Tc-99m–Labeled RBC Scintigraphy and Splenic Hemangioma

Wijaya, Johan; Kapoor, Rony; Roach, Paul

doi:10.1097/00003072-200112000-00006

Cited by 11 publications

(4 citation statements)

References 5 publications

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“…However, as significant siderosis is seen in less than 50% of LCA cases [ 1 ], lesions tend to be hyperintense on the T2 weighted images, as was the case in our patient (Figure 3 ) [ 26 ]. Nuclear medicine studies with Tc-99m labelled RBC scintigraphy can be useful to differentiate splenic lesions from splenic haemangiomas [ 27 , 28 ]. However, the radiologic features of LCA are rarely diagnostic since many other splenic neoplasms such as haemartomas, haemangiomas, lymphomas, metastatic disease and infectious processes exhibit similar imaging characteristics [ 29 ].…”

Section: Discussionmentioning

confidence: 99%

Incidental littoral cell angioma of the spleen

et al. 2008

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Section: Discussionmentioning

confidence: 99%

Incidental littoral cell angioma of the spleen

et al. 2008

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“…Autologous [ 99m Tc]‐labeled erythrocytes have been used to characterize liver hemangiomas or for the differential diagnosis of orbital cavernous hemangiomas . Additionally, this methodology has been used to identify hemangiomatous lesions in other localizations such as vertebra , spleen and cavernous sinus . Other studies have demonstrated the value of this method for the diagnosis and localization of acute or recurrent gastrointestinal bleedings .…”

Section: Introductionmentioning

confidence: 99%

Erythrocytes labeled with [¹⁸F]SFB as an alternative to radioactive CO for quantification of blood volume with PET

Herance

Gispert²,

Abad

et al. 2013

Contrast Media & Molecular

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Inhaled radioactive CO is currently the tracer of choice for blood volume quantification by positron emission tomography (PET). This measurement is of great interest for several clinical and research applications. However, owing to the short half-life of the radiolabeled CO, it can only be used in centers equipped with a cyclotron. In the present work, we propose an alternative method to label the red blood cells with [(18) F] in order to obtain blood volume measurements by PET. The use of the radioactive synthon [(18) F] N-succinimidyl 4-[(18) F]fluorobenzoate ([(18) F]SFB) was evaluated for erythrocyte labeling and PET blood volume imaging. The images provided by [(18) F]SFB labeled erythrocytes were compared with those obtained with inhaled [(11) C]CO. Blood volumes obtained with [(18) F]SFB labeled erythrocytes were similar to those obtained with [(11) C]CO in all of the evaluated organs with the exception of spleen, which presented lower uptake with this method. Since the [(18) F]-SFB binds irreversibly to red blood cells, in vivo stability of the radiolabel was higher compared with the [(11) C]CO method. Additionally, owing to the longer half-life and the shorter positron range of [(18) F], the image quality was also higher with the [(18) F]SFB radiolabeled erythrocytes. The labeling of red blood with [(18) F]SFB represents an advantageous alternative to radioactive CO for blood volume measurement by PET and cardiovascular isotopic imaging.

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“…A case report has shown technetium (Tc-99m)-labeled red blood cell scintigraphy with SPECT can be utilized for confi rming presence of splenic hemangiomas [ 15 ]. By utilizing early and delayed planar and SPECT images, one can evaluate for focal blood pooling on delayed imaging, as has been shown with hepatic hemangiomas [ 16 ].…”

Section: Hemangiomasmentioning

confidence: 99%