Tc-99m(V) DMSA Imaging

Increased Breast Density Correlates with the Proliferation-Seeking Radiotracer99mTc(V)-DMSA Uptake in Florid Epithelial Hyperplasia and in Mixed Ductal Carcinoma in Situ with Invasive Ductal Carcinoma but Not in Pure Invasive Ductal Carcinoma or in Mild Epithelial Hyperplasia

“…[6][7][8][9][10][11][12][13][14] Technetium 99m pentavalent dimercaptosuccinic acid ( 99m Tc(V)-DMSA) is a well-known cell proliferationseeking radiotracer with affinity for neuroendocrine and soft tissue tumors, such as medullary thyroid carcinoma and lung, breast, brain, and metastatic bone lesions. [15][16][17][18][19][20][21][22][23][24][25][26][27] Based on in vivo scintigraphic studies, we initially suggested that its cellular uptake mechanism is closely related to cellular proliferation, as expressed by the Ki-67 immunohistologic index [28][29][30] and at the same time independent from estrogen receptor (ER) status. 23,24 Denoyer and colleagues elucidated the exact mechanisms: the tracer reflects phosphate ion (Pi) transport and metabolism, entering cancer cells specifically via the type III Na/Pi cotransporter, this uptake being driven by the cellular levels of phosphorylated (ie, activated) focal adhesion kinase (FAK), a keystone of accelerated proliferation.…”

“…[15][16][17][18][19][20][21][22][23][24][25][26][27] Based on in vivo scintigraphic studies, we initially suggested that its cellular uptake mechanism is closely related to cellular proliferation, as expressed by the Ki-67 immunohistologic index [28][29][30] and at the same time independent from estrogen receptor (ER) status. 23,24 Denoyer and colleagues elucidated the exact mechanisms: the tracer reflects phosphate ion (Pi) transport and metabolism, entering cancer cells specifically via the type III Na/Pi cotransporter, this uptake being driven by the cellular levels of phosphorylated (ie, activated) focal adhesion kinase (FAK), a keystone of accelerated proliferation. 26,27 Recent in vivo and in vitro studies have demonstrated its potential to depict increased cellular proliferation not only in invasive carcinoma but also in epithelial hyperplasia of the usual type and in preinvasive mammary lesions (ie, DCIS), independently of the presence of estrogen and progesterone receptors.…”

Nanomaterial Sorbents for the Preparation of 188W/188Re Generator and 188Re Radiopharmaceutical Development

“…Simultaneously the activity per mL can also be increased by using smaller bed size for the column and lower volume of eluent. Tc(V)DMSA is a widely used radiopharmaceutical for diagnostic imaging of medullary carcinoma of thyroid [9][10][11], head and neck tumors, [12,13], soft tissue tumors and metastatic bone lesions and osseous metastasis from breast cancer [14][15][16] Re(V)DMSA and its biological evaluation in Wistar rats [21]. They observed significant uptake of the radiotracer in kidneys, which limited wide spread application of this therapeutic agent in the clinic.…”

Kidney uptake of 186/188Re(V)‐DMSA is significantly reduced when the reducing agent is changed from stannous ion to metabisulfite

“…[6][7][8] Re(V)-DMSA for clinical studies is performed using stannous chloride as the reducing agent. 11,[13][14][15][16] Both the complexes are similar in their tumor-targeting behavior but differ in localization in kidney.…”