TCT-299 Association of Epicardial Adipose Tissue Inflammation as Assessed by FDG PET-CT with Angiographic Coronary Artery Disease

Kaushik, Manu; Degenhardt, Scott; Paknikar, Subhash; Ramachandran, Jyoti; Kandasamy, Vimalkumar Veerappan; Ramachandran, A.; Saurav, Alok; Alla, Venkata; Mohiuddin, Syed M.

doi:10.1016/j.jacc.2014.07.344

Cited by 1 publication

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“…Other types of imaging studies have been undertaken, such as CT (Sarin et al, ; den Dekker et al, ; Harada et al, ; Hung et al, ; Kitagawa et al, ), PET‐CT (Janik et al, ; Bakkum et al, ), MRI (Kim et al, ; Gaborit et al, ; Hua et al, ) and fluoro‐deoxyglucose PET (Kaushik et al, ; Mazurek et al, ). The principal advantage of all these methods is that they are non‐invasive, and there is generally much better resolution than in echocardiographic studies.…”

Section: Approaches To Studying Eatmentioning

confidence: 99%

Investigating interactions between epicardial adipose tissue and cardiac myocytes: what can we learn from different approaches?

Rietdorf

MacQueen

2017

British J Pharmacology

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Heart disease is a major cause of morbidity and mortality throughout the world. Some cardiovascular conditions can be modulated by lifestyle factors such as increased exercise or a healthier diet, but many require surgical or pharmacological interventions for their management. More targeted and less invasive therapies would be beneficial. Recently it has become apparent that epicardial adipose tissue plays an important role in normal and pathological cardiac function, and it is now the focus of considerable research. Epicardial adipose tissue can be studied by imaging of various kinds, and these approaches have yielded much useful information. However at a molecular level it is more difficult to study as it is relatively scarce in animal models and, for practical and ethical reasons, not always available in sufficient quantities from patients. What is needed is a robust model system in which the interactions between epicardial adipocytes and cardiac myocytes can be studied, and physiologically relevant manipulations performed. There are drawbacks to conventional culture methods, not least the difficulty of culturing both cardiac myocytes and adipocytes, each of which has special requirements. We discuss the benefits of a three-dimensional coculture model in which in vivo interactions can be replicated. EAT and cardiac myocytesThis article is protected by copyright. All rights reserved.

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