TCF-1 Controls ILC2 and NKp46+RORγt+ Innate Lymphocyte Differentiation and Protection in Intestinal Inflammation

Mielke, Lisa A.; Groom, Joanna R; Rankin, Lucille C.; Seillet, Cyril; Masson, Frédérick; Putoczki, Tracy L.; Belz, Gabrielle T.

doi:10.4049/jimmunol.1301228

Cited by 124 publications

(113 citation statements)

References 51 publications

Supporting

Mentioning

109

Contrasting

Order By: Relevance

“…1). Progressive commitment to the ILC lineage is also dependent, to varying degrees, on a multitude of transcription factors including GATA‐3, TOX, TCF‐1 and NFIL316, 17, 18, 19, 20, 21 (and reviewed in detail in references 10 and 22). …”

Section: Group 3 Innate Lymphoid Cell Developmentmentioning

confidence: 99%

Functional and phenotypic heterogeneity of group 3 innate lymphoid cells

2017

View full text Add to dashboard Cite

SummaryGroup 3 innate lymphoid cells (ILC3), defined by expression of the transcription factor retinoid‐related orphan receptor γt, play key roles in the regulation of inflammation and immunity in the gastrointestinal tract and associated lymphoid tissues. ILC3 consist largely of two major subsets, NCR + ILC3 and LTi‐like ILC3, but also demonstrate significant plasticity and heterogeneity. Recent advances have begun to dissect the relationship between ILC3 subsets and to define distinct functional states within the intestinal tissue microenvironment. In this review we discuss the ever‐expanding roles of ILC3 in the context of intestinal homeostasis, infection and inflammation – with a focus on comparing and contrasting the relative contributions of ILC3 subsets.

show abstract

Section: Group 3 Innate Lymphoid Cell Developmentmentioning

confidence: 99%

Functional and phenotypic heterogeneity of group 3 innate lymphoid cells

2017

View full text Add to dashboard Cite

show abstract

“…For example, GATA-binding protein 3 (GATA3) and T cell factor 1 (TCF1) have both been identified as important for regulating ILC2 development (23,24). However, both of these factors have been demonstrated previously to be essential for normal T-cell development, and further investigation has revealed that GATA3 and TCF-1 are required for the generation of a progenitor downstream of the common lymphoid progenitor (CLPs) but upstream of the Id2 1 ILC precursor and are required for multiple ILC subsets (25,26) (Figure 1). …”

Section: Ilc Precursorsmentioning

confidence: 99%

Type-2 Innate Lymphoid Cells in Asthma and Allergy

McKenzie

2014

Annals ATS

110

View full text Add to dashboard Cite

Type-2 innate lymphoid cells (ILC2) belong to an expanding family of innate lymphocytes that provide a potent source of immune effector cytokines at the initiation of immune responses. ILC2 arise, under the control of the transcription factors RORa and GATA3, from lymphoid progenitors in the bone marrow, to secrete type-2 cytokines including IL-5 and IL-13. Using experimental models, ILC2 have been implicated in allergic diseases, such as asthma and atopic dermatitis, but also in metabolic homeostasis. Furthermore, recent reports have indicated that ILC2 not only play roles at the initiation of type-2 immunity but can also contribute to chronic pathology, such as fibrosis, and can impact on the priming of the adaptive T-cell response. The identification of ILC2 in patients with allergic dermatitis and allergic rhinitis indicates that these cells may represent new therapeutic targets.Keywords: type-2 immunity; type-2 innate lymphoid cells; innate immunity; cytokines However, a recent major paradigm shift has added another layer of complexity to immunoregulation by cytokines with the discovery of innate lymphoid cells (ILCs) (2). ILCs produce many Th cell-associated cytokines but do not express cell surface markers associated with other immune cell lineages (lineage-negative [Lin 2 ]) and do not express a T-cell receptor. The ILC family now includes ILC1 (predominantly IFN-g-expressing cells), ILC2 (predominantly IL-5-and IL-13-expressing cells), and ILC3 (predominantly IL-22-and IL-17-expressing cells) (3-6). Due to their recent discovery, our knowledge of these cells is still rather rudimentary, but major roles are emerging for ILCs in protective immunity against parasitic helminths (ILC2) (7-9) and bacteria (ILC1 and ILC3) (10-12), and in autoimmune disorders (ILC1 and ILC3) (13), allergic disease (ILC2) (14-16), and obesity (17)(18)(19).Recent comprehensive reviews have described the identification and phenotypic characterization of 20). This review focuses on the most recent advances in our understanding of the factors that regulate ILC2 development and how these cells contribute to allergy and lung inflammation. ILC2ILC2 are found in the blood, spleen, intestine, liver, lung, fat-associated lymphoid clusters, and lymph nodes of mice (7-9). They are Lin 2 (CD3CD4CD8CD19CD11bCD11cFceR1 NK1.1Gr1 2 ) CD45 1 CD127

show abstract

“…17 Lymphocytes were isolated from colon lamina propria as previously described. 26 Liver-infiltrating lymphocytes were isolated by centrifugation liver cell suspension on a 33.75% isotonic Percoll (GE Healthcare Biosciences) density gradient for 12 minutes at 693g at room temperature.…”

Section: T-cell Isolationmentioning

confidence: 99%