TCF12 Activates the TGF-β/smad2/3 Signaling Pathway to Promote the Progression of Osteoarthritis

Advances in osteoarthritis research: From diagnosis, treatment to mechanism studies

“…Senescent chondrocytes usually exhibited impaired regenerative capacity and imbalanced metabolism of extracellular matrix proteins. Recently, Zhang et al reported a new chondrocyte senescence regulator, transcription factor 12 (TCF12) [ 4 ]. In damaged areas of OA articular cartilage and IL-1β-treated chondrocytes, the TCF12 expression was significantly upregulated.…”