TCR-dependent sensitization of human γδ T cells to non-myeloid IL-18 in cytomegalovirus and tumor stress surveillance

Guerville, Florent; Daburon, Sophie; Marlin, Romain; Lartigue, Lydia; Loizon, Séverine; Pitard, Vincent; Couzi, Lionel; Moreau, Jean-François; Déchanet‐Merville, Julie; Faustin, Benjamin

doi:10.1080/2162402x.2014.1003011

Cited by 21 publications

(26 citation statements)

References 51 publications

(64 reference statements)

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“…Several studies have suggested that HCMV infection triggers inflammasome activation events including production of mature IL‐1β and IL‐18 . In particular, AIM2 inflammasome regulates immune responses against a broad spectrum of pathogens, including MCMV, however its role in HCMV infection is poorly studied.…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, mature IL‐18, another key product of the activated inflammasome, was detected in serum samples from renal transplant recipients suffering from either primary or latent HCMV infection . A recent report has shown that HCMV infected human umbilical vein endothelial cells (HUVECs) released soluble IL‐18, which enhanced cytotoxicity and IFN‐γ production . Notably, mouse cytomegalovirus (MCMV) is recognized by absent in melanoma 2 (AIM2) .…”

Section: Introductionmentioning

confidence: 99%

“…15 A recent report has shown that HCMV infected human umbilical vein endothelial cells (HUVECs) released soluble IL-18, which enhanced cytotoxicity and IFN-γ production. 16 Notably, mouse cytomegalovirus (MCMV) is recognized by absent in melanoma 2 (AIM2). 17 The AIM2 inflammasome has been described as a pattern recognition receptor (PRRs) that plays an important role in regulating immune responses to viral and bacterial pathogens.…”

Section: Introductionmentioning

confidence: 99%

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Human cytomegalovirus triggers the assembly of AIM2 inflammasome in THP‐1‐derived macrophages

Huang

Liu

Ma³

et al. 2017

Journal of Medical Virology

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Absent in melanoma 2 (AIM2) inflammasome is a multiprotein complex which plays a pivotal role in the host immune response to multiple pathogens. The role of AIM2 in human cytomegalovirus (HCMV) infection is poorly studied. Thus, using a small inference RNA (siRNA) approach and THP-1 derived macrophage cells infected with HCMV AD169 strain, we investigated the impact of HCMV infection on AIM2-mediated molecular events. Compared to wild-type cells, AIM2-defiecient macrophages showed a limited ability to activate caspase-1, process IL-1β, and induce cell death. In addition, AIM2-defiecient cells were unable to efficiently control HCMV infection, as the transcription of virus DNA polymerase gene UL54 and major tegument protein gene UL83 were higher compared to wild-type cells. In conclusion, HCMV infection induces an AIM2 inflammasome response, which negatively influences viral life cycle.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Human cytomegalovirus triggers the assembly of AIM2 inflammasome in THP‐1‐derived macrophages

Huang

Liu

Ma³

et al. 2017

Journal of Medical Virology

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“…[102][103][104][105] Expansion of Vd2 À T cells is associated with viral clearance both in immunosuppressed 102,106,107 and in healthy populations. 110 During secondary infection, cells proliferate and resolve infection Table 1. 110 During secondary infection, cells proliferate and resolve infection Table 1.…”

Section: Viral Infectionsmentioning

confidence: 99%

Emerging role of γδ T cells in vaccine‐mediated protection from infectious diseases

2019

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γδ T cells are fascinating cells that bridge the innate and adaptive immune systems. They have long been known to proliferate rapidly following infection; however, the identity of the specific γδ T cell subsets proliferating and the role of this expansion in protection from disease have only been explored more recently. Several recent studies have investigated γδ T‐cell responses to vaccines targeting infections such as Mycobacterium, Plasmodium and influenza, and studies in animal models have provided further insight into the association of these responses with improved clinical outcomes. In this review, we examine the evidence for a role for γδ T cells in vaccine‐induced protection against various bacterial, protozoan and viral infections. We further discuss results suggesting potential mechanisms for protection, including cytokine‐mediated direct and indirect killing of infected cells, and highlight remaining open questions in the field. Finally, building on current efforts to integrate strategies targeting γδ T cells into immunotherapies for cancer, we discuss potential approaches to improve vaccines for infectious diseases by inducing γδ T‐cell activation and cytotoxicity.

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“…2 Upon TCR ligation, some subsets of gd T cells mediate cytotoxic effects through perforin 1 (PRF1) and granzyme B (GRZB), and support T H 1 helper responses by secreting interferon gamma (IFNg) and tumor necrosis factor (TNF). 1,3 In specific preclinical models, interleukin 17 (IL-17)-producing gd T cells also contribute to tumor-targeting immune responses elicited by chemotherapy or specific radiotherapeutic regimens. [4][5][6] These considerations have fostered the development of multiple strategies to promote tumor recognition and elimination by gd T cells, 7 including bispecific antibodies simultaneously targeting one Vg chain and one tumor-associated antigen.…”

Section: Cd8mentioning

confidence: 99%

Immunosuppressive γδ T cells foster pancreatic carcinogenesis

2016

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TCR-dependent sensitization of human γδ T cells to non-myeloid IL-18 in cytomegalovirus and tumor stress surveillance

Cited by 21 publications

References 51 publications

Human cytomegalovirus triggers the assembly of AIM2 inflammasome in THP‐1‐derived macrophages

Human cytomegalovirus triggers the assembly of AIM2 inflammasome in THP‐1‐derived macrophages

Emerging role of γδ T cells in vaccine‐mediated protection from infectious diseases

Immunosuppressive γδ T cells foster pancreatic carcinogenesis

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