TCF21 is related to testis growth and development in broiler chickens

Zhang, Hui; Wei, Na; Zhang, Hongli; Wang, Ning; Du, Zhiqiang; Wang, Shouzhi; Wang, Zhipeng; Zhang, Zhiwu; Li, Hui

doi:10.1186/s12711-017-0299-0

Cited by 15 publications

(20 citation statements)

References 76 publications

(37 reference statements)

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“…The birds from lean and fat chicken lines used in the current study had significantly different amounts of abdominal fat content and significantly different testis weight, which was an ideal population to study the genetic architecture of abdominal fat deposition and testis growth and development [ 19 ]. The birds used in the current study were 7-week-old, therefore, the results of the current study could reflect early testis development.…”

Section: Discussionmentioning

confidence: 99%

“…Roosters with small testes often have poor fertility [ 25 ]. There have been previously reported studies on the genetics of testis development in chicken [ 19 ]. However, most of the previous studies focused on additive genetic effects, while, epistatic effects were ignored.…”

Section: Discussionmentioning

confidence: 99%

“…For testis weight, a total of 421 pairs of SNP-SNP epistatic interactions were detected. These pairs of SNPs comprised 211 single SNPs, and none of these individual SNPs were identified in our previous GWAS analysis for testis weight [ 19 ]. A similar phenomenon was also detected by Wu et al for psoriasis in human [ 26 ].…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, it is proposed that miR-142-5p and TCF12 might work together to regulate the reproductive function of male broilers. Furthermore, TCF12 was a partner of TCF21 , which was detected as an important gene for testis growth and development in our previous GWAS result [ 19 ].…”

Section: Discussionmentioning

confidence: 99%

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Identification of genome-wide SNP-SNP interactions associated with important traits in chicken

Zhang

Yang

et al. 2017

BMC Genomics

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BackgroundIn addition to additive genetic effects, epistatic interactions can play key roles in the control of phenotypic variation of traits of interest. In the current study, 475 male birds from lean and fat chicken lines were utilized as a resource population to detect significant epistatic effects associated with growth and carcass traits.ResultsA total of 421 significant epistatic effects were associated with testis weight (TeW), from which 11 sub-networks (Sub-network1 to Sub-network11) were constructed. In Sub-network1, which was the biggest network, there was an interaction between GGA21 and GGAZ. Three genes on GGA21 (SDHB, PARK7 and VAMP3) and nine genes (AGTPBP1, CAMK4, CDC14B, FANCC, FBP1, GNAQ, PTCH1, ROR2 and STARD4) on GGAZ that might be potentially important candidate genes for testis growth and development were detected based on the annotated gene function. In Sub-network2, there was a SNP on GGA19 that interacted with 8 SNPs located on GGA10. The SNP (Gga_rs15834332) on GGA19 was located between C-C motif chemokine ligand 5 (CCL5) and MIR142. There were 32 Refgenes on GGA10, including TCF12 which is predicted to be a target gene of miR-142-5p. We hypothesize that miR-142-5p and TCF12 may interact with one another to regulate testis growth and development. Two genes (CDH12 and WNT8A) in the same cadherin signaling pathway were implicated as potentially important genes in the control of metatarsus circumference (MeC). There were no significant epistatic effects identified for the other carcass and growth traits, e.g. heart weight (HW), liver weight (LW), spleen weight (SW), muscular and glandular stomach weight (MGSW), carcass weight (CW), body weight (BW1, BW3, BW5, BW7), chest width (ChWi), metatarsus length (MeL).ConclusionsThe results of the current study are helpful to better understand the genetic basis of carcass and growth traits, especially for testis growth and development in broilers.Electronic supplementary materialThe online version of this article (10.1186/s12864-017-4252-y) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Identification of genome-wide SNP-SNP interactions associated with important traits in chicken

Zhang

Yang

et al. 2017

BMC Genomics

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“…There is also evidence suggesting the presence of a substantial genetic component (Chubb 1992; Soulsbury 2010; Zhang et al 2017). For example, Le Roy et al (2001) performed a quantitative genetic analysis across thirteen inbred strains of laboratory mice and found that heritability accounted for 82.3% of the total variance in testis weight.…”

Section: Introductionmentioning

confidence: 99%

Genome-wide association for testis weight in the diversity outbred mouse population

et al. 2018

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Testis weight is a genetically mediated trait associated with reproductive efficiency across numerous species. We sought to evaluate the genetically diverse, highly recombinant Diversity Outbred (DO) mouse population as a tool to identify and map quantitative trait loci (QTLs) associated with testis weight. Testis weights were recorded for 502 male DO mice and the mice were genotyped on the GIGAMuga array at ~ 143,000 SNPs. We performed a genome-wide association analysis and identified one significant and two suggestive QTLs associated with testis weight. Using bioinformatic approaches, we developed a list of candidate genes and identified those with known roles in testicular size and development. Candidates of particular interest include the RNA demethylase gene Alkbh5, the cyclin-dependent kinase inhibitor gene Cdkn2c, the dynein axonemal heavy chain gene Dnah11, the phospholipase D gene Pld6, the trans-acting transcription factor gene Sp4, and the spermatogenesis-associated gene Spata6, each of which has a human ortholog. Our results demonstrate the utility of DO mice in high-resolution genetic mapping of complex traits, enabling us to identify developmentally important genes in adult mice. Understanding how genetic variation in these genes influence testis weight could aid in the understanding of mechanisms of mammalian reproductive function.

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