protein extended over more than a decade, leading to a plethora of individual functions and interactions that have been ascribed to this protein. A major addition to the functional characterisation of TCTP was the identification in 1995 of its histamine releasing factor (HRF) activity in allergic conditions, which for the first time described an extracellular activity for TCTP in human disease. This triggered a host of additional publications aimed at characterising this HRF activity, which are discussed in other articles of this issue. Another milestone in the elucidation of TCTP's function was the demonstration of its anti-apoptotic activity in 2001. Evidence is also accumulating for a role of TCTP in the cell cycle and in early development. This article provides an overview of the main cellular activities of TCTP. The second part will summarise our current knowledge on the mechanisms involved in regulating intracellular TCTP levels.

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TCTP is a critical survival factor that protects cancer cells from oxidative stress-induced cell-death

Cited by 48 publications

References 50 publications

Targeted Efficacy of Dihydroartemisinin for Translationally Controlled Protein Expression in a Lung Cancer Model

Targeted Efficacy of Dihydroartemisinin for Translationally Controlled Protein Expression in a Lung Cancer Model

The Translational Controlled Tumour Protein TCTP: Biological Functions and Regulation

Cellular Function and Regulation of the Translationally Controlled Tumour Protein TCTP

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