TCT-549 CHANGE DAPT: clopidogrel or ticagrelor in acute coronary syndrome patients treated with newer-generation drug-eluting stents

Real-World Safety and Efficacy of Ticagrelor in Patients With St Segment Elevation Myocardial Infarction at Assiut University Heart Hospital

“…The incidence of ischemic stroke (0.8%) were comparable to that of the PLATO 11 , ESTATE 18 , GRAPE registry 19 , CHANGE DAPT 20 and TOPIC studies 21 (1%, 0.4%, 0.7%, and 0.9% and 1.1% respectively). However, the stroke incidence was less than that reported in the PHILO study (2.2%) 17 .…”

“…Cardiovascular mortality incidence (4.2%) in this study was higher as compared to the STEMI PLATO study (3%) 11 , the GRAPE registry (3.1%) 19 , the PHILO study (2.2%) 17 , the TOPIC (1.2%) 21 and CHANGE DAPT studies (2.9%) 20 ; however, it was close to the vascular mortality rate (4.5%) reported in the ESTATE study 18 . This may be attributed to the small sample size of this study and different statistical power.…”

“…The observed myocardial infarction rate (4.2%) in this study was more than that reported in previous studies such as the STEMI patients intended for PPCI subgroup analysis of the PLATO study (3%) 11 , the ESTATE (3.1%) 18 , the CHANGE DAPT (2.2%) 20 and the GRAPE (1.1%) 19 studies. However, the rate was less than reported in the PHILO study (6%) 17 and the unchanged DAPT arm in the TOPIC study (9.3%) 21 .…”

“…Stent thrombosis rate was lower than the STEMI PLATO subgroup analysis 11 ; 3.3%, while the rate was higher as compared to the CHANGE DAPT (0.8%) 20 .…”