TCB-2, a 5-hydroxytryptamine 2A receptor agonist, disrupts prepulse inhibition in the ventral pallidum and nucleus accumbens

Ou, Huaxing; Tang, Jiaxin; Guo, Guanlong; Shi, Meng-Wen; Yang, Chung‐Yi; Chen, Weihai

doi:10.1016/j.bbr.2022.114127

Cited by 3 publications

(2 citation statements)

References 43 publications

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“…Therefore, the implementation of dorsal striatum and its dopaminergic modulation is a possible extension of the present computational model. Other neuromodulators such as serotonin and adrenaline are also involved in the PPI [5,77,78]. Interestingly, the systemic administration or injection into NAc of cannabidiol attenuated the deficit caused by amphetamine in mice [79].…”

Section: Discussionmentioning

confidence: 99%

A Computational Model for the Simulation of Prepulse Inhibition and Its Modulation by Cortical and Subcortical Units

Bezerra,

Roque,

Salum

2024

Brain Sciences

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The sensorimotor gating is a nervous system function that modulates the acoustic startle response (ASR). Prepulse inhibition (PPI) phenomenon is an operational measure of sensorimotor gating, defined as the reduction of ASR when a high intensity sound (pulse) is preceded in milliseconds by a weaker stimulus (prepulse). Brainstem nuclei are associated with the mediation of ASR and PPI, whereas cortical and subcortical regions are associated with their modulation. However, it is still unclear how the modulatory units can influence PPI. In the present work, we developed a computational model of a neural circuit involved in the mediation (brainstem units) and modulation (cortical and subcortical units) of ASR and PPI. The activities of all units were modeled by the leaky-integrator formalism for neural population. The model reproduces basic features of PPI observed in experiments, such as the effects of changes in interstimulus interval, prepulse intensity, and habituation of ASR. The simulation of GABAergic and dopaminergic drugs impaired PPI by their effects over subcortical units activity. The results show that subcortical units constitute a central hub for PPI modulation. The presented computational model offers a valuable tool to investigate the neurobiology associated with disorder-related impairments in PPI.

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Section: Discussionmentioning

confidence: 99%

A Computational Model for the Simulation of Prepulse Inhibition and Its Modulation by Cortical and Subcortical Units

Bezerra,

Roque,

Salum

2024

Brain Sciences

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“…Psychedelics interfere with preattentive sensorimotor gating (Halberstadt and Geyer, 2018), a filter process conceptually reminiscent of the ego's stimulus barrier function (Bellak et al, 1973). The psychedelic-induced filter deficit appears to have roots in the locus coeruleus (Rasmussen and Aghajanian, 1986), the pallidum (Sipes and Geyer, 1997;Ou et al, 2023), and/or in a thalamic filter deficit (Geyer and Vollenweider, 2008;Preller et al, 2019). If the brain areas underlying the psychedelic stimulus barrier disruption are so widespread already, a more globally induced ego disintegration is not likely to emerge from interference with a singular brain hub either but rather from network activity or the underlying (de-)synchronization processes.…”

Section: Neurobiology Of Ego Alterations -A Matter Of Network (De-)sy...mentioning

confidence: 99%

The ego in psychedelic drug action – ego defenses, ego boundaries, and the therapeutic role of regression

Buchborn,

Kettner,

Kärtner

et al. 2023

Front. Neurosci.

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The ego is one of the most central psychological constructs in psychedelic research and a key factor in psychotherapy, including psychedelic-assisted forms of psychotherapy. Despite its centrality, the ego-construct remains ambiguous in the psychedelic literature. Therefore, we here review the theoretical background of the ego-construct with focus on its psychodynamic conceptualization. We discuss major functions of the ego including ego boundaries, defenses, and synthesis, and evaluate the role of the ego in psychedelic drug action. According to the psycholytic paradigm, psychedelics are capable of inducing regressed states of the ego that are less protected by the ego’s usual defensive apparatus. In such states, core early life conflicts may emerge that have led to maladaptive ego patterns. We use the psychodynamic term character in this paper as a potential site of change and rearrangement; character being the chronic and habitual patterns the ego utilizes to adapt to the everyday challenges of life, including a preferred set of defenses. We argue that in order for psychedelic-assisted therapy to successfully induce lasting changes to the ego’s habitual patterns, it must psycholytically permeate the characterological core of the habits. The primary working principle of psycholytic therapy therefore is not the state of transient ego regression alone, but rather the regressively favored emotional integration of those early life events that have shaped the foundation, development, and/or rigidification of a person’s character – including his or her defense apparatus. Aiming for increased flexibility of habitual ego patterns, the psycholytic approach is generally compatible with other forms of psychedelic-assisted therapy, such as third wave cognitive behavioral approaches.

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Effects of psilocybin, the 5-HT2A receptor agonist TCB-2, and the 5-HT2A receptor antagonist M100907 on visual attention in male mice in the continuous performance test

Rahbarnia,

Li,

Fletcher

2023

Psychopharmacology

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TCB-2, a 5-hydroxytryptamine 2A receptor agonist, disrupts prepulse inhibition in the ventral pallidum and nucleus accumbens

Cited by 3 publications

References 43 publications

A Computational Model for the Simulation of Prepulse Inhibition and Its Modulation by Cortical and Subcortical Units

A Computational Model for the Simulation of Prepulse Inhibition and Its Modulation by Cortical and Subcortical Units

The ego in psychedelic drug action – ego defenses, ego boundaries, and the therapeutic role of regression

Effects of psilocybin, the 5-HT2A receptor agonist TCB-2, and the 5-HT2A receptor antagonist M100907 on visual attention in male mice in the continuous performance test

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