Tcf15 Primes Pluripotent Cells for Differentiation

Davies, Owen R.; Lin, Chia–Yi; Radzisheuskaya, Aliaksandra; Zhou, Xiaohu; Taube, Jessica; Blin, Guillaume; Waterhouse, Anna; Smith, Andrew J.H.; Lowell, Sally

doi:10.1016/j.celrep.2013.01.017

Cited by 57 publications

(76 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furthermore, somite formation is disrupted in Tcf15-deficient mice (59). TCF15 primes pluripotent cells for entry to the somatic lineage, and forced expression of TCF15 in ES cells suppresses endodermal differentiation (60). Gbx2 is a homeobox gene and downstream target of LIF/STAT3 in ES cells (61).…”

Section: Discussionmentioning

confidence: 99%

ETS-related Transcription Factors ETV4 and ETV5 Are Involved in Proliferation and Induction of Differentiation-associated Genes in Embryonic Stem (ES) Cells

Akagi

Kuure

Uranishi

et al. 2015

Journal of Biological Chemistry

View full text Add to dashboard Cite

Background: Characteristics of ES cells are controlled by gene regulatory networks, and ETV4 and -5 participate in the network. Results: Proliferation, induction of ectodermal marker genes, and expression of stem cell-related genes were impaired in Etv4/5 double KO ES cells. Conclusion: ETV4 and -5 crucially define properties of ES cells. Significance: Gene regulatory networks are dysregulated in the double KO ES cells.

show abstract

Section: Discussionmentioning

confidence: 99%

ETS-related Transcription Factors ETV4 and ETV5 Are Involved in Proliferation and Induction of Differentiation-associated Genes in Embryonic Stem (ES) Cells

Akagi

Kuure

Uranishi

et al. 2015

Journal of Biological Chemistry

View full text Add to dashboard Cite

show abstract

“…TCF15 primes pluripotent cells for differentiation [32]. During dermomyotome formation in Xenopus laevis, TCF15 directly activates the expression of MEOX2 [31].…”

Section: Discussionmentioning

confidence: 99%

“…Recruitment for the FLEMENGHO study started in 1985 [8,9]. From August 1985 to November 1990, a random sample of the households living in a geographically defined area of Northern Belgium was investigated with the goal to recruit an equal number of participants in each of six strata by sex and age (20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37)(38)(39)(40)(41)(42)(43)(44)(45)(46)(47)(48)(49)(50)(51)(52)(53)(54)(55)(56)(57)(58)(59), and ≥60 years). All household members aged 20 years or older were invited, if the quota of their sex-age group had not yet been met.…”

Section: Study Populationmentioning

confidence: 99%

P4.2 Coronary Risk in Relation to Genetic Variation in Meox2 and Tcf15 in a Flemish Population

Yang

Petit

Thijs

et al. 2015

ARTRES

View full text Add to dashboard Cite

Background: In mice MEOX2/TCF15 heterodimers are highly expressed in heart endothelial cells and are involved in the transcriptional regulation of lipid transport. In a general population, we investigated whether genetic variation in these genes predicted coronary heart disease (CHD). Results: In 2027 participants randomly recruited from a Flemish population (51.0 % women; mean age 43.6 years), we genotyped six SNPs in MEOX2 and four in TCF15. Over 15.2 years (median), CHD, myocardial infarction, coronary revascularisation and ischaemic cardiomyopathy occurred in 106, 53, 78 and 22 participants. For SNPs, we contrasted CHD risk in minor-allele heterozygotes and homozygotes (variant) vs. major-allele homozygotes (reference) and for haplotypes carriers (variant) vs. non-carriers. In multivariable-adjusted analyses with correction for multiple testing, CHD risk was associated with MEOX2 SNPs (P ≤ 0.049), but not with TCF15 SNPs (P ≥ 0.29). The MEOX2 GTCCGC haplotype (frequency 16.5 %) was associated with the sex-and age-standardised CHD incidence (5.26 vs. 3.03 events per 1000 person-years; P = 0.036); the multivariable-adjusted hazard ratio [HR] of CHD was 1.78 (95 % confidence interval, 1.25-2.56; P = 0.0054). For myocardial infarction, coronary revascularisation, and ischaemic cardiomyopathy, the corresponding HRs were 1.96 (1.16-3.31), 1.87 (1.20-2.91) and 3.16 (1.41-7.09), respectively. The MEOX2 GTCCGC haplotype significantly improved the prediction of CHD over and beyond traditional risk factors and was associated with similar population-attributable risk as smoking (18.7 % vs. 16.2 %). Conclusions: Genetic variation in MEOX2, but not TCF15, is a strong predictor of CHD. Further experimental studies should elucidate the underlying molecular mechanisms.

show abstract

“…Though its expression is detected postimplantation at approximately 6.5 dpc, Nanog expression is downregulated in the Epi during implantation under direct repression by Tcf15 [124,125]. Nanog plays a central role in the regulation of naive pluripotency, directly interacting with genes such as Esrrb, Sall4 and Tbx3 [126,127].…”

Section: (B) Regulatory Network Governing the First Cell Fate Choicesmentioning

confidence: 99%

From blastocyst to gastrula: gene regulatory networks of embryonic stem cells and early mouse embryogenesis

Parfitt

Shen

2014

Phil. Trans. R. Soc. B

View full text Add to dashboard Cite

To date, many regulatory genes and signalling events coordinating mammalian development from blastocyst to gastrulation stages have been identified by mutational analyses and reverse-genetic approaches, typically on a geneby-gene basis. More recent studies have applied bioinformatic approaches to generate regulatory network models of gene interactions on a genome-wide scale. Such models have provided insights into the gene networks regulating pluripotency in embryonic and epiblast stem cells, as well as cell-lineage determination in vivo. Here, we review how regulatory networks constructed for different stem cell types relate to corresponding networks in vivo and provide insights into understanding the molecular regulation of the blastocyst-gastrula transition.

show abstract

Tcf15 Primes Pluripotent Cells for Differentiation

Cited by 57 publications

References 49 publications

ETS-related Transcription Factors ETV4 and ETV5 Are Involved in Proliferation and Induction of Differentiation-associated Genes in Embryonic Stem (ES) Cells

ETS-related Transcription Factors ETV4 and ETV5 Are Involved in Proliferation and Induction of Differentiation-associated Genes in Embryonic Stem (ES) Cells

P4.2 Coronary Risk in Relation to Genetic Variation in Meox2 and Tcf15 in a Flemish Population

From blastocyst to gastrula: gene regulatory networks of embryonic stem cells and early mouse embryogenesis

Contact Info

Product

Resources

About